…
comment: The repository administrator has not yet configured an RDF license.
primary topic: Hyaluronan hydrogel modified intraocular implants for glaucoma treatment

Hyaluronan hydrogel modified intraocular implants for glaucoma treatment
type: Article
abstract: Glaucoma is a very prevalent eye disease with more than 60 million people affected worldwide. The only form of therapy is the artificial lowering of the intraocular pressure of the aqueous humor, which is the main cause for the disease. This can be achieved for example by the application of an intraocular implant to drain excess liquid. Due to a nonoptimal biocompatibility these intraocular stents often induce inflammation and fibrosis of their surrounding tissue. This subsequently blocks the outflow of liquid through the implant and results in long-term failure of the therapy. The goal of this thesis was the development of a new type of glaucoma implant made from titanium enhanced by hyaluronan hydrogels. The basic concept was the coating of the outer surfaces of a small tube with hydrogels made from hyaluronic acid to enhance cell adhesion for a better biocompatibility and a lower occurrence of inflammation and fibrosis. Simultaneously the interior was to be filled with hyaluronan hydrogels with slightly different properties to block a clogging of the drainage path by cell growth and act as a valve to regulate the intraocular pressure. In addition the economical and work safety aspects for an industrial mass production and biomedical application of these implants were considered. In order to achieve this goal, a number of methods to fabricate, and tools to analyze, hydrogel-enhanced glaucoma implants have been investigated in this thesis. Reaction sequences were developed to simultaneously crosslink and immobilize hyaluronan hydrogels on glass and titanium surfaces by a combination of several established methods. In addition, fluoresceinamine was integrated into the process to generate fluorescently labeled hydrogels, which was an effective tool for further analysis. Also, a number of methods were designed to observe the behavior of the hydrogel-modified implants when exposed to external pressures. It was possible, by using these methods, to verify the stability o…
date: 2016
author list: authors
type: EPrint
type: DoctoralThesisEPrint
is part of: repository
has document: Hyaluronan hydrogel modified intraocular implants for glaucoma treatment (Other)
has document: Hyaluronan hydrogel modified intraocular implants for glaucoma treatment (PDF)
subject: 540 Chemie

Hyaluronan hydrogel modified intraocular implants for glaucoma treatment (PDF)
type: Document
has file: Thesis_Thaller_Final Version.pdf
has part: Thesis_Thaller_Final Version.pdf

Michael Thaller
type: Person
given name: Michael
family name: Thaller

Hyaluronan hydrogel modified intraocular implants for glaucoma treatment (Other)
type: Document
is version of: Hyaluronan hydrogel modified intraocular implants for glaucoma treatment (PDF)
is volatile version of: Hyaluronan hydrogel modified intraocular implants for glaucoma treatment (PDF)
ismedium thumbnail version of: Hyaluronan hydrogel modified intraocular implants for glaucoma treatment (PDF)
has file: medium.jpg
has part: medium.jpg

Hyaluronan hydrogel modified intraocular implants for glaucoma treatment (Other)
type: Document
is version of: Hyaluronan hydrogel modified intraocular implants for glaucoma treatment (PDF)
is volatile version of: Hyaluronan hydrogel modified intraocular implants for glaucoma treatment (PDF)
issmall thumbnail version of: Hyaluronan hydrogel modified intraocular implants for glaucoma treatment (PDF)
has file: small.jpg
has part: small.jpg

Hyaluronan hydrogel modified intraocular implants for glaucoma treatment (Other)
type: Document
is version of: Hyaluronan hydrogel modified intraocular implants for glaucoma treatment (PDF)
is volatile version of: Hyaluronan hydrogel modified intraocular implants for glaucoma treatment (PDF)
is index codes version of: Hyaluronan hydrogel modified intraocular implants for glaucoma treatment (PDF)
has file: indexcodes.txt
has part: indexcodes.txt

Hyaluronan hydrogel modified intraocular implants for glaucoma treatment (Other)
type: Document
is version of: Hyaluronan hydrogel modified intraocular implants for glaucoma treatment (PDF)
is volatile version of: Hyaluronan hydrogel modified intraocular implants for glaucoma treatment (PDF)
islightbox thumbnail version of: Hyaluronan hydrogel modified intraocular implants for glaucoma treatment (PDF)
has file: lightbox.jpg
has part: lightbox.jpg

Hyaluronan hydrogel modified intraocular implants for glaucoma treatment (Other)
type: Document
is version of: Hyaluronan hydrogel modified intraocular implants for glaucoma treatment (PDF)
is volatile version of: Hyaluronan hydrogel modified intraocular implants for glaucoma treatment (PDF)
ispreview thumbnail version of: Hyaluronan hydrogel modified intraocular implants for glaucoma treatment (PDF)
has file: preview.jpg
has part: preview.jpg

HTML Summary of #20713 Hyaluronan hydrogel modified intraocular implants for glaucoma treatment
format: text/html
primary topic: Hyaluronan hydrogel modified intraocular implants for glaucoma treatment

540 Chemie
type: Concept
preferred label: 540 Chemistry and allied sciences @en