TY  - JOUR
A1  - Klupp, Fee
A1  - Neumann, Lena
A1  - Kahlert, Christoph
A1  - Diers, Johannes
A1  - Halama, Niels
A1  - Franz, Clemens
A1  - Schmidt, Thomas
A1  - Koch, Moritz
A1  - Weitz, Jürgen
A1  - Schneider, Martin
A1  - Ulrich, Alexis
PB  - BioMed Central; Springer
UR  - https://archiv.ub.uni-heidelberg.de/volltextserver/21582/
AV  - public
N2  - Background: Matrixmetalloproteinases (MMPs) comprise a family of zinc-dependent endopeptidases which are involved in angiogenesis, tumor invasion and metastatic formation. Up to date, the prognostic relevance of MMPs in serum of patients with colon cancer remains unknown. Thus, we wanted to assess an expression pattern of MMPs in a homogenous cohort of colon cancer patients to assess their potential as prognostic biomarkers.   Methods: Differences in the expression pattern of MMP7, MMP10 and MMP12 in 78 serum specimens of patients with an adenocarcinoma of the colon and serum specimens of a healthy control group were assessed using Luminex-100 technologies. Subsequently, we correlated these results with histopathological and clinical data of the patients.   Results: Luminex based expression analysis revealed a significant overexpression of MMP7 and an overexpression of MMP10 and MMP12 in the sera of colon cancer patients compared to the healthy control group. Patients with vascular invasion showed a significantly higher MMP12 expression than V0-staged patients. Moreover overexpression of MMP7, MMP10 and MMP12 in colon cancer patients´ sera displayed a significantly impaired overall survival. Multivariate analysis revealed high MMP10 serum levels to be an independent adverse prognostic marker in colon cancer patients.   Conclusions: Expression patterns of MMP7, MMP10 and MMP12 in colon cancer patients´ sera are different compared to serum specimens of healthy individuals. Furthermore, overexpression of MMP7, MMP10 and MMP12 in colon cancer patients´ sera correlates with a dismal prognosis and may help to stratify patients into different risk groups.
ID  - heidok21582
CY  - London; Berlin; Heidelberg
Y1  - 2016///
SN  - 1471-2407
EP  - 9
JF  - BMC Cancer
VL  - 16
TI  - Serum MMP7, MMP10 and MMP12 level as negative prognostic markers in colon cancer patients
IS  - 494
SP  - 1
ER  -