eprintid: 20816
rev_number: 12
eprint_status: archive
userid: 1589
dir: disk0/00/02/08/16
datestamp: 2016-06-09 12:45:16
lastmod: 2024-04-15 20:16:17
status_changed: 2016-06-09 12:45:16
type: article
metadata_visibility: show
creators_name: Harzheim, Dominik
creators_name: Klose, Hans
creators_name: Pinado, Fabiola Peña
creators_name: Ehlken, Nicola
creators_name: Nagel, Christian
creators_name: Fischer, Christine
creators_name: Ghofrani, Ardeschir
creators_name: Rosenkranz, Stephan
creators_name: Seyfarth, Hans-Jürgen
creators_name: Halank, Michael
creators_name: Mayer, Eckhard
creators_name: Grünig, Ekkehard
creators_name: Guth, Stefan
title: Anxiety and depression disorders in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension
subjects: ddc-610
divisions: i-911500
divisions: i-950900
abstract: Background: The objective of this prospective study was to assess the prevalence of anxiety and depression disorders and their association with quality of life (QoL), clinical parameters and survival in patients with pulmonary hypertension (PH).   Methods: We prospectively assessed 158 patients invasively diagnosed with pulmonary arterial hypertension (n = 138) and inoperable chronic thromboembolic PH (n = 20) by clinical measures including quality of life (QoL, SF-36 questionnaire), cardiopulmonary exercise testing and six minute walking distance and by questionnaires for depression (PHQ-9) and anxiety (GAD-7). According to the results of the clinical examination and the questionnaires for mental disorders (MD) patients were classified into two groups, 1) with moderate to severe MD (n = 36, 22,8%), and 2) with mild or no MD (n = 122). Patients were followed for a median of 2.7 years. Investigators of QoL, SF-36 were blinded to the clinical data.   Results: At baseline the 2 groups did not differ in their severity of PH or exercise capacity. Patients with moderate to severe MD (group 1) had a significantly lower QoL shown in all subscales of SF-36 (p < 0.002). QoL impairment significantly correlated with the severity of depression (p < 0.001) and anxiety (p < 0.05). During follow-up period 32 patients died and 3 were lost to follow-up. There was no significant difference between groups regarding survival. Only 8% of the patients with MD received psychopharmacological treatment.   Conclusion: Anxiety and depression were frequently diagnosed in our patients and significantly correlated with quality of life, but not with long term survival. Further prospective studies are needed to confirm the results.
date: 2013
publisher: BioMed Central
id_scheme: DOI
ppn_swb: 1657510778
own_urn: urn:nbn:de:bsz:16-heidok-208164
language: eng
bibsort: HARZHEIMDOANXIETYAND2013
full_text_status: public
publication: Respiratory Research
volume: 14
number: 104
place_of_pub: London
pagerange: 1-10
issn: 1465-993X
citation:   Harzheim, Dominik ; Klose, Hans ; Pinado, Fabiola Peña ; Ehlken, Nicola ; Nagel, Christian ; Fischer, Christine ; Ghofrani, Ardeschir ; Rosenkranz, Stephan ; Seyfarth, Hans-Jürgen ; Halank, Michael ; Mayer, Eckhard ; Grünig, Ekkehard ; Guth, Stefan  (2013) Anxiety and depression disorders in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension.  Respiratory Research, 14 (104).  pp. 1-10.  ISSN 1465-993X     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/20816/1/12931_2013_Article_1590.pdf