title: Overall survival after reirradiation of spinal metastases – independent validation of predictive models
creator: Bürgy, Daniel
creator: Siedlitzki, Lena
creator: Boda-Heggemann, Judit
creator: Wenz, Frederik
creator: Lohr, Frank
subject: ddc-610
subject: 610 Medical sciences Medicine
description: Background: It is unknown if survival prediction tools (SPTs) sufficiently predict survival in patients who undergo palliative reirradiation of spinal metastases. We therefore set out to clarify if SPTs can predict survival in this patient population.   Methods: We retrospectively analyzed spinal reirradiations performed (n = 58, 52 patients, 44 included in analysis). SPTs for patients with spinal metastases were identified and compared to a general palliative score and to a dedicated SPT to estimate prognosis in palliative reirradiation independent of site (SPT-Nieder).   Results: Consistently in all tests, SPT-Nieder showed best predictive performance as compared to other tools. Items associated with survival were general condition (KPS), liver metastases, and steroid use. Other factors like primary tumor site, pleural effusion, and bone metastases were not correlated with survival. We adapted an own score to the data which performed comparable to SPT-Nieder but avoids the pleural effusion item. Both scores showed good performance in identifying long-term survivors with late recurrences.   Conclusions: Survival prediction in case of spinal reirradiation is possible with sufficient predictive separation. Applying SPTs in case of reirradiation helps to identify patients with good life expectancy who might benefit from dose escalation or longer treatment courses.
publisher: BioMed Central
date: 2016
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/20384/1/13014_2016_Article_613.pdf
identifier: DOI:
identifier: urn:nbn:de:bsz:16-heidok-203846
identifier:   Bürgy, Daniel ; Siedlitzki, Lena ; Boda-Heggemann, Judit ; Wenz, Frederik ; Lohr, Frank  (2016) Overall survival after reirradiation of spinal metastases – independent validation of predictive models.  Radiation Oncology, 11 (35).  pp. 1-7.  ISSN 1748-717X     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/20384/
rights: info:eu-repo/semantics/openAccess
rights: Please see front page of the work (Sorry, Dublin Core plugin does not recognise license id)
language: eng