eprintid: 21524
rev_number: 12
eprint_status: archive
userid: 1589
dir: disk0/00/02/15/24
datestamp: 2016-07-20 12:50:09
lastmod: 2024-03-12 01:50:34
status_changed: 2016-07-20 12:50:09
type: article
metadata_visibility: show
creators_name: Rieber, Juliane
creators_name: Tonndorf-Martini, Eric
creators_name: Schramm, Oliver
creators_name: Rhein, Bernhard
creators_name: König, Laila
creators_name: Adeberg, Sebastian
creators_name: Meyerhof, Eva
creators_name: Mohr, Angela
creators_name: Kappes, Jutta
creators_name: Hoffmann, Hans
creators_name: Debus, Jürgen
creators_name: Rieken, Stefan
title: Establishing stereotactic body radiotherapy with flattening filter free techniques in the treatment of pulmonary lesions - initial experiences from a single institution
subjects: 610
divisions: 911400
divisions: 942000
abstract: Background: Stereotactic body radiotherapy (SBRT) using flattening filter free (FFF)-techniques has been increasingly applied during the last years. However, clinical studies investigating this emerging technique are still rare. Hence, we analyzed toxicity and clinical outcome of pulmonary SBRT with FFF-techniques and performed dosimetric comparison to conventional techniques using flattening filters (FF).   Materials and methods: Between 05/2014 and 06/2015, 56 consecutive patients with 61 pulmonary lesions were treated with SBRT in FFF-mode. Central lesions received 8 × 7.5 Gy delivered to the conformally enclosing 80%-isodose, while peripheral lesions were treated with 3 × 15 Gy, prescribed to the 65%-isodose. Early and late toxicity (after 6 months) as well as initial clinical outcomes were evaluated. Furthermore, [deleted] plan quality and efficiency were evaluated by analyzing conformity, beam- on and total treatment delivery times in comparison to plans with FF-dose application.   Results: Median follow-up time was 9.3 months (range 1.5–18.0 months). Early toxicity was low with only 5 patients (8.9 %) reporting CTCAE 2° or higher side-effects. Only one patient (1.8 %) was diagnosed with radiation-induced pneumonitis CTCAE 3°, while 2 (3.6 %) patients suffered from pneumonitis CTCAE 2°. After 6 months, no toxicity greater than CTCAE 2° was reported. 1-year local progression-free survival, distant progression-free survival and overall survival were 92.8 %, 78.0 %, and 94.4 %, respectively. While plan quality was similar for FFF- and FF-plans in respect to conformity (p = 0.275), median beam-on time as well as total treatment time were significantly reduced for SBRT in FFF-mode compared to FF-mode (p ≤ 0.001, p ≤ 0.001).   Conclusions: Patient treatment with SBRT using FFF-techniques is safe and provides promising clinical results with only modest toxicity at significantly increased dose delivery speed.
date: 2016
publisher: BioMed Central
id_scheme: DOI
ppn_swb: 1657863883
own_urn: urn:nbn:de:bsz:16-heidok-215244
language: eng
bibsort: RIEBERJULIESTABLISHI2016
full_text_status: public
publication: Radiation Oncology
volume: 11
number: 80
place_of_pub: London
pagerange: 1-8
issn: 1748-717X
citation:   Rieber, Juliane ; Tonndorf-Martini, Eric ; Schramm, Oliver ; Rhein, Bernhard ; König, Laila ; Adeberg, Sebastian ; Meyerhof, Eva ; Mohr, Angela ; Kappes, Jutta ; Hoffmann, Hans ; Debus, Jürgen ; Rieken, Stefan  (2016) Establishing stereotactic body radiotherapy with flattening filter free techniques in the treatment of pulmonary lesions - initial experiences from a single institution.  Radiation Oncology, 11 (80).  pp. 1-8.  ISSN 1748-717X     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/21524/1/13014_2016_Article_648.pdf