<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2"^^ . "Background: BRCA1 and, more commonly, BRCA2 mutations are associated with increased risk of male breast cancer (MBC). However, only a paucity of data exists on the pathology of breast cancers (BCs) in men with BRCA1/2 mutations. Using the largest available dataset, we determined whether MBCs arising in BRCA1/2 mutation carriers display specific pathologic features and whether these features differ from those of BRCA1/2 female BCs (FBCs). Methods: We characterised the pathologic features of 419 BRCA1/2 MBCs and, using logistic regression analysis, contrasted those with data from 9675 BRCA1/2 FBCs and with population-based data from 6351 MBCs in the Surveillance, Epidemiology, and End Results (SEER) database. Results: Among BRCA2 MBCs, grade significantly decreased with increasing age at diagnosis (P = 0.005). Compared with BRCA2 FBCs, BRCA2 MBCs were of significantly higher stage (P for trend = 2 × 10−5) and higher grade (P for trend = 0.005) and were more likely to be oestrogen receptor–positive [odds ratio (OR) 10.59; 95 % confidence interval (CI) 5.15–21.80] and progesterone receptor–positive (OR 5.04; 95 % CI 3.17–8.04). With the exception of grade, similar patterns of associations emerged when we compared BRCA1 MBCs and FBCs. BRCA2 MBCs also presented with higher grade than MBCs from the SEER database (P for trend = 4 × 10−12). Conclusions: On the basis of the largest series analysed to date, our results show that BRCA1/2 MBCs display distinct pathologic characteristics compared with BRCA1/2 FBCs, and we identified a specific BRCA2-associated MBC phenotype characterised by a variable suggesting greater biological aggressiveness (i.e., high histologic grade). These findings could lead to the development of gender-specific risk prediction models and guide clinical strategies appropriate for MBC management."^^ . "2016" . . "18" . "15" . . "BioMed Central"^^ . . . "Breast Cancer Research"^^ . . . "1465542X" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Javier"^^ . "Benitez"^^ . "Javier Benitez"^^ . . "Angel"^^ . "Izquierdo"^^ . "Angel Izquierdo"^^ . . "Eva"^^ . "Machackova"^^ . "Eva Machackova"^^ . . "D. Gareth"^^ . "Evans"^^ . "D. Gareth Evans"^^ . . "Susan J."^^ . "Ramus"^^ . "Susan J. Ramus"^^ . . "Dieter"^^ . "Niederacher"^^ . "Dieter Niederacher"^^ . . "Susan M."^^ . "Domchek"^^ . "Susan M. Domchek"^^ . . "Kathryn J."^^ . "Ruddy"^^ . "Kathryn J. Ruddy"^^ . . "Pedro"^^ . "Perez Segura"^^ . "Pedro Perez Segura"^^ . . "Fergus J."^^ . "Couch"^^ . "Fergus J. Couch"^^ . . "George"^^ . "Fountzilas"^^ . "George Fountzilas"^^ . . "Mary B."^^ . "Terry"^^ . "Mary B. Terry"^^ . . "Mads"^^ . "Thomassen"^^ . "Mads Thomassen"^^ . . "Marco"^^ . "Montagna"^^ . "Marco Montagna"^^ . . "Laura"^^ . "Ottini"^^ . "Laura Ottini"^^ . . "Susan L."^^ . "Neuhausen"^^ . "Susan L. Neuhausen"^^ . . "Christoph"^^ . "Engel"^^ . "Christoph Engel"^^ . . "Debra"^^ . "Frost"^^ . "Debra Frost"^^ . . "Emily"^^ . "Hallberg"^^ . "Emily Hallberg"^^ . . "Lesley"^^ . "McGuffog"^^ . "Lesley McGuffog"^^ . . "Kristiina"^^ . "Aittomäki"^^ . "Kristiina Aittomäki"^^ . . "Antonis C."^^ . "Antoniou"^^ . "Antonis C. Antoniou"^^ . . "Melissa"^^ . "Southey"^^ . "Melissa Southey"^^ . . "Rosa B."^^ . "Barkardottir"^^ . "Rosa B. Barkardottir"^^ . . "Irene L."^^ . "Andrulis"^^ . "Irene L. Andrulis"^^ . . "Jeffrey N."^^ . "Weitzel"^^ . "Jeffrey N. Weitzel"^^ . . "Anne"^^ . "Lincoln"^^ . "Anne Lincoln"^^ . . "Gabriella"^^ . "Ivady"^^ . "Gabriella Ivady"^^ . . "Dominique"^^ . "Stoppa-Lyonnet"^^ . "Dominique Stoppa-Lyonnet"^^ . . "Judith"^^ . "Balmaña"^^ . "Judith Balmaña"^^ . . "Andrew K."^^ . "Godwin"^^ . "Andrew K. Godwin"^^ . . "Gero"^^ . "Kramer"^^ . "Gero Kramer"^^ . . "Katherine L."^^ . "Nathanson"^^ . "Katherine L. Nathanson"^^ . . "Laura"^^ . "Spugnesi"^^ . "Laura Spugnesi"^^ . . "Ava"^^ . "Kwong"^^ . "Ava Kwong"^^ . . "Valentina"^^ . "Silvestri"^^ . "Valentina Silvestri"^^ . . "Louise"^^ . "Izatt"^^ . "Louise Izatt"^^ . . "Adalgeir"^^ . "Arason"^^ . "Adalgeir Arason"^^ . . "Bernard"^^ . "Peissel"^^ . "Bernard Peissel"^^ . . "Saundra S."^^ . "Buys"^^ . "Saundra S. Buys"^^ . . "Heli"^^ . "Nevanlinna"^^ . "Heli Nevanlinna"^^ . . "Linda"^^ . "Steele"^^ . "Linda Steele"^^ . . "Robert L."^^ . "Nussbaum"^^ . "Robert L. Nussbaum"^^ . . "Giuseppe"^^ . "Giannini"^^ . "Giuseppe Giannini"^^ . . "Anna"^^ . "Jakubowska"^^ . "Anna Jakubowska"^^ . . "Gord"^^ . "Glendon"^^ . "Gord Glendon"^^ . . "Kathleen B. M."^^ . "Claes"^^ . "Kathleen B. M. Claes"^^ . . "Yuan Chun"^^ . "Ding"^^ . "Yuan Chun Ding"^^ . . "Eric"^^ . "Hahnen"^^ . "Eric Hahnen"^^ . . "Trinidad"^^ . "Caldes"^^ . "Trinidad Caldes"^^ . . "Anna Marie"^^ . "Mulligan"^^ . "Anna Marie Mulligan"^^ . . "Jan"^^ . "Lubinski"^^ . "Jan Lubinski"^^ . . "Lenka"^^ . "Foretova"^^ . "Lenka Foretova"^^ . . "Florentia"^^ . "Fostira"^^ . "Florentia Fostira"^^ . . "Norbert"^^ . "Arnold"^^ . "Norbert Arnold"^^ . . "Stephen"^^ . "Fox"^^ . "Stephen Fox"^^ . . "Christine"^^ . "Rappaport-Fuerhauser"^^ . "Christine Rappaport-Fuerhauser"^^ . . "Laura"^^ . "Papi"^^ . "Laura Papi"^^ . . "Johanna"^^ . "Rantala"^^ . "Johanna Rantala"^^ . . "Thomas V. O."^^ . "Hansen"^^ . "Thomas V. O. Hansen"^^ . . "Bruce"^^ . "Poppe"^^ . "Bruce Poppe"^^ . . "Siranoush"^^ . "Manoukian"^^ . "Siranoush Manoukian"^^ . . "Piera"^^ . "Rizzolo"^^ . "Piera Rizzolo"^^ . . "Uffe Birk"^^ . "Jensen"^^ . "Uffe Birk Jensen"^^ . . "Bent"^^ . "Ejlertsen"^^ . "Bent Ejlertsen"^^ . . "Phuong L."^^ . "Mai"^^ . "Phuong L. Mai"^^ . . "Darcy L."^^ . "Thull"^^ . "Darcy L. Thull"^^ . . "Jo"^^ . "Perkins"^^ . "Jo Perkins"^^ . . "Doris"^^ . "Steinemann"^^ . "Doris Steinemann"^^ . . "Barbara"^^ . "Pasini"^^ . "Barbara Pasini"^^ . . "Christian"^^ . "Sutter"^^ . "Christian Sutter"^^ . . "Antonella"^^ . "Savarese"^^ . "Antonella Savarese"^^ . . "Dorothea"^^ . "Wand"^^ . "Dorothea Wand"^^ . . "Maria A."^^ . "Caligo"^^ . "Maria A. Caligo"^^ . . "Manuel R."^^ . "Teixeira"^^ . "Manuel R. Teixeira"^^ . . "Ana"^^ . "Osorio"^^ . "Ana Osorio"^^ . . "Mark"^^ . "Robson"^^ . "Mark Robson"^^ . . "Georgia"^^ . "Chenevix-Trench"^^ . "Georgia Chenevix-Trench"^^ . . "Lauren"^^ . "Jacobs"^^ . "Lauren Jacobs"^^ . . "Anita"^^ . "Bane"^^ . "Anita Bane"^^ . . "Julian"^^ . "Adlard"^^ . "Julian Adlard"^^ . . "Mary B."^^ . "Daly"^^ . "Mary B. Daly"^^ . . "Mark H."^^ . "Greene"^^ . "Mark H. Greene"^^ . . "Domenico"^^ . "Palli"^^ . "Domenico Palli"^^ . . "Sook-Yee"^^ . "Yoon"^^ . "Sook-Yee Yoon"^^ . . "Christian F."^^ . "Singer"^^ . "Christian F. Singer"^^ . . "Anne-Marie"^^ . "Gerdes"^^ . "Anne-Marie Gerdes"^^ . . "Kristin K."^^ . "Zorn"^^ . "Kristin K. Zorn"^^ . . "Raymonda"^^ . "Varon-Mateeva"^^ . "Raymonda Varon-Mateeva"^^ . . "Timothy R."^^ . "Rebbeck"^^ . "Timothy R. Rebbeck"^^ . . "Miguel Angel"^^ . "Pujana"^^ . "Miguel Angel Pujana"^^ . . "Monica"^^ . "Barile"^^ . "Monica Barile"^^ . . "Esther M."^^ . "John"^^ . "Esther M. John"^^ . . "Andrea"^^ . "Gehrig"^^ . "Andrea Gehrig"^^ . . "Steve"^^ . "Ellis"^^ . "Steve Ellis"^^ . . "Kenneth"^^ . "Offit"^^ . "Kenneth Offit"^^ . . "Peter J."^^ . "Hulick"^^ . "Peter J. Hulick"^^ . . "Stefania"^^ . "Tommasi"^^ . "Stefania Tommasi"^^ . . "Paolo"^^ . "Peterlongo"^^ . "Paolo Peterlongo"^^ . . "Antonio"^^ . "Russo"^^ . "Antonio Russo"^^ . . "Paul"^^ . "James"^^ . "Paul James"^^ . . "Oskar Tt."^^ . "Johannsson"^^ . "Oskar Tt. Johannsson"^^ . . "Amanda"^^ . "Ewart Toland"^^ . "Amanda Ewart Toland"^^ . . "Tom"^^ . "van Maerken"^^ . "Tom van Maerken"^^ . . "Gillian"^^ . "Mitchell"^^ . "Gillian Mitchell"^^ . . "Ramunas"^^ . "Janavicius"^^ . "Ramunas Janavicius"^^ . . "David E."^^ . "Goldgar"^^ . "David E. Goldgar"^^ . . "Paolo"^^ . "Radice"^^ . "Paolo Radice"^^ . . "Radka"^^ . "Platte"^^ . "Radka Platte"^^ . . "Daniel"^^ . "Barrowdale"^^ . "Daniel Barrowdale"^^ . . "Laure"^^ . "Barjhoux"^^ . "Laure Barjhoux"^^ . . "Alessandra"^^ . "Viel"^^ . "Alessandra Viel"^^ . . "Orland"^^ . "Diez"^^ . "Orland Diez"^^ . . "Edith"^^ . "Olah"^^ . "Edith Olah"^^ . . "Judy"^^ . "Garber"^^ . "Judy Garber"^^ . . "Petra"^^ . "Vasickova"^^ . "Petra Vasickova"^^ . . "Karin"^^ . "Kast"^^ . "Karin Kast"^^ . . "Evgeny N."^^ . "Imyanitov"^^ . "Evgeny N. Imyanitov"^^ . . "Ros"^^ . "Eeles"^^ . "Ros Eeles"^^ . . "Ines"^^ . "Zanna"^^ . "Ines Zanna"^^ . . "Leigha"^^ . "Senter"^^ . "Leigha Senter"^^ . . "Laura"^^ . "Cortesi"^^ . "Laura Cortesi"^^ . . "Natalie J."^^ . "Carter"^^ . "Natalie J. Carter"^^ . . "Ute"^^ . "Hamann"^^ . "Ute Hamann"^^ . . "Alfons"^^ . "Meindl"^^ . "Alfons Meindl"^^ . . "Laura"^^ . "Matricardi"^^ . "Laura Matricardi"^^ . . "Valeria"^^ . "Pensotti"^^ . "Valeria Pensotti"^^ . . "Pedro"^^ . "Pinto"^^ . "Pedro Pinto"^^ . . "Anders"^^ . "Bojesen"^^ . "Anders Bojesen"^^ . . "Camille"^^ . "Elan"^^ . "Camille Elan"^^ . . "Sung-Won"^^ . "Kim"^^ . "Sung-Won Kim"^^ . . "Bernardo"^^ . "Bonanni"^^ . "Bernardo Bonanni"^^ . . "Olufunmilayo I."^^ . "Olopade"^^ . "Olufunmilayo I. Olopade"^^ . . "Priyanka"^^ . "Sharma"^^ . "Priyanka Sharma"^^ . . "Beth Y."^^ . "Karlan"^^ . "Beth Y. Karlan"^^ . . "Joseph"^^ . "Vijai"^^ . "Joseph Vijai"^^ . . "Douglas F."^^ . "Easton"^^ . "Douglas F. Easton"^^ . . "Marie"^^ . "Navratilova"^^ . "Marie Navratilova"^^ . . "Nadine"^^ . "Tung"^^ . "Nadine Tung"^^ . . "Claudine"^^ . "Isaacs"^^ . "Claudine Isaacs"^^ . . "Inge"^^ . "Sokilde Pedersen"^^ . "Inge Sokilde Pedersen"^^ . . "Christine"^^ . "Lasset"^^ . "Christine Lasset"^^ . . "Sue"^^ . "Healey"^^ . "Sue Healey"^^ . . "Muriel"^^ . "Belotti"^^ . "Muriel Belotti"^^ . . "Janos"^^ . "Papp"^^ . "Janos Papp"^^ . . "Liliana"^^ . "Varesco"^^ . "Liliana Varesco"^^ . . . . . . "Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2 (PDF)"^^ . . . "13058_2016_Article_671.pdf"^^ . . . "Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2 (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2 (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2 (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2 (Other)"^^ . . . . . . "small.jpg"^^ . . . "Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2 (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #20247 \n\nMale breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2\n\n" . "text/html" . . . "610 Medizin"@de . "610 Medical sciences Medicine"@en . .