<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "Coronin regulates motility in malaria parasites"^^ . "Coronins are actin-binding proteins that regulate many cellular processes including cell migration in a diverse range of cells from Dictyostelium to neurons. Malaria parasites need to migrate in order to penetrate tissue barriers and enter host cells. Here I show that Plasmodium\r\nberghei coronin is an important regulator of gliding motility in sporozoites, the highly motile life cycle forms of the parasite that are transmitted by mosquitoes to the rodent host. Using in situ tagging coronin was found to localize to the periphery of sporozoites, where an actin-myosin motor propels the parasite. During sporozoite activation through external ligands, which triggers intracellular calcium release and coronin binding to actin, coronin relocalizes to the rear end of the parasite; there cAMP-protein kinase A pathway is essential for depolymerization of F-actin. I suggest that calcium and cAMP mediated signaling are linked such that calcium dominated signaling operates during motility, while cAMP dominated signaling operates during the hepatocyte invasion. Ablation of the actin binding sites of endogenous coronin leads to defects in sporozoite motility similar to coronin(-). However, unlike coronin(-), which develops smaller liver stages, the actin-binding mutants do not exhibit this liver stage developmental defect suggesting an actin-independent function of coronin. Motility and developmental defects exhibited by coronin(-) are partially complemented by Pf-coronin which displays 57% identity with the P. berghei protein and has experimentally been shown to bundle actin filaments. Finally, the overexpression of coronin is not deleterious to growth and development of P. berghei, unlike the overexpression defect exhibited by yeast coronin. This benefits the study of ookinete motility as the overexpression of fluorescent coronin aids in probing the presence of actin filaments."^^ . "2016" . . . . . . . "Kartik"^^ . "Bane"^^ . "Kartik Bane"^^ . . . . . . "Coronin regulates motility in malaria parasites (PDF)"^^ . . . "Kartik Bane.pdf"^^ . . . "Coronin regulates motility in malaria parasites (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Coronin regulates motility in malaria parasites (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Coronin regulates motility in malaria parasites (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Coronin regulates motility in malaria parasites (Other)"^^ . . . . . . "small.jpg"^^ . . . "Coronin regulates motility in malaria parasites (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #20355 \n\nCoronin regulates motility in malaria parasites\n\n" . "text/html" . . . "570 Biowissenschaften, Biologie"@de . "570 Life sciences"@en . .