title: Heart transplantation as salvage therapy for progressive prosthetic valve endocarditis due to methicillin-resistant Staphylococcus epidermidis (MRSE)
creator: Borde, J. P.
creator: Sitaru, G.
creator: Kopp, W. H
creator: Ruhparwar, Arjang
creator: Ehlermann, Philipp
creator: Lasitschka, Felix
creator: Dalpke, Alexander
creator: Heininger, Alexandra
subject: ddc-610
subject: 610 Medical sciences Medicine
description: Background: Prosthetic valve endocarditis (PVE) has the highest in-hospital mortality among all cases of infective endocarditis (IE), it is estimated at about 40 %. Orthotopic heart transplantation (OHT) as a measure of last resort, may be considered in selected cases where repeated surgical procedures and conservative efforts have failed to eradicate persistent or recurrent IE. Only few clinical data are available regarding this rare indication for OHT, since active IE has traditionally been considered as a contraindication for OHT.   Case presentation: We report on a 55 year old male patient who underwent prosthetic valve replacement with a mechanical valved conduit ten years ago and developed now persistent PVE with severe complications due to methicillin-resistant Staphylococcus epidermidis (MRSE). Repeated surgical procedures and conservative efforts have failed to eradicate the pathogen. Regarding the lack of curative options, salvage OHT was discussed as a measure of last resort. 28 months after the first diagnosis of PVE, the patient was successfully transplanted and is now doing well under close follow-up (6 months post-OHT).   Conclusions: PVE remains a challenging condition regarding diagnosis and treatment. The presented case underscores the urgent need for an integrated and multidisciplinary approach to patients with suspected and definitive IE - especially in PVE. OHT might be a feasible measure of last resort in selected patients with IE. Our case report adds published clinical experience to this rarely performed procedure and consolidates previous findings.
publisher: BioMed Central
date: 2016
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/21486/1/13019_2016_Article_505.pdf
identifier: DOI:http://dx.doi.org/10.1186/s13019-016-0505-0
identifier: urn:nbn:de:bsz:16-heidok-214864
identifier:   Borde, J. P. ; Sitaru, G. ; Kopp, W. H ; Ruhparwar, Arjang ; Ehlermann, Philipp ; Lasitschka, Felix ; Dalpke, Alexander ; Heininger, Alexandra  (2016) Heart transplantation as salvage therapy for progressive prosthetic valve endocarditis due to methicillin-resistant Staphylococcus epidermidis (MRSE).  Journal of Cardiothoracic Surgery, 11 (100).  pp. 1-5.  ISSN 1749-8090     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/21486/
rights: info:eu-repo/semantics/openAccess
rights: Please see front page of the work (Sorry, Dublin Core plugin does not recognise license id)
language: eng