<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "Genetic approaches to probe spatial coding in the medial entorhinal cortex"^^ . "The medial entorhinal cortex is a key component of the brain’s spatial navigation and memory system. It is the site where grid cells were discovered, i.e. neurons that are active at several locations in an environment, thus giving rise to a hexagonal ’grid’-like firing pattern. Experimental evidence suggests that inputs from the\r\nhippocampus, medial septum, and other brain regions, together with specific local connectivity are factors that contribute to the emergence of the grid cell pattern.\r\nTo date, it is not clear how the hippocampus, which is also involved in spatial behaviors and projects to the MEC, contributes to grid cell function. I addressed this question by recording grid cells in mice with impaired hippocampal function. My results suggest that impaired spatial hippocampal coding does not disrupt\r\ngrid cell firing. Furthermore, I gathered evidence that the MEC, as opposed to the hippocampus, is required for path integration.\r\nTo probe how specific MEC neurons support spatial behavior, we need tools to manipulate them selectively. To this end, molecular markers must be identified and assigned to functional cell types. Two promising candidates are reelin (RE) and calbindin (CB). These proteins are expressed in anatomically distinct cell types. While in vitro these neurons are distinct with respect to their electrophysio-\r\nlogical properties, it is still unclear how these differences correlate to in vivo firing patterns. I addressed this question by using two mouse lines to optogenetically tag RE + and CB + neurons. I find no major difference between the two populations, except for the pattern of projections to other brain regions. Also, I reveal the existence of a previously unknown projection from the parasubiculum to the contralateral MEC, that, along with pyramidal CB + neuron projections, appear to\r\ninhibit the contralateral MEC. These results suggest that the firing patterns of RE + and CB + cells are surprisingly similar, and that these markers may be valuable tools for studying components of cross-hemispheric connections."^^ . "2016" . . . . . . . "Oana-Daniela"^^ . "Toader"^^ . "Oana-Daniela Toader"^^ . . . . . . "Genetic approaches to probe spatial coding in the medial entorhinal cortex (PDF)"^^ . . . "thesis_main.pdf"^^ . . . "Genetic approaches to probe spatial coding in the medial entorhinal cortex (Other)"^^ . . . . . . "indexcodes.txt"^^ . . . "Genetic approaches to probe spatial coding in the medial entorhinal cortex (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Genetic approaches to probe spatial coding in the medial entorhinal cortex (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Genetic approaches to probe spatial coding in the medial entorhinal cortex (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Genetic approaches to probe spatial coding in the medial entorhinal cortex (Other)"^^ . . . . . . "small.jpg"^^ . . "HTML Summary of #22028 \n\nGenetic approaches to probe spatial coding in the medial entorhinal cortex\n\n" . "text/html" . . . "000 Allgemeines, Wissenschaft, Informatik"@de . "000 Generalities, Science"@en . . . "570 Biowissenschaften, Biologie"@de . "570 Life sciences"@en . . . "590 Tiere (Zoologie)"@de . "590 Zoological sciences"@en . . . "600 Technik, Medizin, angewandte Wissenschaften"@de . "600 Technology (Applied sciences)"@en . .