<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "Cross-talk between two-component systems in Escherichia coli"^^ . "Microorganisms are faced with a huge variety of environmental conditions. They use two-component signaling systems to sense and adjust their metabolism accordingly. Such two-component systems are highly abundant in genomes of bacteria, archaea and lower eukaryotes. They are comprised of a sensor histidine kinase and a response regulator which serves as a transcription factor regulating gene expression. Induction of two-component system signaling leads to autophosphorylation of the histidine kinase and the subsequent transfer of the phosphoryl-group to the response regulator. Both modularity and protein sequence similarities can give rise to signal integration between two-component systems at different levels of their signaling pathways. While cross-talk between non-cognate components of two-component systems has been assessed in vitro, not much is yet known about cross-talk in vivo. In this work, we identified in vivo interactions of two-component systems in the enterobacterium Escherichia coli using FRET microscopy. We have also characterized physiological relevant interactions of non-cognate components of the CusS/ CusR and YedV/ YedW two-component systems. In addition, our studies with promoter reporters and transcriptomic analysis showed two interconnection mechanisms, one between the histidine kinases and the non-cognate response regulators, the other on the level of induction of gene expression. Our data provide a detailed understanding of this cooperative regulation of target genes and cross-talk between the CusS/ CusR and YedV/ YedW two-component systems."^^ . "2016" . . . . . . . "Miriam"^^ . "Fischer"^^ . "Miriam Fischer"^^ . . . . . . "Cross-talk between two-component systems in Escherichia coli (PDF)"^^ . . . "Dissertation_MiriamFischer.pdf"^^ . . . "Cross-talk between two-component systems in Escherichia coli (Other)"^^ . . . . . . "indexcodes.txt"^^ . . . "Cross-talk between two-component systems in Escherichia coli (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Cross-talk between two-component systems in Escherichia coli (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Cross-talk between two-component systems in Escherichia coli (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Cross-talk between two-component systems in Escherichia coli (Other)"^^ . . . . . . "small.jpg"^^ . . "HTML Summary of #21766 \n\nCross-talk between two-component systems in Escherichia coli\n\n" . "text/html" . . . "570 Biowissenschaften, Biologie"@de . "570 Life sciences"@en . .