<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2"^^ . "Background: BRCA1 and, more commonly, BRCA2 mutations are associated with increased risk of male breast cancer (MBC). However, only a paucity of data exists on the pathology of breast cancers (BCs) in men with BRCA1/2 mutations. Using the largest available dataset, we determined whether MBCs arising in BRCA1/2 mutation carriers display specific pathologic features and whether these features differ from those of BRCA1/2 female BCs (FBCs). Methods: We characterised the pathologic features of 419 BRCA1/2 MBCs and, using logistic regression analysis, contrasted those with data from 9675 BRCA1/2 FBCs and with population-based data from 6351 MBCs in the Surveillance, Epidemiology, and End Results (SEER) database. Results: Among BRCA2 MBCs, grade significantly decreased with increasing age at diagnosis (P = 0.005). Compared with BRCA2 FBCs, BRCA2 MBCs were of significantly higher stage (P for trend = 2 × 10−5) and higher grade (P for trend = 0.005) and were more likely to be oestrogen receptor–positive [odds ratio (OR) 10.59; 95 % confidence interval (CI) 5.15–21.80] and progesterone receptor–positive (OR 5.04; 95 % CI 3.17–8.04). With the exception of grade, similar patterns of associations emerged when we compared BRCA1 MBCs and FBCs. BRCA2 MBCs also presented with higher grade than MBCs from the SEER database (P for trend = 4 × 10−12). Conclusions: On the basis of the largest series analysed to date, our results show that BRCA1/2 MBCs display distinct pathologic characteristics compared with BRCA1/2 FBCs, and we identified a specific BRCA2-associated MBC phenotype characterised by a variable suggesting greater biological aggressiveness (i.e., high histologic grade). These findings could lead to the development of gender-specific risk prediction models and guide clinical strategies appropriate for MBC management."^^ . "2016" . . "18" . "15" . . "BioMed Central"^^ . . . "Breast Cancer Research"^^ . . . "1465542X" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Andrea"^^ . "Gehrig"^^ . "Andrea Gehrig"^^ . . "Kenneth"^^ . "Offit"^^ . "Kenneth Offit"^^ . . "Pedro"^^ . "Perez Segura"^^ . "Pedro Perez Segura"^^ . . "Adalgeir"^^ . "Arason"^^ . "Adalgeir Arason"^^ . . "Esther M."^^ . "John"^^ . "Esther M. John"^^ . . "Orland"^^ . "Diez"^^ . "Orland Diez"^^ . . "Edith"^^ . "Olah"^^ . "Edith Olah"^^ . . "Jan"^^ . "Lubinski"^^ . "Jan Lubinski"^^ . . "Rosa B."^^ . "Barkardottir"^^ . "Rosa B. Barkardottir"^^ . . "Gero"^^ . "Kramer"^^ . "Gero Kramer"^^ . . "Bernardo"^^ . "Bonanni"^^ . "Bernardo Bonanni"^^ . . "Laura"^^ . "Matricardi"^^ . "Laura Matricardi"^^ . . "Janos"^^ . "Papp"^^ . "Janos Papp"^^ . . "Manuel R."^^ . "Teixeira"^^ . "Manuel R. Teixeira"^^ . . "Oskar Tt."^^ . "Johannsson"^^ . "Oskar Tt. Johannsson"^^ . . "Doris"^^ . "Steinemann"^^ . "Doris Steinemann"^^ . . "Saundra S."^^ . "Buys"^^ . "Saundra S. Buys"^^ . . "Jeffrey N."^^ . "Weitzel"^^ . "Jeffrey N. Weitzel"^^ . . "Kathleen B. M."^^ . "Claes"^^ . "Kathleen B. M. Claes"^^ . . "Gabriella"^^ . "Ivady"^^ . "Gabriella Ivady"^^ . . "Miguel Angel"^^ . "Pujana"^^ . "Miguel Angel Pujana"^^ . . "Daniel"^^ . "Barrowdale"^^ . "Daniel Barrowdale"^^ . . "Florentia"^^ . "Fostira"^^ . "Florentia Fostira"^^ . . "Ava"^^ . "Kwong"^^ . "Ava Kwong"^^ . . "Lauren"^^ . "Jacobs"^^ . "Lauren Jacobs"^^ . . "Steve"^^ . "Ellis"^^ . "Steve Ellis"^^ . . "Angel"^^ . "Izquierdo"^^ . "Angel Izquierdo"^^ . . "Mary B."^^ . "Terry"^^ . "Mary B. Terry"^^ . . "Marco"^^ . "Montagna"^^ . "Marco Montagna"^^ . . "Kristin K."^^ . "Zorn"^^ . "Kristin K. Zorn"^^ . . "Tom"^^ . "van Maerken"^^ . "Tom van Maerken"^^ . . "Timothy R."^^ . "Rebbeck"^^ . "Timothy R. Rebbeck"^^ . . "Debra"^^ . "Frost"^^ . "Debra Frost"^^ . . "Priyanka"^^ . "Sharma"^^ . "Priyanka Sharma"^^ . . "Ines"^^ . "Zanna"^^ . "Ines Zanna"^^ . . "Stefania"^^ . "Tommasi"^^ . "Stefania Tommasi"^^ . . "Natalie J."^^ . "Carter"^^ . "Natalie J. Carter"^^ . . "Darcy L."^^ . "Thull"^^ . "Darcy L. Thull"^^ . . "Norbert"^^ . "Arnold"^^ . "Norbert Arnold"^^ . . "Gord"^^ . "Glendon"^^ . "Gord Glendon"^^ . . "Pedro"^^ . "Pinto"^^ . "Pedro Pinto"^^ . . "Alfons"^^ . "Meindl"^^ . "Alfons Meindl"^^ . . "Laura"^^ . "Papi"^^ . "Laura Papi"^^ . . "Thomas V. O."^^ . "Hansen"^^ . "Thomas V. O. Hansen"^^ . . "Dorothea"^^ . "Wand"^^ . "Dorothea Wand"^^ . . "Georgia"^^ . "Chenevix-Trench"^^ . "Georgia Chenevix-Trench"^^ . . "Peter J."^^ . "Hulick"^^ . "Peter J. Hulick"^^ . . "Judy"^^ . "Garber"^^ . "Judy Garber"^^ . . "Susan M."^^ . "Domchek"^^ . "Susan M. Domchek"^^ . . "Andrew K."^^ . "Godwin"^^ . "Andrew K. Godwin"^^ . . "Olufunmilayo I."^^ . "Olopade"^^ . "Olufunmilayo I. Olopade"^^ . . "Dieter"^^ . "Niederacher"^^ . "Dieter Niederacher"^^ . . "Sue"^^ . "Healey"^^ . "Sue Healey"^^ . . "Paul"^^ . "James"^^ . "Paul James"^^ . . "Maria A."^^ . "Caligo"^^ . "Maria A. Caligo"^^ . . "Kathryn J."^^ . "Ruddy"^^ . "Kathryn J. Ruddy"^^ . . "Ana"^^ . "Osorio"^^ . "Ana Osorio"^^ . . "Laure"^^ . "Barjhoux"^^ . "Laure Barjhoux"^^ . . "Ute"^^ . "Hamann"^^ . "Ute Hamann"^^ . . "Muriel"^^ . "Belotti"^^ . "Muriel Belotti"^^ . . "Johanna"^^ . "Rantala"^^ . "Johanna Rantala"^^ . . "Ros"^^ . "Eeles"^^ . "Ros Eeles"^^ . . "Mads"^^ . "Thomassen"^^ . "Mads Thomassen"^^ . . "Lenka"^^ . "Foretova"^^ . "Lenka Foretova"^^ . . "Piera"^^ . "Rizzolo"^^ . "Piera Rizzolo"^^ . . "Antonis C."^^ . "Antoniou"^^ . "Antonis C. Antoniou"^^ . . "David E."^^ . "Goldgar"^^ . "David E. Goldgar"^^ . . "Sook-Yee"^^ . "Yoon"^^ . "Sook-Yee Yoon"^^ . . "Jo"^^ . "Perkins"^^ . "Jo Perkins"^^ . . "Domenico"^^ . "Palli"^^ . "Domenico Palli"^^ . . "Irene L."^^ . "Andrulis"^^ . "Irene L. Andrulis"^^ . . "Anita"^^ . "Bane"^^ . "Anita Bane"^^ . . "Javier"^^ . "Benitez"^^ . "Javier Benitez"^^ . . "Dominique"^^ . "Stoppa-Lyonnet"^^ . "Dominique Stoppa-Lyonnet"^^ . . "Emily"^^ . "Hallberg"^^ . "Emily Hallberg"^^ . . "Bent"^^ . "Ejlertsen"^^ . "Bent Ejlertsen"^^ . . "Mark"^^ . "Robson"^^ . "Mark Robson"^^ . . "Laura"^^ . "Ottini"^^ . "Laura Ottini"^^ . . "Fergus J."^^ . "Couch"^^ . "Fergus J. Couch"^^ . . "Louise"^^ . "Izatt"^^ . "Louise Izatt"^^ . . "Anders"^^ . "Bojesen"^^ . "Anders Bojesen"^^ . . "Valentina"^^ . "Silvestri"^^ . "Valentina Silvestri"^^ . . "Evgeny N."^^ . "Imyanitov"^^ . "Evgeny N. Imyanitov"^^ . . "Paolo"^^ . "Peterlongo"^^ . "Paolo Peterlongo"^^ . . "Bernard"^^ . "Peissel"^^ . "Bernard Peissel"^^ . . "D. Gareth"^^ . "Evans"^^ . "D. Gareth Evans"^^ . . "Susan L."^^ . "Neuhausen"^^ . "Susan L. Neuhausen"^^ . . "Valeria"^^ . "Pensotti"^^ . "Valeria Pensotti"^^ . . "Eva"^^ . "Machackova"^^ . "Eva Machackova"^^ . . "Antonella"^^ . "Savarese"^^ . "Antonella Savarese"^^ . . "Antonio"^^ . "Russo"^^ . "Antonio Russo"^^ . . "Marie"^^ . "Navratilova"^^ . "Marie Navratilova"^^ . . "Eric"^^ . "Hahnen"^^ . "Eric Hahnen"^^ . . "Anna Marie"^^ . "Mulligan"^^ . "Anna Marie Mulligan"^^ . . "Lesley"^^ . "McGuffog"^^ . "Lesley McGuffog"^^ . . "Petra"^^ . "Vasickova"^^ . "Petra Vasickova"^^ . . "Mary B."^^ . "Daly"^^ . "Mary B. Daly"^^ . . "Joseph"^^ . "Vijai"^^ . "Joseph Vijai"^^ . . "Giuseppe"^^ . "Giannini"^^ . "Giuseppe Giannini"^^ . . "Anna"^^ . "Jakubowska"^^ . "Anna Jakubowska"^^ . . "Stephen"^^ . "Fox"^^ . "Stephen Fox"^^ . . "Katherine L."^^ . "Nathanson"^^ . "Katherine L. Nathanson"^^ . . "Phuong L."^^ . "Mai"^^ . "Phuong L. Mai"^^ . . "Mark H."^^ . "Greene"^^ . "Mark H. Greene"^^ . . "Beth Y."^^ . "Karlan"^^ . "Beth Y. Karlan"^^ . . "Trinidad"^^ . "Caldes"^^ . "Trinidad Caldes"^^ . . "Leigha"^^ . "Senter"^^ . "Leigha Senter"^^ . . "Susan J."^^ . "Ramus"^^ . "Susan J. Ramus"^^ . . "Christoph"^^ . "Engel"^^ . "Christoph Engel"^^ . . "Camille"^^ . "Elan"^^ . "Camille Elan"^^ . . "Paolo"^^ . "Radice"^^ . "Paolo Radice"^^ . . "Monica"^^ . "Barile"^^ . "Monica Barile"^^ . . "Sung-Won"^^ . "Kim"^^ . "Sung-Won Kim"^^ . . "Claudine"^^ . "Isaacs"^^ . "Claudine Isaacs"^^ . . "Christine"^^ . "Lasset"^^ . "Christine Lasset"^^ . . "Amanda"^^ . "Ewart Toland"^^ . "Amanda Ewart Toland"^^ . . "Laura"^^ . "Cortesi"^^ . "Laura Cortesi"^^ . . "Christian"^^ . "Sutter"^^ . "Christian Sutter"^^ . . "Anne-Marie"^^ . "Gerdes"^^ . "Anne-Marie Gerdes"^^ . . "Judith"^^ . "Balmaña"^^ . "Judith Balmaña"^^ . . "Nadine"^^ . "Tung"^^ . "Nadine Tung"^^ . . "Christian F."^^ . "Singer"^^ . "Christian F. Singer"^^ . . "Yuan Chun"^^ . "Ding"^^ . "Yuan Chun Ding"^^ . . "Gillian"^^ . "Mitchell"^^ . "Gillian Mitchell"^^ . . "Karin"^^ . "Kast"^^ . "Karin Kast"^^ . . "Heli"^^ . "Nevanlinna"^^ . "Heli Nevanlinna"^^ . . "George"^^ . "Fountzilas"^^ . "George Fountzilas"^^ . . "Radka"^^ . "Platte"^^ . "Radka Platte"^^ . . "Bruce"^^ . "Poppe"^^ . "Bruce Poppe"^^ . . "Linda"^^ . "Steele"^^ . "Linda Steele"^^ . . "Laura"^^ . "Spugnesi"^^ . "Laura Spugnesi"^^ . . "Ramunas"^^ . "Janavicius"^^ . "Ramunas Janavicius"^^ . . "Melissa"^^ . "Southey"^^ . "Melissa Southey"^^ . . "Robert L."^^ . "Nussbaum"^^ . "Robert L. Nussbaum"^^ . . "Uffe Birk"^^ . "Jensen"^^ . "Uffe Birk Jensen"^^ . . "Kristiina"^^ . "Aittomäki"^^ . "Kristiina Aittomäki"^^ . . "Siranoush"^^ . "Manoukian"^^ . "Siranoush Manoukian"^^ . . "Anne"^^ . "Lincoln"^^ . "Anne Lincoln"^^ . . "Douglas F."^^ . "Easton"^^ . "Douglas F. Easton"^^ . . "Alessandra"^^ . "Viel"^^ . "Alessandra Viel"^^ . . "Raymonda"^^ . "Varon-Mateeva"^^ . "Raymonda Varon-Mateeva"^^ . . "Liliana"^^ . "Varesco"^^ . "Liliana Varesco"^^ . . "Barbara"^^ . "Pasini"^^ . "Barbara Pasini"^^ . . "Christine"^^ . "Rappaport-Fuerhauser"^^ . "Christine Rappaport-Fuerhauser"^^ . . "Julian"^^ . "Adlard"^^ . "Julian Adlard"^^ . . "Inge"^^ . "Sokilde Pedersen"^^ . "Inge Sokilde Pedersen"^^ . . . . . . "Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2 (PDF)"^^ . . . "13058_2016_Article_671.pdf"^^ . . . "Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2 (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2 (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2 (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2 (Other)"^^ . . . . . . "small.jpg"^^ . . . "Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2 (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #20247 \n\nMale breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2\n\n" . "text/html" . . . "610 Medizin"@de . "610 Medical sciences Medicine"@en . .