<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "Hyaluronan hydrogel modified intraocular implants\r\nfor glaucoma treatment"^^ . "Glaucoma is a very prevalent eye disease with more than 60 million people affected\r\nworldwide. The only form of therapy is the artificial lowering of the intraocular pressure of\r\nthe aqueous humor, which is the main cause for the disease. This can be achieved for\r\nexample by the application of an intraocular implant to drain excess liquid. Due to a nonoptimal\r\nbiocompatibility these intraocular stents often induce inflammation and fibrosis of\r\ntheir surrounding tissue. This subsequently blocks the outflow of liquid through the\r\nimplant and results in long-term failure of the therapy.\r\nThe goal of this thesis was the development of a new type of glaucoma implant made from\r\ntitanium enhanced by hyaluronan hydrogels. The basic concept was the coating of the\r\nouter surfaces of a small tube with hydrogels made from hyaluronic acid to enhance cell\r\nadhesion for a better biocompatibility and a lower occurrence of inflammation and fibrosis.\r\nSimultaneously the interior was to be filled with hyaluronan hydrogels with slightly\r\ndifferent properties to block a clogging of the drainage path by cell growth and act as a\r\nvalve to regulate the intraocular pressure. In addition the economical and work safety\r\naspects for an industrial mass production and biomedical application of these implants\r\nwere considered.\r\nIn order to achieve this goal, a number of methods to fabricate, and tools to analyze,\r\nhydrogel-enhanced glaucoma implants have been investigated in this thesis. Reaction\r\nsequences were developed to simultaneously crosslink and immobilize hyaluronan\r\nhydrogels on glass and titanium surfaces by a combination of several established methods.\r\nIn addition, fluoresceinamine was integrated into the process to generate fluorescently\r\nlabeled hydrogels, which was an effective tool for further analysis. Also, a number of\r\nmethods were designed to observe the behavior of the hydrogel-modified implants when\r\nexposed to external pressures. It was possible, by using these methods, to verify the\r\nstability of the immobilization, with hydrogels within the tubes being able to withstand the\r\npressures encountered in the glaucomatous eye without breaking apart. Furthermore it was\r\nshown that a regulation of external liquid pressures by these hydrogel-filled tubes was\r\npossible which illustrated these implants’ potential to drain excess intraocular fluid from\r\nthe glaucomatous eye without causing hypotony. The mechanism of the pressure\r\nregulation was further explored and related to the presence of channels within the\r\nhydrogels that enabled liquid flow at certain pressure levels. Since the natural occurrence\r\nof these channels during the production process of the implants was initially random, two\r\nmethods were developed to allow their artificial and reproducible creation. This was\r\nachieved either by the use of a laser to burn channels into the hydrogels or by the\r\nimplementation of small glass fibers prior to the gel formation within the tubes.\r\nThe methods established and the results gained in this thesis provide the means to generate\r\nhydrogel-enhanced implants and illustrate their general usability in glaucoma therapy by\r\nreducing intraocular pressure. In addition the process for the implant creation was\r\nsuccessfully streamlined to allow for a cost effective, low-hazard production on an\r\nindustrial scale. Future research based on the established concept will comprise the\r\noptimization of the hydrogels’ capabilities to either improve or resist cell adhesion as\r\nnecessary. Also setups will have to be designed for a miniaturization and industrial mass\r\nfabrication of the implants."^^ . "2016" . . . . . . . "Michael"^^ . "Thaller"^^ . "Michael Thaller"^^ . . . . . . "Hyaluronan hydrogel modified intraocular implants\r\nfor glaucoma treatment (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Hyaluronan hydrogel modified intraocular implants\r\nfor glaucoma treatment (Other)"^^ . . . . . . "small.jpg"^^ . . . "Hyaluronan hydrogel modified intraocular implants\r\nfor glaucoma treatment (Other)"^^ . . . . . . "indexcodes.txt"^^ . . . "Hyaluronan hydrogel modified intraocular implants\r\nfor glaucoma treatment (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Hyaluronan hydrogel modified intraocular implants\r\nfor glaucoma treatment (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Hyaluronan hydrogel modified intraocular implants\r\nfor glaucoma treatment (PDF)"^^ . . . "Thesis_Thaller_Final Version.pdf"^^ . . "HTML Summary of #20713 \n\nHyaluronan hydrogel modified intraocular implants \nfor glaucoma treatment\n\n" . "text/html" . . . "540 Chemie"@de . "540 Chemistry and allied sciences"@en . .