<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2"^^ . "Background: BRCA1 and, more commonly, BRCA2 mutations are associated with increased risk of male breast cancer (MBC). However, only a paucity of data exists on the pathology of breast cancers (BCs) in men with BRCA1/2 mutations. Using the largest available dataset, we determined whether MBCs arising in BRCA1/2 mutation carriers display specific pathologic features and whether these features differ from those of BRCA1/2 female BCs (FBCs). Methods: We characterised the pathologic features of 419 BRCA1/2 MBCs and, using logistic regression analysis, contrasted those with data from 9675 BRCA1/2 FBCs and with population-based data from 6351 MBCs in the Surveillance, Epidemiology, and End Results (SEER) database. Results: Among BRCA2 MBCs, grade significantly decreased with increasing age at diagnosis (P = 0.005). Compared with BRCA2 FBCs, BRCA2 MBCs were of significantly higher stage (P for trend = 2 × 10−5) and higher grade (P for trend = 0.005) and were more likely to be oestrogen receptor–positive [odds ratio (OR) 10.59; 95 % confidence interval (CI) 5.15–21.80] and progesterone receptor–positive (OR 5.04; 95 % CI 3.17–8.04). With the exception of grade, similar patterns of associations emerged when we compared BRCA1 MBCs and FBCs. BRCA2 MBCs also presented with higher grade than MBCs from the SEER database (P for trend = 4 × 10−12). Conclusions: On the basis of the largest series analysed to date, our results show that BRCA1/2 MBCs display distinct pathologic characteristics compared with BRCA1/2 FBCs, and we identified a specific BRCA2-associated MBC phenotype characterised by a variable suggesting greater biological aggressiveness (i.e., high histologic grade). These findings could lead to the development of gender-specific risk prediction models and guide clinical strategies appropriate for MBC management."^^ . "2016" . . "18" . "15" . . "BioMed Central"^^ . . . "Breast Cancer Research"^^ . . . "1465542X" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Valentina"^^ . "Silvestri"^^ . "Valentina Silvestri"^^ . . "Andrea"^^ . "Gehrig"^^ . "Andrea Gehrig"^^ . . "Ros"^^ . "Eeles"^^ . "Ros Eeles"^^ . . "Christian"^^ . "Sutter"^^ . "Christian Sutter"^^ . . "Christine"^^ . "Rappaport-Fuerhauser"^^ . "Christine Rappaport-Fuerhauser"^^ . . "Debra"^^ . "Frost"^^ . "Debra Frost"^^ . . "Evgeny N."^^ . "Imyanitov"^^ . "Evgeny N. Imyanitov"^^ . . "Christoph"^^ . "Engel"^^ . "Christoph Engel"^^ . . "Emily"^^ . "Hallberg"^^ . "Emily Hallberg"^^ . . "Melissa"^^ . "Southey"^^ . "Melissa Southey"^^ . . "Maria A."^^ . "Caligo"^^ . "Maria A. Caligo"^^ . . "Paul"^^ . "James"^^ . "Paul James"^^ . . "Pedro"^^ . "Pinto"^^ . "Pedro Pinto"^^ . . "Edith"^^ . "Olah"^^ . "Edith Olah"^^ . . "Tom"^^ . "van Maerken"^^ . "Tom van Maerken"^^ . . "Laura"^^ . "Cortesi"^^ . "Laura Cortesi"^^ . . "Nadine"^^ . "Tung"^^ . "Nadine Tung"^^ . . "Florentia"^^ . "Fostira"^^ . "Florentia Fostira"^^ . . "Anna"^^ . "Jakubowska"^^ . "Anna Jakubowska"^^ . . "Anders"^^ . "Bojesen"^^ . "Anders Bojesen"^^ . . "Angel"^^ . "Izquierdo"^^ . "Angel Izquierdo"^^ . . "Inge"^^ . "Sokilde Pedersen"^^ . "Inge Sokilde Pedersen"^^ . . "Marco"^^ . "Montagna"^^ . "Marco Montagna"^^ . . "Beth Y."^^ . "Karlan"^^ . "Beth Y. Karlan"^^ . . "Eric"^^ . "Hahnen"^^ . "Eric Hahnen"^^ . . "Karin"^^ . "Kast"^^ . "Karin Kast"^^ . . "Peter J."^^ . "Hulick"^^ . "Peter J. Hulick"^^ . . "Alfons"^^ . "Meindl"^^ . "Alfons Meindl"^^ . . "Anne-Marie"^^ . "Gerdes"^^ . "Anne-Marie Gerdes"^^ . . "Gabriella"^^ . "Ivady"^^ . "Gabriella Ivady"^^ . . "Natalie J."^^ . "Carter"^^ . "Natalie J. Carter"^^ . . "Stephen"^^ . "Fox"^^ . "Stephen Fox"^^ . . "Judy"^^ . "Garber"^^ . "Judy Garber"^^ . . "Miguel Angel"^^ . "Pujana"^^ . "Miguel Angel Pujana"^^ . . "Jeffrey N."^^ . "Weitzel"^^ . "Jeffrey N. Weitzel"^^ . . "Ana"^^ . "Osorio"^^ . "Ana Osorio"^^ . . "Amanda"^^ . "Ewart Toland"^^ . "Amanda Ewart Toland"^^ . . "Timothy R."^^ . "Rebbeck"^^ . "Timothy R. Rebbeck"^^ . . "Sook-Yee"^^ . "Yoon"^^ . "Sook-Yee Yoon"^^ . . "Johanna"^^ . "Rantala"^^ . "Johanna Rantala"^^ . . "Judith"^^ . "Balmaña"^^ . "Judith Balmaña"^^ . . "Alessandra"^^ . "Viel"^^ . "Alessandra Viel"^^ . . "Bernard"^^ . "Peissel"^^ . "Bernard Peissel"^^ . . "Priyanka"^^ . "Sharma"^^ . "Priyanka Sharma"^^ . . "Jan"^^ . "Lubinski"^^ . "Jan Lubinski"^^ . . "Paolo"^^ . "Peterlongo"^^ . "Paolo Peterlongo"^^ . . "Monica"^^ . "Barile"^^ . "Monica Barile"^^ . . "Laura"^^ . "Ottini"^^ . "Laura Ottini"^^ . . "Norbert"^^ . "Arnold"^^ . "Norbert Arnold"^^ . . "Doris"^^ . "Steinemann"^^ . "Doris Steinemann"^^ . . "Dorothea"^^ . "Wand"^^ . "Dorothea Wand"^^ . . "Lauren"^^ . "Jacobs"^^ . "Lauren Jacobs"^^ . . "Claudine"^^ . "Isaacs"^^ . "Claudine Isaacs"^^ . . "Orland"^^ . "Diez"^^ . "Orland Diez"^^ . . "D. Gareth"^^ . "Evans"^^ . "D. Gareth Evans"^^ . . "Antonio"^^ . "Russo"^^ . "Antonio Russo"^^ . . "Laura"^^ . "Matricardi"^^ . "Laura Matricardi"^^ . . "Gillian"^^ . "Mitchell"^^ . "Gillian Mitchell"^^ . . "Antonis C."^^ . "Antoniou"^^ . "Antonis C. Antoniou"^^ . . "Laura"^^ . "Spugnesi"^^ . "Laura Spugnesi"^^ . . "Petra"^^ . "Vasickova"^^ . "Petra Vasickova"^^ . . "Lesley"^^ . "McGuffog"^^ . "Lesley McGuffog"^^ . . "Darcy L."^^ . "Thull"^^ . "Darcy L. Thull"^^ . . "Bruce"^^ . "Poppe"^^ . "Bruce Poppe"^^ . . "Javier"^^ . "Benitez"^^ . "Javier Benitez"^^ . . "Ramunas"^^ . "Janavicius"^^ . "Ramunas Janavicius"^^ . . "Anna Marie"^^ . "Mulligan"^^ . "Anna Marie Mulligan"^^ . . "Antonella"^^ . "Savarese"^^ . "Antonella Savarese"^^ . . "Susan M."^^ . "Domchek"^^ . "Susan M. Domchek"^^ . . "Paolo"^^ . "Radice"^^ . "Paolo Radice"^^ . . "Anita"^^ . "Bane"^^ . "Anita Bane"^^ . . "Mary B."^^ . "Terry"^^ . "Mary B. Terry"^^ . . "Jo"^^ . "Perkins"^^ . "Jo Perkins"^^ . . "Douglas F."^^ . "Easton"^^ . "Douglas F. Easton"^^ . . "Yuan Chun"^^ . "Ding"^^ . "Yuan Chun Ding"^^ . . "Manuel R."^^ . "Teixeira"^^ . "Manuel R. Teixeira"^^ . . "Linda"^^ . "Steele"^^ . "Linda Steele"^^ . . "Raymonda"^^ . "Varon-Mateeva"^^ . "Raymonda Varon-Mateeva"^^ . . "Stefania"^^ . "Tommasi"^^ . "Stefania Tommasi"^^ . . "Uffe Birk"^^ . "Jensen"^^ . "Uffe Birk Jensen"^^ . . "Trinidad"^^ . "Caldes"^^ . "Trinidad Caldes"^^ . . "Gord"^^ . "Glendon"^^ . "Gord Glendon"^^ . . "Anne"^^ . "Lincoln"^^ . "Anne Lincoln"^^ . . "Kathleen B. M."^^ . "Claes"^^ . "Kathleen B. M. Claes"^^ . . "Christine"^^ . "Lasset"^^ . "Christine Lasset"^^ . . "Lenka"^^ . "Foretova"^^ . "Lenka Foretova"^^ . . "Mary B."^^ . "Daly"^^ . "Mary B. Daly"^^ . . "Rosa B."^^ . "Barkardottir"^^ . "Rosa B. Barkardottir"^^ . . "Liliana"^^ . "Varesco"^^ . "Liliana Varesco"^^ . . "Gero"^^ . "Kramer"^^ . "Gero Kramer"^^ . . "Pedro"^^ . "Perez Segura"^^ . "Pedro Perez Segura"^^ . . "Dominique"^^ . "Stoppa-Lyonnet"^^ . "Dominique Stoppa-Lyonnet"^^ . . "Oskar Tt."^^ . "Johannsson"^^ . "Oskar Tt. Johannsson"^^ . . "Christian F."^^ . "Singer"^^ . "Christian F. Singer"^^ . . "David E."^^ . "Goldgar"^^ . "David E. Goldgar"^^ . . "Mark"^^ . "Robson"^^ . "Mark Robson"^^ . . "George"^^ . "Fountzilas"^^ . "George Fountzilas"^^ . . "Esther M."^^ . "John"^^ . "Esther M. John"^^ . . "Louise"^^ . "Izatt"^^ . "Louise Izatt"^^ . . "Laure"^^ . "Barjhoux"^^ . "Laure Barjhoux"^^ . . "Joseph"^^ . "Vijai"^^ . "Joseph Vijai"^^ . . "Phuong L."^^ . "Mai"^^ . "Phuong L. Mai"^^ . . "Saundra S."^^ . "Buys"^^ . "Saundra S. Buys"^^ . . "Kathryn J."^^ . "Ruddy"^^ . "Kathryn J. Ruddy"^^ . . "Leigha"^^ . "Senter"^^ . "Leigha Senter"^^ . . "Julian"^^ . "Adlard"^^ . "Julian Adlard"^^ . . "Steve"^^ . "Ellis"^^ . "Steve Ellis"^^ . . "Andrew K."^^ . "Godwin"^^ . "Andrew K. Godwin"^^ . . "Bernardo"^^ . "Bonanni"^^ . "Bernardo Bonanni"^^ . . "Ines"^^ . "Zanna"^^ . "Ines Zanna"^^ . . "Fergus J."^^ . "Couch"^^ . "Fergus J. Couch"^^ . . "Piera"^^ . "Rizzolo"^^ . "Piera Rizzolo"^^ . . "Kristin K."^^ . "Zorn"^^ . "Kristin K. Zorn"^^ . . "Giuseppe"^^ . "Giannini"^^ . "Giuseppe Giannini"^^ . . "Sue"^^ . "Healey"^^ . "Sue Healey"^^ . . "Thomas V. O."^^ . "Hansen"^^ . "Thomas V. O. Hansen"^^ . . "Sung-Won"^^ . "Kim"^^ . "Sung-Won Kim"^^ . . "Ava"^^ . "Kwong"^^ . "Ava Kwong"^^ . . "Laura"^^ . "Papi"^^ . "Laura Papi"^^ . . "Mads"^^ . "Thomassen"^^ . "Mads Thomassen"^^ . . "Radka"^^ . "Platte"^^ . "Radka Platte"^^ . . "Susan J."^^ . "Ramus"^^ . "Susan J. Ramus"^^ . . "Kenneth"^^ . "Offit"^^ . "Kenneth Offit"^^ . . "Irene L."^^ . "Andrulis"^^ . "Irene L. Andrulis"^^ . . "Heli"^^ . "Nevanlinna"^^ . "Heli Nevanlinna"^^ . . "Dieter"^^ . "Niederacher"^^ . "Dieter Niederacher"^^ . . "Susan L."^^ . "Neuhausen"^^ . "Susan L. Neuhausen"^^ . . "Valeria"^^ . "Pensotti"^^ . "Valeria Pensotti"^^ . . "Robert L."^^ . "Nussbaum"^^ . "Robert L. Nussbaum"^^ . . "Barbara"^^ . "Pasini"^^ . "Barbara Pasini"^^ . . "Camille"^^ . "Elan"^^ . "Camille Elan"^^ . . "Eva"^^ . "Machackova"^^ . "Eva Machackova"^^ . . "Katherine L."^^ . "Nathanson"^^ . "Katherine L. Nathanson"^^ . . "Kristiina"^^ . "Aittomäki"^^ . "Kristiina Aittomäki"^^ . . "Janos"^^ . "Papp"^^ . "Janos Papp"^^ . . "Adalgeir"^^ . "Arason"^^ . "Adalgeir Arason"^^ . . "Siranoush"^^ . "Manoukian"^^ . "Siranoush Manoukian"^^ . . "Olufunmilayo I."^^ . "Olopade"^^ . "Olufunmilayo I. Olopade"^^ . . "Bent"^^ . "Ejlertsen"^^ . "Bent Ejlertsen"^^ . . "Georgia"^^ . "Chenevix-Trench"^^ . "Georgia Chenevix-Trench"^^ . . "Mark H."^^ . "Greene"^^ . "Mark H. Greene"^^ . . "Domenico"^^ . "Palli"^^ . "Domenico Palli"^^ . . "Muriel"^^ . "Belotti"^^ . "Muriel Belotti"^^ . . "Marie"^^ . "Navratilova"^^ . "Marie Navratilova"^^ . . "Daniel"^^ . "Barrowdale"^^ . "Daniel Barrowdale"^^ . . "Ute"^^ . "Hamann"^^ . "Ute Hamann"^^ . . . . . . "Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2 (PDF)"^^ . . . "13058_2016_Article_671.pdf"^^ . . . "Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2 (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2 (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2 (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2 (Other)"^^ . . . . . . "small.jpg"^^ . . . "Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2 (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #20247 \n\nMale breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2\n\n" . "text/html" . . . "610 Medizin"@de . "610 Medical sciences Medicine"@en . .