eprintid: 21655
rev_number: 15
eprint_status: archive
userid: 1589
dir: disk0/00/02/16/55
datestamp: 2016-08-17 13:16:23
lastmod: 2024-04-27 17:03:12
status_changed: 2016-08-17 13:16:23
type: article
metadata_visibility: show
creators_name: Rief, Harald
creators_name: Bruckner, Thomas
creators_name: Schlampp, Ingmar
creators_name: Bostel, Tilman
creators_name: Welzel, Thomas
creators_name: Debus, Jürgen
creators_name: Förster, Robert
title: Resistance training concomitant to radiotherapy of spinal bone metastases – survival and prognostic factors of a randomized trial
subjects: ddc-610
divisions: i-911400
divisions: i-911800
abstract: Purpose: To compare the effects of resistance training versus passive physical therapy on bone survival in the metastatic bone during radiation therapy (RT) as combined treatment in patients with spinal bone metastases. Secondly, to evaluate overall survival and progression-free-survival (PFS) as well as to quantify prognostic factors of bone survival after combined treatment.   Methods: In this randomized trial 60 patients were allocated from September 2011 until March 2013 into one of the two groups: resistance training (group A) or passive physical therapy (group B) with thirty patients in each group during RT. We estimated patient survival using Kaplan-Meier survival method. The Wald-test was used to evaluate the prognostic importance of pathological fracture, primary site, Karnofsky performance status, localization of metastases, number of metastases, and cerebral metastases.   Results: Median follow-up was 10 months (range 2–35). Bone survival showed no significant difference between groups (p = .303). Additionally no difference between groups could be detected in overall survival (p = .688) and PFS (p = .295). Local bone progression was detected in 16.7% in group B, no irradiated bone in group A showed a local progression over the course (p = 0.019). In univariate analysis breast cancer, prostate cancer, and the presence of cerebral metastases had a significant impact on bone survival in group B, while no impact could be demonstrated in group A.   Conclusions: In this group of patients with spinal bone metastases we were able to show that guided resistance training of the paravertebral muscles had no essential impact on survival concomitant to RT. Importantly, no local bone progression in group A was detected, nevertheless no prognostic factor for combined treatment could be evaluated.   Trial registration: Clinical trial identifier NCT 01409720. Registered 8 February 2011.
date: 2016
publisher: BioMed Central
id_scheme: DOI
ppn_swb: 1658533208
own_urn: urn:nbn:de:bsz:16-heidok-216555
language: eng
bibsort: RIEFHARALDRESISTANCE2016
full_text_status: public
publication: Radiation Oncology
volume: 11
number: 97
place_of_pub: London
pagerange: 1-7
issn: 1748-717X
citation:   Rief, Harald ; Bruckner, Thomas ; Schlampp, Ingmar ; Bostel, Tilman ; Welzel, Thomas ; Debus, Jürgen ; Förster, Robert  (2016) Resistance training concomitant to radiotherapy of spinal bone metastases – survival and prognostic factors of a randomized trial.  Radiation Oncology, 11 (97).  pp. 1-7.  ISSN 1748-717X     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/21655/1/13014_2016_Article_675.pdf