title: Anxiety and depression disorders in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension
creator: Harzheim, Dominik
creator: Klose, Hans
creator: Pinado, Fabiola Peña
creator: Ehlken, Nicola
creator: Nagel, Christian
creator: Fischer, Christine
creator: Ghofrani, Ardeschir
creator: Rosenkranz, Stephan
creator: Seyfarth, Hans-Jürgen
creator: Halank, Michael
creator: Mayer, Eckhard
creator: Grünig, Ekkehard
creator: Guth, Stefan
subject: ddc-610
subject: 610 Medical sciences Medicine
description: Background: The objective of this prospective study was to assess the prevalence of anxiety and depression disorders and their association with quality of life (QoL), clinical parameters and survival in patients with pulmonary hypertension (PH).   Methods: We prospectively assessed 158 patients invasively diagnosed with pulmonary arterial hypertension (n = 138) and inoperable chronic thromboembolic PH (n = 20) by clinical measures including quality of life (QoL, SF-36 questionnaire), cardiopulmonary exercise testing and six minute walking distance and by questionnaires for depression (PHQ-9) and anxiety (GAD-7). According to the results of the clinical examination and the questionnaires for mental disorders (MD) patients were classified into two groups, 1) with moderate to severe MD (n = 36, 22,8%), and 2) with mild or no MD (n = 122). Patients were followed for a median of 2.7 years. Investigators of QoL, SF-36 were blinded to the clinical data.   Results: At baseline the 2 groups did not differ in their severity of PH or exercise capacity. Patients with moderate to severe MD (group 1) had a significantly lower QoL shown in all subscales of SF-36 (p < 0.002). QoL impairment significantly correlated with the severity of depression (p < 0.001) and anxiety (p < 0.05). During follow-up period 32 patients died and 3 were lost to follow-up. There was no significant difference between groups regarding survival. Only 8% of the patients with MD received psychopharmacological treatment.   Conclusion: Anxiety and depression were frequently diagnosed in our patients and significantly correlated with quality of life, but not with long term survival. Further prospective studies are needed to confirm the results.
publisher: BioMed Central
date: 2013
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/20816/1/12931_2013_Article_1590.pdf
identifier: DOI:
identifier: urn:nbn:de:bsz:16-heidok-208164
identifier:   Harzheim, Dominik ; Klose, Hans ; Pinado, Fabiola Peña ; Ehlken, Nicola ; Nagel, Christian ; Fischer, Christine ; Ghofrani, Ardeschir ; Rosenkranz, Stephan ; Seyfarth, Hans-Jürgen ; Halank, Michael ; Mayer, Eckhard ; Grünig, Ekkehard ; Guth, Stefan  (2013) Anxiety and depression disorders in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension.  Respiratory Research, 14 (104).  pp. 1-10.  ISSN 1465-993X     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/20816/
rights: info:eu-repo/semantics/openAccess
rights: Please see front page of the work (Sorry, Dublin Core plugin does not recognise license id)
language: eng