<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Genetic predisposition to ductal carcinoma in situ of the breast"^^ . "Background: Ductal carcinoma in situ (DCIS) is a non-invasive form of breast cancer. It is often associated with invasive ductal carcinoma (IDC), and is considered to be a non-obligate precursor of IDC. It is not clear to what extent these two forms of cancer share low-risk susceptibility loci, or whether there are differences in the strength of association for shared loci. Methods: To identify genetic polymorphisms that predispose to DCIS, we pooled data from 38 studies comprising 5,067 cases of DCIS, 24,584 cases of IDC and 37,467 controls, all genotyped using the iCOGS chip. Results: Most (67 %) of the 76 known breast cancer predisposition loci showed an association with DCIS in the same direction as previously reported for invasive breast cancer. Case-only analysis showed no evidence for differences between associations for IDC and DCIS after considering multiple testing. Analysis by estrogen receptor (ER) status confirmed that loci associated with ER positive IDC were also associated with ER positive DCIS. Analysis of DCIS by grade suggested that two independent SNPs at 11q13.3 near CCND1 were specific to low/intermediate grade DCIS (rs75915166, rs554219). These associations with grade remained after adjusting for ER status and were also found in IDC. We found no novel DCIS-specific loci at a genome wide significance level of P < 5.0x10-8. Conclusion: In conclusion, this study provides the strongest evidence to date of a shared genetic susceptibility for IDC and DCIS. Studies with larger numbers of DCIS are needed to determine if IDC or DCIS specific loci exist."^^ . "2016" . . "18" . "22" . . "BioMed Central"^^ . . . "Breast Cancer Research"^^ . . . "1465542X" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Ian"^^ . "Tomlinson"^^ . "Ian Tomlinson"^^ . . "Alison M."^^ . "Dunning"^^ . "Alison M. Dunning"^^ . . "Roger L."^^ . "Milne"^^ . "Roger L. Milne"^^ . . "Kelly"^^ . "Kohut"^^ . "Kelly Kohut"^^ . . "Matthias W."^^ . "Beckmann"^^ . "Matthias W. Beckmann"^^ . . "Dina"^^ . "Levi"^^ . "Dina Levi"^^ . . "Sarah E."^^ . "Pinder"^^ . "Sarah E. Pinder"^^ . . "Irene L."^^ . "Andrulis"^^ . "Irene L. Andrulis"^^ . . "Frederik"^^ . "Marme"^^ . "Frederik Marme"^^ . . "Melissa C."^^ . "Southey"^^ . "Melissa C. Southey"^^ . . "Antoinette"^^ . "Hollestelle"^^ . "Antoinette Hollestelle"^^ . . "Minouk J."^^ . "Schoemaker"^^ . "Minouk J. Schoemaker"^^ . . "Fergus J."^^ . "Couch"^^ . "Fergus J. Couch"^^ . . "Isabel"^^ . "dos-Santos-Silva"^^ . "Isabel dos-Santos-Silva"^^ . . "Efterpi"^^ . "Papouli"^^ . "Efterpi Papouli"^^ . . "Volker"^^ . "Arndt"^^ . "Volker Arndt"^^ . . "Julian"^^ . "Peto"^^ . "Julian Peto"^^ . . "Alfons"^^ . "Meindl"^^ . "Alfons Meindl"^^ . . "Rebecca"^^ . "Roylance"^^ . "Rebecca Roylance"^^ . . "Daniel"^^ . "Vincent"^^ . "Daniel Vincent"^^ . . "Arto"^^ . "Mannermaa"^^ . "Arto Mannermaa"^^ . . "Katri"^^ . "Pylkäs"^^ . "Katri Pylkäs"^^ . . "Carl"^^ . "Blomqvist"^^ . "Carl Blomqvist"^^ . . "Annika"^^ . "Lindblom"^^ . "Annika Lindblom"^^ . . "Janet E."^^ . "Olson"^^ . "Janet E. Olson"^^ . . "Pascal"^^ . "Guénel"^^ . "Pascal Guénel"^^ . . "Michele"^^ . "Caneppele"^^ . "Michele Caneppele"^^ . . "Rob A. E. M."^^ . "Tollenaar"^^ . "Rob A. E. M. Tollenaar"^^ . . "Daniel C."^^ . "Tessier"^^ . "Daniel C. Tessier"^^ . . "Maria"^^ . "Kabisch"^^ . "Maria Kabisch"^^ . . "Stig E."^^ . "Bojesen"^^ . "Stig E. Bojesen"^^ . . "Mark N."^^ . "Brook"^^ . "Mark N. Brook"^^ . . "Kamila"^^ . "Czene"^^ . "Kamila Czene"^^ . . "Joe"^^ . "Dennis"^^ . "Joe Dennis"^^ . . "Judith S."^^ . "Brand"^^ . "Judith S. Brand"^^ . . "Giuseppe"^^ . "Floris"^^ . "Giuseppe Floris"^^ . . "Manjeet K."^^ . "Bolla"^^ . "Manjeet K. Bolla"^^ . . "Douglas F."^^ . "Easton"^^ . "Douglas F. Easton"^^ . . "Michael J."^^ . "Kerin"^^ . "Michael J. Kerin"^^ . . "Anne-Lise"^^ . "Borresen-Dale"^^ . "Anne-Lise Borresen-Dale"^^ . . "Christine B."^^ . "Ambrosone"^^ . "Christine B. Ambrosone"^^ . . "Anna"^^ . "González-Neira"^^ . "Anna González-Neira"^^ . . "Anthony"^^ . "Swerdlow"^^ . "Anthony Swerdlow"^^ . . "Vandna"^^ . "Shah"^^ . "Vandna Shah"^^ . . "Marjanka K."^^ . "Schmidt"^^ . "Marjanka K. Schmidt"^^ . . "Christos"^^ . "Petridis"^^ . "Christos Petridis"^^ . . "Graham G."^^ . "Giles"^^ . "Graham G. Giles"^^ . . "Thomas"^^ . "Brüning"^^ . "Thomas Brüning"^^ . . "Peter"^^ . "Devilee"^^ . "Peter Devilee"^^ . . "Jonine"^^ . "Figueroa"^^ . "Jonine Figueroa"^^ . . "Jan"^^ . "Lubinski"^^ . "Jan Lubinski"^^ . . "Diether"^^ . "Lambrechts"^^ . "Diether Lambrechts"^^ . . "Vessela"^^ . "Kristensen"^^ . "Vessela Kristensen"^^ . . "Paul D. P."^^ . "Pharoah"^^ . "Paul D. P. Pharoah"^^ . . "Loic"^^ . "Le Marchand"^^ . "Loic Le Marchand"^^ . . "Hermann"^^ . "Brenner"^^ . "Hermann Brenner"^^ . . "Simon S."^^ . "Cross"^^ . "Simon S. Cross"^^ . . "Paolo"^^ . "Radice"^^ . "Paolo Radice"^^ . . "Angela"^^ . "Cox"^^ . "Angela Cox"^^ . . "Kyriaki"^^ . "Michailidou"^^ . "Kyriaki Michailidou"^^ . . "Patricia"^^ . "Gorman"^^ . "Patricia Gorman"^^ . . "Penny"^^ . "Soucy"^^ . "Penny Soucy"^^ . . "Qin"^^ . "Wang"^^ . "Qin Wang"^^ . . "Jingmei"^^ . "Li"^^ . "Jingmei Li"^^ . . "Song"^^ . "Yao"^^ . "Song Yao"^^ . . "Robert"^^ . "Winqvist"^^ . "Robert Winqvist"^^ . . "Ute"^^ . "Hamann"^^ . "Ute Hamann"^^ . . "Thilo"^^ . "Dörk"^^ . "Thilo Dörk"^^ . . "Hiltrud"^^ . "Brauch"^^ . "Hiltrud Brauch"^^ . . "Anja"^^ . "Rudolph"^^ . "Anja Rudolph"^^ . . "Paolo"^^ . "Peterlongo"^^ . "Paolo Peterlongo"^^ . . "Sara"^^ . "Margolin"^^ . "Sara Margolin"^^ . . "Nicola"^^ . "Miller"^^ . "Nicola Miller"^^ . . "Heli"^^ . "Nevanlinna"^^ . "Heli Nevanlinna"^^ . . "John L."^^ . "Hopper"^^ . "John L. Hopper"^^ . . "Elinor J."^^ . "Sawyer"^^ . "Elinor J. Sawyer"^^ . . "Anna Marie"^^ . "Mulligan"^^ . "Anna Marie Mulligan"^^ . . "Barbara"^^ . "Burwinkel"^^ . "Barbara Burwinkel"^^ . . "Jacques"^^ . "Simard"^^ . "Jacques Simard"^^ . . "Anna"^^ . "Jakubowska"^^ . "Anna Jakubowska"^^ . . "Per"^^ . "Hall"^^ . "Per Hall"^^ . . "Javier"^^ . "Benitez"^^ . "Javier Benitez"^^ . . "Thérèse"^^ . "Truong"^^ . "Thérèse Truong"^^ . . "Montserrat"^^ . "García-Closas"^^ . "Montserrat García-Closas"^^ . . "Veli-Matti"^^ . "Kosma"^^ . "Veli-Matti Kosma"^^ . . "Henrik"^^ . "Flyger"^^ . "Henrik Flyger"^^ . . "Natalia V."^^ . "Bogdanova"^^ . "Natalia V. Bogdanova"^^ . . "Carolien H. M."^^ . "van Deurzen"^^ . "Carolien H. M. van Deurzen"^^ . . "Nick"^^ . "Orr"^^ . "Nick Orr"^^ . . "Peter A."^^ . "Fasching"^^ . "Peter A. Fasching"^^ . . "Georgia"^^ . "Chenevix-Trench"^^ . "Georgia Chenevix-Trench"^^ . . "Jenny"^^ . "Chang-Claude"^^ . "Jenny Chang-Claude"^^ . . "Jelle"^^ . "Wesseling"^^ . "Jelle Wesseling"^^ . . "Christopher A"^^ . "Haiman"^^ . "Christopher A Haiman"^^ . . "Rita K."^^ . "Schmutzler"^^ . "Rita K. Schmutzler"^^ . . . . . . "Genetic predisposition to ductal carcinoma in situ of the breast (PDF)"^^ . . . "13058_2016_Article_675.pdf"^^ . . . "Genetic predisposition to ductal carcinoma in situ of the breast (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Genetic predisposition to ductal carcinoma in situ of the breast (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Genetic predisposition to ductal carcinoma in situ of the breast (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Genetic predisposition to ductal carcinoma in situ of the breast (Other)"^^ . . . . . . "small.jpg"^^ . . . "Genetic predisposition to ductal carcinoma in situ of the breast (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #20285 \n\nGenetic predisposition to ductal carcinoma in situ of the breast\n\n" . "text/html" . . . "610 Medizin"@de . "610 Medical sciences Medicine"@en . .