title: High prevalence and predominance of BRCA1 germline mutations in Pakistani triple-negative breast cancer patients
creator: Rashid, Muhammad Usman
creator: Muhammad, Noor
creator: Bajwa, Seerat
creator: Faisal, Saima
creator: Tahseen, Muhammad
creator: Lorenzo Bermejo, Justo
creator: Amin, Asim
creator: Loya, Asif
creator: Hamann, Ute
subject: 610
subject: 610 Medical sciences Medicine
description: Background: Women harboring BRCA1/2 germline mutations have high lifetime risk of developing breast/ovarian cancer. The recommendation to pursue BRCA1/2 testing is based on patient’s family history of breast/ovarian cancer, age of disease-onset and/or pathologic parameters of breast tumors. Here, we investigated if diagnosis of triple-negative breast cancer (TNBC) independently increases risk of carrying a BRCA1/2 mutation in Pakistan.   Methods: Five hundred and twenty-three breast cancer patients including 237 diagnosed ≤ 30 years of age and 286 with a family history of breast/ovarian cancer were screened for BRCA1/2 small-range mutations and large genomic rearrangements. Immunohistochemical analyses were performed at one center. Univariate and multiple logistic regression models were used to investigate possible differences in prevalence of BRCA1/2 mutations according to patient and tumor characteristics.   Results: Thirty-seven percent of patients presented with TNBC. The prevalence of BRCA1 mutations was higher in patients with TNBC than non-TNBC (37% vs. 10%, P < 0.0001). 1% of TNBC patients were observed to have BRCA2 mutations. Subgroup analyses revealed a larger proportion of BRCA1 mutations in TNBC than non-TNBC among patients 1) diagnosed at early-age with no family history of breast/ovarian cancer (14% vs. 5%, P = 0.03), 2) diagnosed at early-age irrespective of family history (28% vs. 11%, P = 0.0003), 3) had a family history of breast cancer (49% vs. 12%, P < 0.0001), and 4) those with family history of breast and ovarian cancer (81% vs. 28%, P = 0.0005). TNBC patients harboring BRCA1 mutations were diagnosed at a later age than non-carriers (median age at diagnosis: 30 years (range 22–53) vs. 28 years (range 18–67), P = 0.002). The association between TNBC status and presence of BRCA1 mutations was independent of the simultaneous consideration of family phenotype, tumor histology and grade in a multiple logistic regression model (Ratio of the probability of carrying BRCA1/2 mutations for TNBC vs. non-TNBC 4.23; 95% CI 2.50–7.14; P < 0.0001).   Conclusion: Genetic BRCA1 testing should be considered for Pakistani women diagnosed with TNBC.
publisher: BioMed Central; Springer
date: 2016
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/21808/1/12885_2016_Article_2698.pdf
identifier: DOI:
identifier: urn:nbn:de:bsz:16-heidok-218086
identifier:   Rashid, Muhammad Usman ; Muhammad, Noor ; Bajwa, Seerat ; Faisal, Saima ; Tahseen, Muhammad ; Lorenzo Bermejo, Justo ; Amin, Asim ; Loya, Asif ; Hamann, Ute  (2016) High prevalence and predominance of BRCA1 germline mutations in Pakistani triple-negative breast cancer patients.  BMC Cancer, 16 (673).  pp. 1-10.  ISSN 1471-2407     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/21808/
rights: info:eu-repo/semantics/openAccess
rights: Please see front page of the work (Sorry, Dublin Core plugin does not recognise license id)
language: eng