<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Spatial transcriptome analysis reveals Notch pathway-associated prognostic markers in IDH1 wild-type glioblastoma involving the subventricular zone"^^ . "Background: The spatial relationship of glioblastoma (GBM) to the subventricular zone (SVZ) is associated with inferior patient survival. However, the underlying molecular phenotype is largely unknown. We interrogated an SVZ-dependent transcriptome and potential location-specific prognostic markers. Methods: mRNA microarray data of a discovery set (n = 36 GBMs) were analyzed for SVZ-dependent gene expression and process networks using the MetaCore™ workflow. Differential gene expression was confirmed by qPCR in a validation set of 142 IDH1 wild-type GBMs that was also used for survival analysis. Results: Microarray analysis revealed a transcriptome distinctive of SVZ+ GBM that was enriched for genes associated with Notch signaling. No overlap was found to The Cancer Genome Atlas’s molecular subtypes. Independent validation of SVZ-dependent expression confirmed four genes with simultaneous prognostic impact: overexpression of HES4 (p = 0.034; HR 1.55) and DLL3 (p = 0.017; HR 1.61) predicted inferior, and overexpression of NTRK2 (p = 0.049; HR 0.66) and PIR (p = 0.025; HR 0.62) superior overall survival (OS). Additionally, overexpression of DLL3 was predictive of shorter progression-free survival (PFS) (p = 0.043; HR 1.64). Multivariate analysis revealed overexpression of HES4 to be independently associated with inferior OS (p = 0.033; HR 2.03), and overexpression of DLL3 with inferior PFS (p = 0.046; HR 1.65). Conclusions: We identified four genes with SVZ-dependent expression and prognostic significance, among those HES4 and DLL3 as part of Notch signaling, suggesting further evaluation of location-tailored targeted therapies."^^ . "2016" . . . "14" . "170" . . "BioMed Central; Springer"^^ . . . "BMC Medicine"^^ . . . "17417015" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Rolf"^^ . "Warta"^^ . "Rolf Warta"^^ . . "Niels"^^ . "Grabe"^^ . "Niels Grabe"^^ . . "Andreas"^^ . "von Deimling"^^ . "Andreas von Deimling"^^ . . "Christel"^^ . "Herold-Mende"^^ . "Christel Herold-Mende"^^ . . "Andreas"^^ . "Unterberg"^^ . "Andreas Unterberg"^^ . . "Andreas"^^ . "Mock"^^ . "Andreas Mock"^^ . . "Philipp"^^ . "Beckhove"^^ . "Philipp Beckhove"^^ . . "Bernd"^^ . "Lahrmann"^^ . "Bernd Lahrmann"^^ . . "Sara"^^ . "Friauf"^^ . "Sara Friauf"^^ . . "Christoph"^^ . "Geisenberger"^^ . "Christoph Geisenberger"^^ . . "Janina"^^ . "Exner"^^ . "Janina Exner"^^ . . "David"^^ . "Capper"^^ . "David Capper"^^ . . "Amir"^^ . "Abdollahi"^^ . "Amir Abdollahi"^^ . . "Christine"^^ . "Jungk"^^ . "Christine Jungk"^^ . . . . . . "Spatial transcriptome analysis reveals Notch pathway-associated prognostic markers in IDH1 wild-type glioblastoma involving the subventricular zone (PDF)"^^ . . . "12916_2016_Article_710.pdf"^^ . . . "Spatial transcriptome analysis reveals Notch pathway-associated prognostic markers in IDH1 wild-type glioblastoma involving the subventricular zone (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Spatial transcriptome analysis reveals Notch pathway-associated prognostic markers in IDH1 wild-type glioblastoma involving the subventricular zone (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Spatial transcriptome analysis reveals Notch pathway-associated prognostic markers in IDH1 wild-type glioblastoma involving the subventricular zone (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Spatial transcriptome analysis reveals Notch pathway-associated prognostic markers in IDH1 wild-type glioblastoma involving the subventricular zone (Other)"^^ . . . . . . "small.jpg"^^ . . . "Spatial transcriptome analysis reveals Notch pathway-associated prognostic markers in IDH1 wild-type glioblastoma involving the subventricular zone (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #22044 \n\nSpatial transcriptome analysis reveals Notch pathway-associated prognostic markers in IDH1 wild-type glioblastoma involving the subventricular zone\n\n" . "text/html" . . . "610 Medizin"@de . "610 Medical sciences Medicine"@en . .