eprintid: 20235
rev_number: 12
eprint_status: archive
userid: 1589
dir: disk0/00/02/02/35
datestamp: 2016-03-02 07:33:00
lastmod: 2021-06-15 20:45:37
status_changed: 2016-03-02 07:33:00
type: article
metadata_visibility: show
creators_name: Askoxylakis, Vasileios
creators_name: Hegenbarth, Pia
creators_name: Timke, Carmen
creators_name: Saleh-Ebrahimi, Ladan
creators_name: Debus, Jürgen
creators_name: Röder, Falk
creators_name: Huber, Peter E.
title: Intensity modulated radiation therapy (IMRT) for sinonasal tumors: a single center long-term clinical analysis
subjects: ddc-610
divisions: i-850300
divisions: i-911400
abstract: Background: Radiotherapy has a central role in the treatment of sinonasal malignancies, either as postoperative or as primary therapy. To study the efficacy and safety of intensity modulated radiotherapy (IMRT) for sinonasal tumors a single center retrospective evaluation focusing on survival and therapy related toxicity was performed.   Methods: One hundred twenty two patients with primary (n = 82) or recurrent (n = 40) malignant sinonasal tumors were treated with intensity modulated radiotherapy between 1999 and 2009 at the University Clinic of Heidelberg and the German Cancer Research Center and retrospectively analyzed. Most patients had adenoid cystic carcinomas (n = 47) or squamous cell carcinoma (n = 26). 99 patients received postoperative radiotherapy. The median total dose was 64 Gy in conventional fractionation (1.8–2 Gy). Overall survival (OS), progression free survival (PFS) and local recurrence free survival (LRFS) rates were calculated using the Kaplan-Meier method. The log-rank test and Fishers Exact test were applied for univariate analysis, Cox-regression was used for multivariate analysis.   Results: Median follow up was 36 months. 1-, 3- and 5-year estimated overall survival rates were 90, 70 and 54 % respectively. Median progression free survival and local recurrence free survival was 45 and 63 months respectively. Progression free survival and local recurrence free survival at 1, 3 and 5 years were 76, 57 and 47, and 79, 60 and 51 % respectively. 19 patients (15.5 %) were diagnosed with distant metastases. Univariate analysis revealed significantly improved OS and LRFS for treatment of tumors after primary diagnosis, first series of irradiation and radiation dose ≥60 Gy. Multivariate analysis revealed only treatment in primary situation as an independent prognostic factor for OS and LRFS. Acute CTC grade III mucositis was seen in 5 patients (4.1 %) and CTC grade II dysgeusia in 19 patients (15.6 %). Dysgeusia, dysosmia and ocular toxicity were the most common late adverse events.   Conclusions: Our data support the results of previous studies and indicate that intensity modulated radiation therapy (IMRT) represents an effective and safe treatment approach for patients with sinonasal carcinomas.
date: 2016
publisher: BioMed Central
id_scheme: DOI
ppn_swb: 1655326260
own_urn: urn:nbn:de:bsz:16-heidok-202355
language: eng
bibsort: ASKOXYLAKIINTENSITYM2016
full_text_status: public
publication: Radiation Oncology
volume: 11
number: 17
place_of_pub: London
pagerange: 1-9
issn: 1748-717X
citation:   Askoxylakis, Vasileios ; Hegenbarth, Pia ; Timke, Carmen ; Saleh-Ebrahimi, Ladan ; Debus, Jürgen ; Röder, Falk ; Huber, Peter E.  (2016) Intensity modulated radiation therapy (IMRT) for sinonasal tumors: a single center long-term clinical analysis.  Radiation Oncology, 11 (17).  pp. 1-9.  ISSN 1748-717X     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/20235/1/13014_2016_Article_595.pdf