eprintid: 22041
rev_number: 22
eprint_status: archive
userid: 2788
dir: disk0/00/02/20/41
datestamp: 2016-10-28 11:21:08
lastmod: 2016-11-07 12:05:06
status_changed: 2016-10-28 11:21:08
type: doctoralThesis
metadata_visibility: show
creators_name: Degen, Christina
title: Given and acquired risk factors in cognitive decline, the development of Mild Cognitive Impairment, and Alzheimer’s Disease: results of a prospective, population-based, longitudinal study
subjects: ddc-150
divisions: i-100001
adv_faculty: af-10
cterms_swd: Demenz
cterms_swd: Leichte kognitive Beeinträchtigung
cterms_swd: Kognition
abstract: In this dissertation, three articles on the relative roles of given and acquired risk factors in cognitive aging, the development of mild cognitive impairment and Alzheimer's disease are discussed. Data are derived from the Interdisciplinary Longitudinal Study of Adult Aging (ILSE). In the first article, the role of cholesterol Levels in midlife and during aging as well as the APOE genotype are considered. In the second article, the contribution of the COMT genotype on cognitive aging is investigated. In a third article, the role of Diabetes mellitus Type II on cognitive aging is discussed. I conclude that Lifestyle factors in midlife are more important than given risk factors (e.g. genes) for risk of pathological aging.
date: 2016
id_scheme: DOI
id_number: 10.11588/heidok.00022041
ppn_swb: 1653741783
own_urn: urn:nbn:de:bsz:16-heidok-220415
date_accepted: 2016-09-13
advisor: HASH(0x55f369193000)
language: eng
bibsort: DEGENCHRISGIVENANDAC2016
full_text_status: public
place_of_pub: Heidelberg
citation:   Degen, Christina  (2016) Given and acquired risk factors in cognitive decline, the development of Mild Cognitive Impairment, and Alzheimer’s Disease: results of a prospective, population-based, longitudinal study.  [Dissertation]     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/22041/1/Dissertation_Degen.pdf