eprintid: 20478
rev_number: 11
eprint_status: archive
userid: 1589
dir: disk0/00/02/04/78
datestamp: 2016-04-07 09:04:49
lastmod: 2024-04-16 08:41:57
status_changed: 2016-04-07 09:04:49
type: article
metadata_visibility: show
creators_name: Clausznitzer, Diana
creators_name: Endres, Robert G.
title: Noise characteristics of the Escherichia colirotary motor
subjects: ddc-570
divisions: i-716000
abstract: Background: The chemotaxis pathway in the bacterium Escherichia coli allows cells to detect changes in external ligand concentration (e.g. nutrients). The pathway regulates the flagellated rotary motors and hence the cells' swimming behaviour, steering them towards more favourable environments. While the molecular components are well characterised, the motor behaviour measured by tethered cell experiments has been difficult to interpret.   Results: We study the effects of sensing and signalling noise on the motor behaviour. Specifically, we consider fluctuations stemming from ligand concentration, receptor switching between their signalling states, adaptation, modification of proteins by phosphorylation, and motor switching between its two rotational states. We develop a model which includes all signalling steps in the pathway, and discuss a simplified version, which captures the essential features of the full model. We find that the noise characteristics of the motor contain signatures from all these processes, albeit with varying magnitudes.   Conclusions: Our analysis allows us to address how cell-to-cell variation affects motor behaviour and the question of optimal pathway design. A similar comprehensive analysis can be applied to other two-component signalling pathways.
date: 2011
publisher: BioMed Central
id_scheme: DOI
ppn_swb: 1656513846
own_urn: urn:nbn:de:bsz:16-heidok-204789
language: eng
bibsort: CLAUSZNITZNOISECHARA2011
full_text_status: public
publication: BMC Systems Biology
volume: 5
number: 151
place_of_pub: London
pagerange: 1-23
issn: 1752-0509
citation:   Clausznitzer, Diana ; Endres, Robert G.  (2011) Noise characteristics of the Escherichia colirotary motor.  BMC Systems Biology, 5 (151).  pp. 1-23.  ISSN 1752-0509     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/20478/1/12918_2011_Article_763.pdf