eprintid: 20465
rev_number: 16
eprint_status: archive
userid: 1589
dir: disk0/00/02/04/65
datestamp: 2016-03-17 09:40:45
lastmod: 2024-03-10 20:27:38
status_changed: 2016-03-17 09:40:45
type: article
metadata_visibility: show
creators_name: Rief, Harald
creators_name: Omlor, Georg
creators_name: Akbar, Michael
creators_name: Bruckner, Thomas
creators_name: Rieken, Stefan
creators_name: Förster, Robert
creators_name: Schlampp, Ingmar
creators_name: Welzel, Thomas
creators_name: Bostel, Tilman
creators_name: Roth, Heinz Jürgen
creators_name: Debus, Jürgen
title: Biochemical markers of bone turnover in patients with spinal metastases after resistance training under radiotherapy – a randomized trial
subjects: ddc-610
divisions: i-911460
divisions: i-911400
divisions: i-911800
abstract: Background: To compare the effects of resistance training versus passive physical therapy on bone turnover markers (BTM) in the metastatic bone during radiation therapy (RT) in patients with spinal bone metastases. Secondly, to evaluate an association of BTM to local response, skeletal-related events (SRE), and number of metastases.   Methods: In this randomized trial, 60 patients were allocated from September 2011 to March 2013 into one of the two arms: resistance training (Arm A) or passive physical therapy (Arm B) with thirty patients in each arm during RT. Biochemical markers such as pyridinoline (PYD), desoxy-pyridinoline (DPD), bone alkaline phosphatase (BAP), total amino-terminal propeptide of type I collagen (PINP), beta-isomer of carboxy-terminal telopeptide of type I collagen (CTX-I), and cross-linked N-telopeptide of type I collagen (NTX) were analyzed at baseline, and three months after RT.   Results: Mean change values of PYD and CTX-I were significantly lower at 3 months after RT (p = 0.035 and p = 0.043) in Arm A. Importantly, all markers decreased in both arms, except of PYD and CTX-I in arm B, although significance was not reached for some biomarkers. In arm A, the local response was significantly higher (p = 0.003) and PINP could be identified as a predictor for survivors (OR 0.968, 95%CI 0.938–0.999, p = 0.043). BAP (OR 0.974, 95%CI 0.950–0.998, p = 0.034) and PINP (OR 1.025, 95%CI 1.001–1.049, p = 0.044) were related with an avoidance of SRE.   Conclusions: In this group of patients with spinal bone metastases, we were able to show that patients with guided resistance training of the paravertebral muscles can influence BTM. PYD and CTX-I decreased significantly in arm A. PINP can be considered as a complementary tool for prediction of local response, and PINP as well as BAP for avoidance of SRE.   Trial registration: Clinical trial identifier NCT 01409720. August 2, 2011.
date: 2016
publisher: BioMed Central; Springer
id_scheme: DOI
ppn_swb: 1657236641
own_urn: urn:nbn:de:bsz:16-heidok-204658
language: eng
bibsort: RIEFHARALDBIOCHEMICA2016
full_text_status: public
publication: BMC Cancer
volume: 16
number: 231
place_of_pub: London; Berlin; Heidelberg
pagerange: 1-7
issn: 1471-2407
citation:   Rief, Harald ; Omlor, Georg ; Akbar, Michael ; Bruckner, Thomas ; Rieken, Stefan ; Förster, Robert ; Schlampp, Ingmar ; Welzel, Thomas ; Bostel, Tilman ; Roth, Heinz Jürgen ; Debus, Jürgen  (2016) Biochemical markers of bone turnover in patients with spinal metastases after resistance training under radiotherapy – a randomized trial.  BMC Cancer, 16 (231).  pp. 1-7.  ISSN 1471-2407     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/20465/1/12885_2016_Article_2278.pdf