eprintid: 20477
rev_number: 13
eprint_status: archive
userid: 1589
dir: disk0/00/02/04/77
datestamp: 2016-04-07 09:01:49
lastmod: 2024-04-26 21:12:27
status_changed: 2016-04-07 09:01:49
type: article
metadata_visibility: show
creators_name: Rief, Harald
creators_name: Heinhold, Rita C.
creators_name: Petersen, Lina C.
creators_name: Rieken, Stefan
creators_name: Bruckner, Thomas
creators_name: Moghaddam-Alvandi, Arash
creators_name: Debus, Jürgen
creators_name: Sterzing, Florian
title: Neurological outcome after emergency radiotherapy in MSCC of patients with non-small cell lung cancer - a prospective trial
subjects: ddc-610
divisions: i-911460
divisions: i-911400
divisions: i-911800
abstract: Background: The aim of this trial was to investigate neurological outcome after emergency RT in MSCC of NSCLC patients with acute neurological deficit.   Methods This pilot trial was prospective, non-randomized, and monocentre, ten patients were treated from July 2012 until June 2013. After onset of neurological symptoms RT was started within 12 hours. The neurological outcome was assessed at baseline, and six weeks after RT using the ASIA Impairment Scale (AIS).   Results: The results showed an improved neurological outcome in one patient (10%), one patient (10%) had a decreased, and five patients (50%) a constant outcome after six weeks. Three patients (30%) died within the first six weeks following RT, additional 4 patients (40%) died within 4 month due to tumor progression.   Conclusion: In this group of NSCLC patients we were able to show that emergency RT in MSCC with acute neurological deficit had no considerable benefit in neurological outcome. Therefore, short-course regime or best supportive care due to poor survival should be considered for these patients with additional distant metastases. Patients with favorable prognosis may be candidates for long-course RT.   Trial Registration: Clinical trial identifier http://www.clinicaltrials.gov/
date: 2013
publisher: BioMed Central
id_scheme: DOI
ppn_swb: 1656511266
own_urn: urn:nbn:de:bsz:16-heidok-204773
language: eng
bibsort: RIEFHARALDNEUROLOGIC2013
full_text_status: public
publication: Radiation Oncology
volume: 8
number: 297
place_of_pub: London
pagerange: 1-5
issn: 1748-717X
citation:   Rief, Harald ; Heinhold, Rita C. ; Petersen, Lina C. ; Rieken, Stefan ; Bruckner, Thomas ; Moghaddam-Alvandi, Arash ; Debus, Jürgen ; Sterzing, Florian  (2013) Neurological outcome after emergency radiotherapy in MSCC of patients with non-small cell lung cancer - a prospective trial.  Radiation Oncology, 8 (297).  pp. 1-5.  ISSN 1748-717X     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/20477/1/13014_2013_Article_1241.pdf