TY  - JOUR
SP  - 1
N2  - Background: Ductal carcinoma in situ (DCIS) is a non-invasive form of breast cancer. It is often associated with invasive ductal carcinoma (IDC), and is considered to be a non-obligate precursor of IDC. It is not clear to what extent these two forms of cancer share low-risk susceptibility loci, or whether there are differences in the strength of association for shared loci.   Methods: To identify genetic polymorphisms that predispose to DCIS, we pooled data from 38 studies comprising 5,067 cases of DCIS, 24,584 cases of IDC and 37,467 controls, all genotyped using the iCOGS chip.   Results: Most (67 %) of the 76 known breast cancer predisposition loci showed an association with DCIS in the same direction as previously reported for invasive breast cancer. Case-only analysis showed no evidence for differences between associations for IDC and DCIS after considering multiple testing. Analysis by estrogen receptor (ER) status confirmed that loci associated with ER positive IDC were also associated with ER positive DCIS. Analysis of DCIS by grade suggested that two independent SNPs at 11q13.3 near CCND1 were specific to low/intermediate grade DCIS (rs75915166, rs554219). These associations with grade remained after adjusting for ER status and were also found in IDC. We found no novel DCIS-specific loci at a genome wide significance level of P?<?5.0x10-8.   Conclusion: In conclusion, this study provides the strongest evidence to date of a shared genetic susceptibility for IDC and DCIS. Studies with larger numbers of DCIS are needed to determine if IDC or DCIS specific loci exist.
Y1  - 2016///
TI  - Genetic predisposition to ductal carcinoma in situ of the breast
AV  - public
SN  - 1465-542X
VL  - 18
JF  - Breast Cancer Research
ID  - heidok20285
IS  - 22
CY  - London
UR  - https://archiv.ub.uni-heidelberg.de/volltextserver/20285/
A1  - Petridis, Christos
A1  - Brook, Mark N.
A1  - Shah, Vandna
A1  - Kohut, Kelly
A1  - Gorman, Patricia
A1  - Caneppele, Michele
A1  - Levi, Dina
A1  - Papouli, Efterpi
A1  - Orr, Nick
A1  - Cox, Angela
A1  - Cross, Simon S.
A1  - dos-Santos-Silva, Isabel
A1  - Peto, Julian
A1  - Swerdlow, Anthony
A1  - Schoemaker, Minouk J.
A1  - Bolla, Manjeet K.
A1  - Wang, Qin
A1  - Dennis, Joe
A1  - Michailidou, Kyriaki
A1  - Benitez, Javier
A1  - González-Neira, Anna
A1  - Tessier, Daniel C.
A1  - Vincent, Daniel
A1  - Li, Jingmei
A1  - Figueroa, Jonine
A1  - Kristensen, Vessela
A1  - Borresen-Dale, Anne-Lise
A1  - Soucy, Penny
A1  - Simard, Jacques
A1  - Milne, Roger L.
A1  - Giles, Graham G.
A1  - Margolin, Sara
A1  - Lindblom, Annika
A1  - Brüning, Thomas
A1  - Brauch, Hiltrud
A1  - Southey, Melissa C.
A1  - Hopper, John L.
A1  - Dörk, Thilo
A1  - Bogdanova, Natalia V.
A1  - Kabisch, Maria
A1  - Hamann, Ute
A1  - Schmutzler, Rita K.
A1  - Meindl, Alfons
A1  - Brenner, Hermann
A1  - Arndt, Volker
A1  - Winqvist, Robert
A1  - Pylkäs, Katri
A1  - Fasching, Peter A.
A1  - Beckmann, Matthias W.
A1  - Lubinski, Jan
A1  - Jakubowska, Anna
A1  - Mulligan, Anna Marie
A1  - Andrulis, Irene L.
A1  - Tollenaar, Rob A. E. M.
A1  - Devilee, Peter
A1  - Le Marchand, Loic
A1  - Haiman, Christopher A
A1  - Mannermaa, Arto
A1  - Kosma, Veli-Matti
A1  - Radice, Paolo
A1  - Peterlongo, Paolo
A1  - Marme, Frederik
A1  - Burwinkel, Barbara
A1  - van Deurzen, Carolien H. M.
A1  - Hollestelle, Antoinette
A1  - Miller, Nicola
A1  - Kerin, Michael J.
A1  - Lambrechts, Diether
A1  - Floris, Giuseppe
A1  - Wesseling, Jelle
A1  - Flyger, Henrik
A1  - Bojesen, Stig E.
A1  - Yao, Song
A1  - Ambrosone, Christine B.
A1  - Chenevix-Trench, Georgia
A1  - Truong, Thérèse
A1  - Guénel, Pascal
A1  - Rudolph, Anja
A1  - Chang-Claude, Jenny
A1  - Nevanlinna, Heli
A1  - Blomqvist, Carl
A1  - Czene, Kamila
A1  - Brand, Judith S.
A1  - Olson, Janet E.
A1  - Couch, Fergus J.
A1  - Dunning, Alison M.
A1  - Hall, Per
A1  - Easton, Douglas F.
A1  - Pharoah, Paul D. P.
A1  - Pinder, Sarah E.
A1  - Schmidt, Marjanka K.
A1  - Tomlinson, Ian
A1  - Roylance, Rebecca
A1  - García-Closas, Montserrat
A1  - Sawyer, Elinor J.
PB  - BioMed Central
EP  - 15
ER  -