eprintid: 20888
rev_number: 12
eprint_status: archive
userid: 1589
dir: disk0/00/02/08/88
datestamp: 2016-06-16 06:58:00
lastmod: 2024-04-16 02:48:36
status_changed: 2016-06-16 06:58:00
type: article
metadata_visibility: show
creators_name: Riffel, Johannes H.
creators_name: Keller, Marius G. P.
creators_name: Rost, Franziska
creators_name: Arenja, Nisha
creators_name: Andre, Florian
creators_name: Siepen, Fabian
creators_name: Fritz, Thomas
creators_name: Ehlermann, Philipp
creators_name: Täger, Tobias
creators_name: Frankenstein, Lutz
creators_name: Meder, Benjamin
creators_name: Katus, Hugo A.
creators_name: Buss, Sebastian J.
title: Left ventricular long axis strain: a new prognosticator in non-ischemic dilated cardiomyopathy?
subjects: ddc-610
divisions: i-910100
abstract: Background: Long axis strain (LAS) has been shown to be a fast assessable parameter representing global left ventricular (LV) longitudinal function in cardiovascular magnetic resonance (CMR). However, the prognostic value of LAS in cardiomyopathies with reduced left ventricular ejection fraction (LVEF) has not been evaluated yet.   Methods and results: In 146 subjects with non-ischemic dilated cardiomyopathy (NIDCM, LVEF ≤45 %) LAS was assessed retrospectively from standard non-contrast SSFP cine sequences by measuring the distance between the epicardial border of the left ventricular apex and the midpoint of a line connecting the origins of the mitral valve leaflets in end-systole and end-diastole. The final values were calculated according to the strain formula. The primary endpoint of the study was defined as a combination of cardiac death, heart transplantation or aborted sudden cardiac death and occurred in 24 subjects during follow-up. Patients with LAS values > −5 % showed a significant higher rate of cardiac events independent of the presence of late gadolinium enhancement (LGE). The multivariate Cox regression analysis revealed that LVEDV/BSA (HR: 1.01, p < 0.05), presence of LGE (HR: 2.51, p < 0.05) and LAS (HR: 1.28, p < 0.05) were independent predictors for cardiac events. In a sequential cox regression analysis LAS offered significant incremental information (p < 0.05) for the prediction of outcome in addition to LGE and LVEDV/BSA. Using a dichotomous three point scoring model for risk stratification, including LVEF <35 %, LAS > −10 % and the presence of LGE, patients with 3 points had a significantly higher risk for cardiac events than those with 2 or less points.   Conclusion: Assessment of long axis function with LAS offers significant incremental information for the prediction of cardiac events in NIDCM and improves risk stratification beyond established CMR parameters.
date: 2016
publisher: BioMed Central
id_scheme: DOI
ppn_swb: 1653756500
own_urn: urn:nbn:de:bsz:16-heidok-208887
language: eng
bibsort: RIFFELJOHALEFTVENTRI2016
full_text_status: public
publication: Journal of Cardiovascular Magnetic Resonance
volume: 18
number: 36
place_of_pub: London
pagerange: 1-10
issn: 1532-429X
citation:   Riffel, Johannes H. ; Keller, Marius G. P. ; Rost, Franziska ; Arenja, Nisha ; Andre, Florian ; Siepen, Fabian ; Fritz, Thomas ; Ehlermann, Philipp ; Täger, Tobias ; Frankenstein, Lutz ; Meder, Benjamin ; Katus, Hugo A. ; Buss, Sebastian J.  (2016) Left ventricular long axis strain: a new prognosticator in non-ischemic dilated cardiomyopathy?  Journal of Cardiovascular Magnetic Resonance, 18 (36).  pp. 1-10.  ISSN 1532-429X     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/20888/1/12968_2016_Article_255.pdf