eprintid: 20384
rev_number: 11
eprint_status: archive
userid: 1589
dir: disk0/00/02/03/84
datestamp: 2016-03-09 08:24:58
lastmod: 2024-02-01 05:55:08
status_changed: 2016-03-09 08:24:58
type: article
metadata_visibility: show
creators_name: Bürgy, Daniel
creators_name: Siedlitzki, Lena
creators_name: Boda-Heggemann, Judit
creators_name: Wenz, Frederik
creators_name: Lohr, Frank
title: Overall survival after reirradiation of spinal metastases – independent validation of predictive models
subjects: ddc-610
divisions: i-63500
abstract: Background: It is unknown if survival prediction tools (SPTs) sufficiently predict survival in patients who undergo palliative reirradiation of spinal metastases. We therefore set out to clarify if SPTs can predict survival in this patient population.   Methods: We retrospectively analyzed spinal reirradiations performed (n = 58, 52 patients, 44 included in analysis). SPTs for patients with spinal metastases were identified and compared to a general palliative score and to a dedicated SPT to estimate prognosis in palliative reirradiation independent of site (SPT-Nieder).   Results: Consistently in all tests, SPT-Nieder showed best predictive performance as compared to other tools. Items associated with survival were general condition (KPS), liver metastases, and steroid use. Other factors like primary tumor site, pleural effusion, and bone metastases were not correlated with survival. We adapted an own score to the data which performed comparable to SPT-Nieder but avoids the pleural effusion item. Both scores showed good performance in identifying long-term survivors with late recurrences.   Conclusions: Survival prediction in case of spinal reirradiation is possible with sufficient predictive separation. Applying SPTs in case of reirradiation helps to identify patients with good life expectancy who might benefit from dose escalation or longer treatment courses.
date: 2016
publisher: BioMed Central
id_scheme: DOI
ppn_swb: 1656443856
own_urn: urn:nbn:de:bsz:16-heidok-203846
language: eng
bibsort: BURGYDANIEOVERALLSUR2016
full_text_status: public
publication: Radiation Oncology
volume: 11
number: 35
place_of_pub: London
pagerange: 1-7
issn: 1748-717X
citation:   Bürgy, Daniel ; Siedlitzki, Lena ; Boda-Heggemann, Judit ; Wenz, Frederik ; Lohr, Frank  (2016) Overall survival after reirradiation of spinal metastases – independent validation of predictive models.  Radiation Oncology, 11 (35).  pp. 1-7.  ISSN 1748-717X     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/20384/1/13014_2016_Article_613.pdf