<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "Regulatory T cells protect the neonatal liver and secure the hepatic circadian rhythm"^^ . "Regulatory T cells (Treg cells) play a crucial role in the immune system by controlling the establishment and maintenance of immune tolerance and homeostasis. Treg cells have been described to perform additional \r\nnon-immunological functions beyond their classical functions in peripheral tissues. In this context, best examples are the specialized Treg cell population in visceral adipose tissue (VAT). The VAT-resident Treg cells gain the ability to control metabolic parameters. To further extent the concept of tissue-resident Treg cells, we aimed to analyze the phenotype and function of Treg cells in the liver tissue.\r\nWe observed a significant accumulation of hepatic Treg cells in neonatal mice at around day 10 after birth. With progressive maturation of the mice the \r\nTreg frequency normalized. The neonatal hepatic Treg cells were highly proliferative as demonstrated by cell cycle measurements. Furthermore, the cells showed the characteristic Treg cell methylation pattern of the Foxp3 locus. The Treg cell accumulation in the neonatal liver occurred in an immature liver with strongly proliferating hepatocytes, a low-grad inflammatory signature and changes in key gene expression.\r\nDepletion of Treg cells with the associated loss of Treg-mediated immune control induced major changes in the liver, including increased expression of immune-related genes and genes regulating the circadian clock such as Rev-Erb-a or Per1. The circadian expression of approximately 400 genes in the liver was affected by the ablation of Treg cells. \r\nOur results indicate that Treg cells are important to secure the circadian rhythm of genes regulating the hepatic clock as well as clock-controlled genes. Furthermore, the presence of Treg cells is required for a normal expression of genes involved in liver metabolism, especially in the neonatal phase of the mice. Therefore, we propose that Treg cells do not only control the inflammatory state of the liver, but are also critical for the establishment and maintenance of liver homeostasis."^^ . "2018" . . . . . . . "Ann-Cathrin"^^ . "Hofer"^^ . "Ann-Cathrin Hofer"^^ . . . . . . "Regulatory T cells protect the neonatal liver and secure the hepatic circadian rhythm (PDF)"^^ . . . "Dissertation Ann-Cathrin Hofer.pdf"^^ . . . "Regulatory T cells protect the neonatal liver and secure the hepatic circadian rhythm (Other)"^^ . . . . . . "indexcodes.txt"^^ . . . "Regulatory T cells protect the neonatal liver and secure the hepatic circadian rhythm (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Regulatory T cells protect the neonatal liver and secure the hepatic circadian rhythm (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Regulatory T cells protect the neonatal liver and secure the hepatic circadian rhythm (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Regulatory T cells protect the neonatal liver and secure the hepatic circadian rhythm (Other)"^^ . . . . . . "small.jpg"^^ . . "HTML Summary of #21936 \n\nRegulatory T cells protect the neonatal liver and secure the hepatic circadian rhythm\n\n" . "text/html" . . . "570 Biowissenschaften, Biologie"@de . "570 Life sciences"@en . .