eprintid: 20563
rev_number: 16
eprint_status: archive
userid: 1589
dir: disk0/00/02/05/63
datestamp: 2016-04-25 13:20:33
lastmod: 2024-08-10 03:19:37
status_changed: 2016-04-25 13:20:33
type: article
metadata_visibility: show
creators_name: Mundiyanapurath, Sibu
creators_name: Ringleb, Peter Arthur
creators_name: Diatschuk, Sascha
creators_name: Eidel, Oliver
creators_name: Burth, Sina
creators_name: Floca, Ralf
creators_name: Möhlenbruch, Markus
creators_name: Wick, Wolfgang
creators_name: Bendszus, Martin
creators_name: Radbruch, Alexander
title: Time-dependent parameter of perfusion imaging as independent predictor of clinical outcome in symptomatic carotid artery stenosis
subjects: ddc-610
divisions: i-712000
divisions: i-850300
divisions: i-911100
divisions: i-911810
abstract: Background: Carotid artery stenosis is a frequent cause of ischemic stroke. While any degree of stenosis can cause embolic stroke, a higher degree of stenosis can also cause hemodynamic infarction. The hemodynamic effect of a stenosis can be assessed via perfusion weighted MRI (PWI). Our aim was to investigate the ability of PWI-derived parameters such as TTP (time-to-peak) and Tmax (time to the peak of the residue curve) to predict outcome in patients with unilateral acute symptomatic internal carotid artery (sICA) stenosis.   Methods: Patients with unilateral acute sICA stenosis (≥50 % according to NASCET), without intracranial stenosis or occlusion, who underwent PWI, were included. Clinical characteristics, volume of restricted diffusion, volume of prolonged TTP and Tmax were retrospectively analyzed and correlated with outcome represented by the modified Rankin Scale (mRS) score at discharge. TTP and Tmax volumes were dichotomized using a ROC curve analysis. Multivariate analysis was performed to determine which PWI-parameter was an independent predictor of outcome.   Results: Thirty-two patients were included. Degree of stenosis, volume of visually assessed TTP and volume of TTP ≥2 s did not distinguish patients with favorable (mRS 0–2) and unfavorable (mRS 3–6) outcome. In contrast, patients with unfavorable outcome had higher volumes of TTP ≥4 s (9.12 vs. 0.87 ml; p = 0.043), TTP ≥6 s (6.70 vs. 0.20 ml; p = 0.017), Tmax ≥4 s (25.27 vs. 0.00 ml; p = 0.043), Tmax ≥6 s (9.21 vs. 0.00 ml; p = 0.017), Tmax ≥8 s (6.86 vs. 0.00 ml; p = 0.011) and Tmax ≥10s (5.94 vs. 0.00 ml; p = 0.025) in univariate analysis. Multivariate logistic regression showed that NIHSS score on admission (Odds Ratio (OR) 0.466, confidence interval (CI) [0.224;0.971], p = 0.041), Tmax ≥8 s (OR 0.025, CI [0.001;0.898] p = 0.043) and TTP ≥6 s (OR 0.025, CI [0.001;0.898] p = 0.043) were independent predictors of clinical outcome.   Conclusion: As they stood out in multivariate regression and are objective and reproducible parameters, PWI-derived volumes of Tmax ≥8 s and TTP ≥6 s might be superior to degree of stenosis and visually assessed TTP maps in predicting short term patient outcome. Future studies should assess if perfusion weighted imaging might guide the selection of patients for recanalization procedures.
date: 2016
publisher: BioMed Central; Springer
id_scheme: DOI
ppn_swb: 1656486318
own_urn: urn:nbn:de:bsz:16-heidok-205634
language: eng
bibsort: MUNDIYANAPTIMEDEPEND2016
full_text_status: public
publication: BMC Neurology
volume: 16
number: 50
place_of_pub: London; Berlin; Heidelberg
pagerange: 1-9
issn: 1471-2377
citation:   Mundiyanapurath, Sibu ; Ringleb, Peter Arthur ; Diatschuk, Sascha ; Eidel, Oliver ; Burth, Sina ; Floca, Ralf ; Möhlenbruch, Markus ; Wick, Wolfgang ; Bendszus, Martin ; Radbruch, Alexander  (2016) Time-dependent parameter of perfusion imaging as independent predictor of clinical outcome in symptomatic carotid artery stenosis.  BMC Neurology, 16 (50).  pp. 1-9.  ISSN 1471-2377     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/20563/1/12883_2016_Article_576.pdf