<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2"^^ . "Background: BRCA1 and, more commonly, BRCA2 mutations are associated with increased risk of male breast cancer (MBC). However, only a paucity of data exists on the pathology of breast cancers (BCs) in men with BRCA1/2 mutations. Using the largest available dataset, we determined whether MBCs arising in BRCA1/2 mutation carriers display specific pathologic features and whether these features differ from those of BRCA1/2 female BCs (FBCs). Methods: We characterised the pathologic features of 419 BRCA1/2 MBCs and, using logistic regression analysis, contrasted those with data from 9675 BRCA1/2 FBCs and with population-based data from 6351 MBCs in the Surveillance, Epidemiology, and End Results (SEER) database. Results: Among BRCA2 MBCs, grade significantly decreased with increasing age at diagnosis (P = 0.005). Compared with BRCA2 FBCs, BRCA2 MBCs were of significantly higher stage (P for trend = 2 × 10−5) and higher grade (P for trend = 0.005) and were more likely to be oestrogen receptor–positive [odds ratio (OR) 10.59; 95 % confidence interval (CI) 5.15–21.80] and progesterone receptor–positive (OR 5.04; 95 % CI 3.17–8.04). With the exception of grade, similar patterns of associations emerged when we compared BRCA1 MBCs and FBCs. BRCA2 MBCs also presented with higher grade than MBCs from the SEER database (P for trend = 4 × 10−12). Conclusions: On the basis of the largest series analysed to date, our results show that BRCA1/2 MBCs display distinct pathologic characteristics compared with BRCA1/2 FBCs, and we identified a specific BRCA2-associated MBC phenotype characterised by a variable suggesting greater biological aggressiveness (i.e., high histologic grade). These findings could lead to the development of gender-specific risk prediction models and guide clinical strategies appropriate for MBC management."^^ . "2016" . . "18" . "15" . . "BioMed Central"^^ . . . "Breast Cancer Research"^^ . . . "1465542X" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Thomas V. O."^^ . "Hansen"^^ . "Thomas V. O. Hansen"^^ . . "Darcy L."^^ . "Thull"^^ . "Darcy L. Thull"^^ . . "Pedro"^^ . "Pinto"^^ . "Pedro Pinto"^^ . . "Melissa"^^ . "Southey"^^ . "Melissa Southey"^^ . . "Evgeny N."^^ . "Imyanitov"^^ . "Evgeny N. Imyanitov"^^ . . "Christian F."^^ . "Singer"^^ . "Christian F. Singer"^^ . . "Daniel"^^ . "Barrowdale"^^ . "Daniel Barrowdale"^^ . . "Uffe Birk"^^ . "Jensen"^^ . "Uffe Birk Jensen"^^ . . "Inge"^^ . "Sokilde Pedersen"^^ . "Inge Sokilde Pedersen"^^ . . "Kathryn J."^^ . "Ruddy"^^ . "Kathryn J. Ruddy"^^ . . "Anne"^^ . "Lincoln"^^ . "Anne Lincoln"^^ . . "Mads"^^ . "Thomassen"^^ . "Mads Thomassen"^^ . . "Eva"^^ . "Machackova"^^ . "Eva Machackova"^^ . . "Natalie J."^^ . "Carter"^^ . "Natalie J. Carter"^^ . . "Phuong L."^^ . "Mai"^^ . "Phuong L. Mai"^^ . . "Lenka"^^ . "Foretova"^^ . "Lenka Foretova"^^ . . "Janos"^^ . "Papp"^^ . "Janos Papp"^^ . . "Kristin K."^^ . "Zorn"^^ . "Kristin K. Zorn"^^ . . "Stefania"^^ . "Tommasi"^^ . "Stefania Tommasi"^^ . . "Dieter"^^ . "Niederacher"^^ . "Dieter Niederacher"^^ . . "Gillian"^^ . "Mitchell"^^ . "Gillian Mitchell"^^ . . "Jo"^^ . "Perkins"^^ . "Jo Perkins"^^ . . "Mark"^^ . "Robson"^^ . "Mark Robson"^^ . . "Muriel"^^ . "Belotti"^^ . "Muriel Belotti"^^ . . "Monica"^^ . "Barile"^^ . "Monica Barile"^^ . . "Dominique"^^ . "Stoppa-Lyonnet"^^ . "Dominique Stoppa-Lyonnet"^^ . . "Joseph"^^ . "Vijai"^^ . "Joseph Vijai"^^ . . "Anna"^^ . "Jakubowska"^^ . "Anna Jakubowska"^^ . . "Saundra S."^^ . "Buys"^^ . "Saundra S. Buys"^^ . . "Anna Marie"^^ . "Mulligan"^^ . "Anna Marie Mulligan"^^ . . "Edith"^^ . "Olah"^^ . "Edith Olah"^^ . . "Jan"^^ . "Lubinski"^^ . "Jan Lubinski"^^ . . "Nadine"^^ . "Tung"^^ . "Nadine Tung"^^ . . "Lesley"^^ . "McGuffog"^^ . "Lesley McGuffog"^^ . . "Laura"^^ . "Ottini"^^ . "Laura Ottini"^^ . . "Beth Y."^^ . "Karlan"^^ . "Beth Y. Karlan"^^ . . "Marie"^^ . "Navratilova"^^ . "Marie Navratilova"^^ . . "Ana"^^ . "Osorio"^^ . "Ana Osorio"^^ . . "Katherine L."^^ . "Nathanson"^^ . "Katherine L. Nathanson"^^ . . "Mark H."^^ . "Greene"^^ . "Mark H. Greene"^^ . . "Emily"^^ . "Hallberg"^^ . "Emily Hallberg"^^ . . "Heli"^^ . "Nevanlinna"^^ . "Heli Nevanlinna"^^ . . "Kristiina"^^ . "Aittomäki"^^ . "Kristiina Aittomäki"^^ . . "David E."^^ . "Goldgar"^^ . "David E. Goldgar"^^ . . "Mary B."^^ . "Daly"^^ . "Mary B. Daly"^^ . . "Oskar Tt."^^ . "Johannsson"^^ . "Oskar Tt. Johannsson"^^ . . "Steve"^^ . "Ellis"^^ . "Steve Ellis"^^ . . "Stephen"^^ . "Fox"^^ . "Stephen Fox"^^ . . "Rosa B."^^ . "Barkardottir"^^ . "Rosa B. Barkardottir"^^ . . "Ramunas"^^ . "Janavicius"^^ . "Ramunas Janavicius"^^ . . "Susan M."^^ . "Domchek"^^ . "Susan M. Domchek"^^ . . "Susan L."^^ . "Neuhausen"^^ . "Susan L. Neuhausen"^^ . . "Amanda"^^ . "Ewart Toland"^^ . "Amanda Ewart Toland"^^ . . "Karin"^^ . "Kast"^^ . "Karin Kast"^^ . . "Giuseppe"^^ . "Giannini"^^ . "Giuseppe Giannini"^^ . . "Camille"^^ . "Elan"^^ . "Camille Elan"^^ . . "Judy"^^ . "Garber"^^ . "Judy Garber"^^ . . "Sue"^^ . "Healey"^^ . "Sue Healey"^^ . . "Yuan Chun"^^ . "Ding"^^ . "Yuan Chun Ding"^^ . . "Julian"^^ . "Adlard"^^ . "Julian Adlard"^^ . . "Norbert"^^ . "Arnold"^^ . "Norbert Arnold"^^ . . "Domenico"^^ . "Palli"^^ . "Domenico Palli"^^ . . "Laura"^^ . "Cortesi"^^ . "Laura Cortesi"^^ . . "D. Gareth"^^ . "Evans"^^ . "D. Gareth Evans"^^ . . "Raymonda"^^ . "Varon-Mateeva"^^ . "Raymonda Varon-Mateeva"^^ . . "Liliana"^^ . "Varesco"^^ . "Liliana Varesco"^^ . . "Paolo"^^ . "Radice"^^ . "Paolo Radice"^^ . . "Leigha"^^ . "Senter"^^ . "Leigha Senter"^^ . . "Maria A."^^ . "Caligo"^^ . "Maria A. Caligo"^^ . . "Georgia"^^ . "Chenevix-Trench"^^ . "Georgia Chenevix-Trench"^^ . . "Adalgeir"^^ . "Arason"^^ . "Adalgeir Arason"^^ . . "Robert L."^^ . "Nussbaum"^^ . "Robert L. Nussbaum"^^ . . "Florentia"^^ . "Fostira"^^ . "Florentia Fostira"^^ . . "Olufunmilayo I."^^ . "Olopade"^^ . "Olufunmilayo I. Olopade"^^ . . "Gord"^^ . "Glendon"^^ . "Gord Glendon"^^ . . "Douglas F."^^ . "Easton"^^ . "Douglas F. Easton"^^ . . "Doris"^^ . "Steinemann"^^ . "Doris Steinemann"^^ . . "Jeffrey N."^^ . "Weitzel"^^ . "Jeffrey N. Weitzel"^^ . . "Laure"^^ . "Barjhoux"^^ . "Laure Barjhoux"^^ . . "Laura"^^ . "Matricardi"^^ . "Laura Matricardi"^^ . . "Sook-Yee"^^ . "Yoon"^^ . "Sook-Yee Yoon"^^ . . "Ute"^^ . "Hamann"^^ . "Ute Hamann"^^ . . "George"^^ . "Fountzilas"^^ . "George Fountzilas"^^ . . "Ava"^^ . "Kwong"^^ . "Ava Kwong"^^ . . "Judith"^^ . "Balmaña"^^ . "Judith Balmaña"^^ . . "Laura"^^ . "Papi"^^ . "Laura Papi"^^ . . "Susan J."^^ . "Ramus"^^ . "Susan J. Ramus"^^ . . "Gabriella"^^ . "Ivady"^^ . "Gabriella Ivady"^^ . . "Anita"^^ . "Bane"^^ . "Anita Bane"^^ . . "Christine"^^ . "Lasset"^^ . "Christine Lasset"^^ . . "Bernard"^^ . "Peissel"^^ . "Bernard Peissel"^^ . . "Orland"^^ . "Diez"^^ . "Orland Diez"^^ . . "Anne-Marie"^^ . "Gerdes"^^ . "Anne-Marie Gerdes"^^ . . "Antonio"^^ . "Russo"^^ . "Antonio Russo"^^ . . "Anders"^^ . "Bojesen"^^ . "Anders Bojesen"^^ . . "Paul"^^ . "James"^^ . "Paul James"^^ . . "Johanna"^^ . "Rantala"^^ . "Johanna Rantala"^^ . . "Barbara"^^ . "Pasini"^^ . "Barbara Pasini"^^ . . "Ros"^^ . "Eeles"^^ . "Ros Eeles"^^ . . "Antonella"^^ . "Savarese"^^ . "Antonella Savarese"^^ . . "Fergus J."^^ . "Couch"^^ . "Fergus J. Couch"^^ . . "Javier"^^ . "Benitez"^^ . "Javier Benitez"^^ . . "Ines"^^ . "Zanna"^^ . "Ines Zanna"^^ . . "Valentina"^^ . "Silvestri"^^ . "Valentina Silvestri"^^ . . "Alfons"^^ . "Meindl"^^ . "Alfons Meindl"^^ . . "Debra"^^ . "Frost"^^ . "Debra Frost"^^ . . "Trinidad"^^ . "Caldes"^^ . "Trinidad Caldes"^^ . . "Radka"^^ . "Platte"^^ . "Radka Platte"^^ . . "Sung-Won"^^ . "Kim"^^ . "Sung-Won Kim"^^ . . "Christian"^^ . "Sutter"^^ . "Christian Sutter"^^ . . "Andrea"^^ . "Gehrig"^^ . "Andrea Gehrig"^^ . . "Antonis C."^^ . "Antoniou"^^ . "Antonis C. Antoniou"^^ . . "Mary B."^^ . "Terry"^^ . "Mary B. Terry"^^ . . "Petra"^^ . "Vasickova"^^ . "Petra Vasickova"^^ . . "Andrew K."^^ . "Godwin"^^ . "Andrew K. Godwin"^^ . . "Miguel Angel"^^ . "Pujana"^^ . "Miguel Angel Pujana"^^ . . "Bernardo"^^ . "Bonanni"^^ . "Bernardo Bonanni"^^ . . "Alessandra"^^ . "Viel"^^ . "Alessandra Viel"^^ . . "Bruce"^^ . "Poppe"^^ . "Bruce Poppe"^^ . . "Bent"^^ . "Ejlertsen"^^ . "Bent Ejlertsen"^^ . . "Paolo"^^ . "Peterlongo"^^ . "Paolo Peterlongo"^^ . . "Kenneth"^^ . "Offit"^^ . "Kenneth Offit"^^ . . "Christoph"^^ . "Engel"^^ . "Christoph Engel"^^ . . "Kathleen B. M."^^ . "Claes"^^ . "Kathleen B. M. Claes"^^ . . "Lauren"^^ . "Jacobs"^^ . "Lauren Jacobs"^^ . . "Linda"^^ . "Steele"^^ . "Linda Steele"^^ . . "Piera"^^ . "Rizzolo"^^ . "Piera Rizzolo"^^ . . "Louise"^^ . "Izatt"^^ . "Louise Izatt"^^ . . "Claudine"^^ . "Isaacs"^^ . "Claudine Isaacs"^^ . . "Laura"^^ . "Spugnesi"^^ . "Laura Spugnesi"^^ . . "Esther M."^^ . "John"^^ . "Esther M. John"^^ . . "Marco"^^ . "Montagna"^^ . "Marco Montagna"^^ . . "Gero"^^ . "Kramer"^^ . "Gero Kramer"^^ . . "Timothy R."^^ . "Rebbeck"^^ . "Timothy R. Rebbeck"^^ . . "Valeria"^^ . "Pensotti"^^ . "Valeria Pensotti"^^ . . "Eric"^^ . "Hahnen"^^ . "Eric Hahnen"^^ . . "Dorothea"^^ . "Wand"^^ . "Dorothea Wand"^^ . . "Manuel R."^^ . "Teixeira"^^ . "Manuel R. Teixeira"^^ . . "Irene L."^^ . "Andrulis"^^ . "Irene L. Andrulis"^^ . . "Peter J."^^ . "Hulick"^^ . "Peter J. Hulick"^^ . . "Pedro"^^ . "Perez Segura"^^ . "Pedro Perez Segura"^^ . . "Tom"^^ . "van Maerken"^^ . "Tom van Maerken"^^ . . "Christine"^^ . "Rappaport-Fuerhauser"^^ . "Christine Rappaport-Fuerhauser"^^ . . "Siranoush"^^ . "Manoukian"^^ . "Siranoush Manoukian"^^ . . "Priyanka"^^ . "Sharma"^^ . "Priyanka Sharma"^^ . . "Angel"^^ . "Izquierdo"^^ . "Angel Izquierdo"^^ . . . . . . "Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2 (PDF)"^^ . . . "13058_2016_Article_671.pdf"^^ . . . "Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2 (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2 (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2 (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2 (Other)"^^ . . . . . . "small.jpg"^^ . . . "Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2 (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #20247 \n\nMale breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2\n\n" . "text/html" . . . "610 Medizin"@de . "610 Medical sciences Medicine"@en . .