eprintid: 21587
rev_number: 15
eprint_status: archive
userid: 1589
dir: disk0/00/02/15/87
datestamp: 2016-07-26 08:46:48
lastmod: 2016-08-22 13:13:22
status_changed: 2016-07-26 08:46:48
type: article
metadata_visibility: show
creators_name: Esmaeilzadeh, Majid
creators_name: Dictus, Christine
creators_name: Kayvanpour, Elham
creators_name: Sedaghat-Hamedani, Farbod
creators_name: Eichbaum, Michael
creators_name: Hofer, Stefan
creators_name: Engelmann, Guido
creators_name: Fonouni, Hamidreza
creators_name: Golriz, Mohammad
creators_name: Schmidt, Jan
creators_name: Unterberg, Andreas
creators_name: Mehrabi, Arianeb
creators_name: Ahmadi, Rezvan
title: One life ends, another begins: Management of a brain-dead pregnant mother - A systematic review -
subjects: 610
divisions: 910100
divisions: 910200
divisions: 910300
divisions: 910400
divisions: 910500
divisions: 911200
abstract: Background: An accident or a catastrophic disease may occasionally lead to brain death (BD) during pregnancy. Management of brain-dead pregnant patients needs to follow special strategies to support the mother in a way that she can deliver a viable and healthy child and, whenever possible, also be an organ donor. This review discusses the management of brain-dead mothers and gives an overview of recommendations concerning the organ supporting therapy.   Methods: To obtain information on brain-dead pregnant women, we performed a systematic review of Medline, EMBASE and the Cochrane Central Register of Controlled Trials (CENTRAL). The collected data included the age of the mother, the cause of brain death, maternal medical complications, gestational age at BD, duration of extended life support, gestational age at delivery, indication of delivery, neonatal outcome, organ donation of the mothers and patient and graft outcome.   Results: In our search of the literature, we found 30 cases reported between1982 and 2010. A nontraumatic brain injury was the cause of BD in 26 of 30 mothers. The maternal mean age at the time of BD was 26.5 years. The mean gestational age at the time of BD and the mean gestational age at delivery were 22 and 29.5 weeks, respectively. Twelve viable infants were born and survived the neonatal period.   Conclusion: The management of a brain-dead pregnant woman requires a multidisciplinary team which should follow available standards, guidelines and recommendations both for a nontraumatic therapy of the fetus and for an organ-preserving treatment of the potential donor.
date: 2010
publisher: BioMed Central; Springer
id_scheme: DOI
id_number: http://dx.doi.org/10.1186/1741-7015-8-74
ppn_swb: 1658526104
own_urn: urn:nbn:de:bsz:16-heidok-215872
language: eng
bibsort: ESMAEILZADONELIFEEND2010
full_text_status: public
publication: BMC  Medicine
volume: 8
number: 74
place_of_pub: London; Berlin; Heidelberg
pagerange: 1-11
issn: 1741-7015
citation:   Esmaeilzadeh, Majid ; Dictus, Christine ; Kayvanpour, Elham ; Sedaghat-Hamedani, Farbod ; Eichbaum, Michael ; Hofer, Stefan ; Engelmann, Guido ; Fonouni, Hamidreza ; Golriz, Mohammad ; Schmidt, Jan ; Unterberg, Andreas ; Mehrabi, Arianeb ; Ahmadi, Rezvan  (2010) One life ends, another begins: Management of a brain-dead pregnant mother - A systematic review -.  BMC Medicine, 8 (74).  pp. 1-11.  ISSN 1741-7015     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/21587/1/12916_2010_Article_333.pdf