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primary topic: Genetic predisposition to ductal carcinoma in situ of the breast

Genetic predisposition to ductal carcinoma in situ of the breast
type: AcademicArticle
type: Article
abstract: Background: Ductal carcinoma in situ (DCIS) is a non-invasive form of breast cancer. It is often associated with invasive ductal carcinoma (IDC), and is considered to be a non-obligate precursor of IDC. It is not clear to what extent these two forms of cancer share low-risk susceptibility loci, or whether there are differences in the strength of association for shared loci. Methods: To identify genetic polymorphisms that predispose to DCIS, we pooled data from 38 studies comprising 5,067 cases of DCIS, 24,584 cases of IDC and 37,467 controls, all genotyped using the iCOGS chip. Results: Most (67 %) of the 76 known breast cancer predisposition loci showed an association with DCIS in the same direction as previously reported for invasive breast cancer. Case-only analysis showed no evidence for differences between associations for IDC and DCIS after considering multiple testing. Analysis by estrogen receptor (ER) status confirmed that loci associated with ER positive IDC were also associated with ER positive DCIS. Analysis of DCIS by grade suggested that two independent SNPs at 11q13.3 near CCND1 were specific to low/intermediate grade DCIS (rs75915166, rs554219). These associations with grade remained after adjusting for ER status and were also found in IDC. We found no novel DCIS-specific loci at a genome wide significance level of P < 5.0x10-8. Conclusion: In conclusion, this study provides the strongest evidence to date of a shared genetic susceptibility for IDC and DCIS. Studies with larger numbers of DCIS are needed to determine if IDC or DCIS specific loci exist.
date: 2016
volume: 18
issue: 22
is part of: Breast Cancer Research
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: Genetic predisposition to ductal carcinoma in situ of the breast (PDF)
has document: Genetic predisposition to ductal carcinoma in situ of the breast (Other)
subject: 610 Medizin

Genetic predisposition to ductal carcinoma in situ of the breast (PDF)
type: Document
has file: 13058_2016_Article_675.pdf
has part: 13058_2016_Article_675.pdf

BioMed Central
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Breast Cancer Research
type: Collection
issn: 1465542X

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Genetic predisposition to ductal carcinoma in situ of the breast (Other)
type: Document
is version of: Genetic predisposition to ductal carcinoma in situ of the breast (PDF)
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Genetic predisposition to ductal carcinoma in situ of the breast (Other)
type: Document
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is volatile version of: Genetic predisposition to ductal carcinoma in situ of the breast (PDF)
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Genetic predisposition to ductal carcinoma in situ of the breast (Other)
type: Document
is version of: Genetic predisposition to ductal carcinoma in situ of the breast (PDF)
is volatile version of: Genetic predisposition to ductal carcinoma in situ of the breast (PDF)
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Genetic predisposition to ductal carcinoma in situ of the breast (Other)
type: Document
is version of: Genetic predisposition to ductal carcinoma in situ of the breast (PDF)
is volatile version of: Genetic predisposition to ductal carcinoma in situ of the breast (PDF)
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Genetic predisposition to ductal carcinoma in situ of the breast (Other)
type: Document
is version of: Genetic predisposition to ductal carcinoma in situ of the breast (PDF)
is volatile version of: Genetic predisposition to ductal carcinoma in situ of the breast (PDF)
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HTML Summary of #20285 Genetic predisposition to ductal carcinoma in situ of the breast
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primary topic: Genetic predisposition to ductal carcinoma in situ of the breast

610 Medizin
type: Concept
preferred label: 610 Medical sciences Medicine @en