title: Genetic predisposition to ductal carcinoma in situ of the breast
creator: Petridis, Christos
creator: Brook, Mark N.
creator: Shah, Vandna
creator: Kohut, Kelly
creator: Gorman, Patricia
creator: Caneppele, Michele
creator: Levi, Dina
creator: Papouli, Efterpi
creator: Orr, Nick
creator: Cox, Angela
creator: Cross, Simon S.
creator: dos-Santos-Silva, Isabel
creator: Peto, Julian
creator: Swerdlow, Anthony
creator: Schoemaker, Minouk J.
creator: Bolla, Manjeet K.
creator: Wang, Qin
creator: Dennis, Joe
creator: Michailidou, Kyriaki
creator: Benitez, Javier
creator: González-Neira, Anna
creator: Tessier, Daniel C.
creator: Vincent, Daniel
creator: Li, Jingmei
creator: Figueroa, Jonine
creator: Kristensen, Vessela
creator: Borresen-Dale, Anne-Lise
creator: Soucy, Penny
creator: Simard, Jacques
creator: Milne, Roger L.
creator: Giles, Graham G.
creator: Margolin, Sara
creator: Lindblom, Annika
creator: Brüning, Thomas
creator: Brauch, Hiltrud
creator: Southey, Melissa C.
creator: Hopper, John L.
creator: Dörk, Thilo
creator: Bogdanova, Natalia V.
creator: Kabisch, Maria
creator: Hamann, Ute
creator: Schmutzler, Rita K.
creator: Meindl, Alfons
creator: Brenner, Hermann
creator: Arndt, Volker
creator: Winqvist, Robert
creator: Pylkäs, Katri
creator: Fasching, Peter A.
creator: Beckmann, Matthias W.
creator: Lubinski, Jan
creator: Jakubowska, Anna
creator: Mulligan, Anna Marie
creator: Andrulis, Irene L.
creator: Tollenaar, Rob A. E. M.
creator: Devilee, Peter
creator: Le Marchand, Loic
creator: Haiman, Christopher A
creator: Mannermaa, Arto
creator: Kosma, Veli-Matti
creator: Radice, Paolo
creator: Peterlongo, Paolo
creator: Marme, Frederik
creator: Burwinkel, Barbara
creator: van Deurzen, Carolien H. M.
creator: Hollestelle, Antoinette
creator: Miller, Nicola
creator: Kerin, Michael J.
creator: Lambrechts, Diether
creator: Floris, Giuseppe
creator: Wesseling, Jelle
creator: Flyger, Henrik
creator: Bojesen, Stig E.
creator: Yao, Song
creator: Ambrosone, Christine B.
creator: Chenevix-Trench, Georgia
creator: Truong, Thérèse
creator: Guénel, Pascal
creator: Rudolph, Anja
creator: Chang-Claude, Jenny
creator: Nevanlinna, Heli
creator: Blomqvist, Carl
creator: Czene, Kamila
creator: Brand, Judith S.
creator: Olson, Janet E.
creator: Couch, Fergus J.
creator: Dunning, Alison M.
creator: Hall, Per
creator: Easton, Douglas F.
creator: Pharoah, Paul D. P.
creator: Pinder, Sarah E.
creator: Schmidt, Marjanka K.
creator: Tomlinson, Ian
creator: Roylance, Rebecca
creator: García-Closas, Montserrat
creator: Sawyer, Elinor J.
subject: ddc-610
subject: 610 Medical sciences Medicine
description: Background: Ductal carcinoma in situ (DCIS) is a non-invasive form of breast cancer. It is often associated with invasive ductal carcinoma (IDC), and is considered to be a non-obligate precursor of IDC. It is not clear to what extent these two forms of cancer share low-risk susceptibility loci, or whether there are differences in the strength of association for shared loci.   Methods: To identify genetic polymorphisms that predispose to DCIS, we pooled data from 38 studies comprising 5,067 cases of DCIS, 24,584 cases of IDC and 37,467 controls, all genotyped using the iCOGS chip.   Results: Most (67 %) of the 76 known breast cancer predisposition loci showed an association with DCIS in the same direction as previously reported for invasive breast cancer. Case-only analysis showed no evidence for differences between associations for IDC and DCIS after considering multiple testing. Analysis by estrogen receptor (ER) status confirmed that loci associated with ER positive IDC were also associated with ER positive DCIS. Analysis of DCIS by grade suggested that two independent SNPs at 11q13.3 near CCND1 were specific to low/intermediate grade DCIS (rs75915166, rs554219). These associations with grade remained after adjusting for ER status and were also found in IDC. We found no novel DCIS-specific loci at a genome wide significance level of P < 5.0x10-8.   Conclusion: In conclusion, this study provides the strongest evidence to date of a shared genetic susceptibility for IDC and DCIS. Studies with larger numbers of DCIS are needed to determine if IDC or DCIS specific loci exist.
publisher: BioMed Central
date: 2016
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/20285/1/13058_2016_Article_675.pdf
identifier: DOI:
identifier: urn:nbn:de:bsz:16-heidok-202858
identifier:   Petridis, Christos ; Brook, Mark N. ; Shah, Vandna ; Kohut, Kelly ; Gorman, Patricia ; Caneppele, Michele ; Levi, Dina ; Papouli, Efterpi ; Orr, Nick ; Cox, Angela ; Cross, Simon S. ; dos-Santos-Silva, Isabel ; Peto, Julian ; Swerdlow, Anthony ; Schoemaker, Minouk J. ; Bolla, Manjeet K. ; Wang, Qin ; Dennis, Joe ; Michailidou, Kyriaki ; Benitez, Javier ; González-Neira, Anna ; Tessier, Daniel C. ; Vincent, Daniel ; Li, Jingmei ; Figueroa, Jonine ; Kristensen, Vessela ; Borresen-Dale, Anne-Lise ; Soucy, Penny ; Simard, Jacques ; Milne, Roger L. ; Giles, Graham G. ; Margolin, Sara ; Lindblom, Annika ; Brüning, Thomas ; Brauch, Hiltrud ; Southey, Melissa C. ; Hopper, John L. ; Dörk, Thilo ; Bogdanova, Natalia V. ; Kabisch, Maria ; Hamann, Ute ; Schmutzler, Rita K. ; Meindl, Alfons ; Brenner, Hermann ; Arndt, Volker ; Winqvist, Robert ; Pylkäs, Katri ; Fasching, Peter A. ; Beckmann, Matthias W. ; Lubinski, Jan ; Jakubowska, Anna ; Mulligan, Anna Marie ; Andrulis, Irene L. ; Tollenaar, Rob A. E. M. ; Devilee, Peter ; Le Marchand, Loic ; Haiman, Christopher A ; Mannermaa, Arto ; Kosma, Veli-Matti ; Radice, Paolo ; Peterlongo, Paolo ; Marme, Frederik ; Burwinkel, Barbara ; van Deurzen, Carolien H. M. ; Hollestelle, Antoinette ; Miller, Nicola ; Kerin, Michael J. ; Lambrechts, Diether ; Floris, Giuseppe ; Wesseling, Jelle ; Flyger, Henrik ; Bojesen, Stig E. ; Yao, Song ; Ambrosone, Christine B. ; Chenevix-Trench, Georgia ; Truong, Thérèse ; Guénel, Pascal ; Rudolph, Anja ; Chang-Claude, Jenny ; Nevanlinna, Heli ; Blomqvist, Carl ; Czene, Kamila ; Brand, Judith S. ; Olson, Janet E. ; Couch, Fergus J. ; Dunning, Alison M. ; Hall, Per ; Easton, Douglas F. ; Pharoah, Paul D. P. ; Pinder, Sarah E. ; Schmidt, Marjanka K. ; Tomlinson, Ian ; Roylance, Rebecca ; García-Closas, Montserrat ; Sawyer, Elinor J.  (2016) Genetic predisposition to ductal carcinoma in situ of the breast.  Breast Cancer Research, 18 (22).  pp. 1-15.  ISSN 1465-542X     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/20285/
rights: info:eu-repo/semantics/openAccess
rights: Please see front page of the work (Sorry, Dublin Core plugin does not recognise license id)
language: eng