<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 1: Frequency, syndrome specificity, influence of disease activity, long-term course, association with AQP4-IgG, and origin"^^ . "Background: Antibodies to myelin oligodendrocyte glycoprotein (MOG-IgG) have been suggested to play a role in a subset of patients with neuromyelitis optica and related disorders. Objective: To assess (i) the frequency of MOG-IgG in a large and predominantly Caucasian cohort of patients with optic neuritis (ON) and/or myelitis; (ii) the frequency of MOG-IgG among AQP4-IgG-positive patients and vice versa; (iii) the origin and frequency of MOG-IgG in the cerebrospinal fluid (CSF); (iv) the presence of MOG-IgG at disease onset; and (v) the influence of disease activity and treatment status on MOG-IgG titers. Methods: 614 serum samples from patients with ON and/or myelitis and from controls, including 92 follow-up samples from 55 subjects, and 18 CSF samples were tested for MOG-IgG using a live cell-based assay (CBA) employing full-length human MOG-transfected HEK293A cells. Results: MOG-IgG was detected in 95 sera from 50 patients with ON and/or myelitis, including 22/54 (40.7%) patients with a history of both ON and myelitis, 22/103 (21.4%) with a history of ON but no myelitis and 6/45 (13.3%) with a history of longitudinally extensive transverse myelitis but no ON, and in 1 control patient with encephalitis and a connective tissue disorder, all of whom were negative for AQP4-IgG. MOG-IgG was absent in 221 further controls, including 83 patients with AQP4-IgG-seropositive neuromyelitis optica spectrum disorders and 85 with multiple sclerosis (MS). MOG-IgG was found in 12/18 (67%) CSF samples from MOG-IgG-seropositive patients; the MOG-IgG-specific antibody index was negative in all cases, indicating a predominantly peripheral origin of CSF MOG-IgG. Serum and CSF MOG-IgG belonged to the complement-activating IgG1 subclass. MOG-IgG was present already at disease onset. The antibodies remained detectable in 40/45 (89%) follow-up samples obtained over a median period of 16.5 months (range 0–123). Serum titers were higher during attacks than during remission (p < 0.0001), highest during attacks of simultaneous myelitis and ON, lowest during acute isolated ON, and declined following treatment. Conclusions: To date, this is the largest cohort studied for IgG to human full-length MOG by means of an up-to-date CBA. MOG-IgG is present in a substantial subset of patients with ON and/or myelitis, but not in classical MS. Co-existence of MOG-IgG and AQP4-IgG is highly uncommon. CSF MOG-IgG is of extrathecal origin. Serum MOG-IgG is present already at disease onset and remains detectable in the long-term course. Serum titers depend on disease activity and treatment status."^^ . "2016" . . "13" . "279" . . "BioMed Central"^^ . . . "Journal of Neuroinflammation"^^ . . . "17422094" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Ingo"^^ . "Kleiter"^^ . "Ingo Kleiter"^^ . . "Nadja"^^ . "Borisow"^^ . "Nadja Borisow"^^ . . "Alexander"^^ . "Schwarz"^^ . "Alexander Schwarz"^^ . . "Alexander"^^ . "Winkelmann"^^ . "Alexander Winkelmann"^^ . . "Mathias"^^ . "Buttmann"^^ . "Mathias Buttmann"^^ . . "Mirjam"^^ . "Korporal-Kuhnke"^^ . "Mirjam Korporal-Kuhnke"^^ . . "Sven"^^ . "Jarius"^^ . "Sven Jarius"^^ . . "Kathrin"^^ . "Schanda"^^ . "Kathrin Schanda"^^ . . "Florence"^^ . "Pache"^^ . "Florence Pache"^^ . . "Friedemann"^^ . "Paul"^^ . "Friedemann Paul"^^ . . "Kalliopi"^^ . "Pitarokoili"^^ . "Kalliopi Pitarokoili"^^ . . "Orhan"^^ . "Aktas"^^ . "Orhan Aktas"^^ . . "Jürgen"^^ . "Haas"^^ . "Jürgen Haas"^^ . . "Brigitte"^^ . "Wildemann"^^ . "Brigitte Wildemann"^^ . . "Lena-Alexandra"^^ . "Beume"^^ . "Lena-Alexandra Beume"^^ . . "Oliver"^^ . "Stich"^^ . "Oliver Stich"^^ . . "Alexander U."^^ . "Brandt"^^ . "Alexander U. Brandt"^^ . . "Diego"^^ . "Franciotta"^^ . "Diego Franciotta"^^ . . "Kai"^^ . "Fechner"^^ . "Kai Fechner"^^ . . "Martin W."^^ . "Hümmert"^^ . "Martin W. Hümmert"^^ . . "Markus"^^ . "Reindl"^^ . "Markus Reindl"^^ . . "Klemens"^^ . "Ruprecht"^^ . "Klemens Ruprecht"^^ . . "Nasrin"^^ . "Asgari"^^ . "Nasrin Asgari"^^ . . "Marius"^^ . "Ringelstein"^^ . "Marius Ringelstein"^^ . . "Marco"^^ . "Capobianco"^^ . "Marco Capobianco"^^ . . "Hanna"^^ . "Zimmermann"^^ . "Hanna Zimmermann"^^ . . "Soeren Thue"^^ . "Lillevang"^^ . "Soeren Thue Lillevang"^^ . . "Joseph"^^ . "Kuchling"^^ . "Joseph Kuchling"^^ . . "Corinna"^^ . "Trebst"^^ . "Corinna Trebst"^^ . . . . . . "MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 1: Frequency, syndrome specificity, influence of disease activity, long-term course, association with AQP4-IgG, and origin (PDF)"^^ . . . "12974_2016_Article_717.pdf"^^ . . . "MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 1: Frequency, syndrome specificity, influence of disease activity, long-term course, association with AQP4-IgG, and origin (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 1: Frequency, syndrome specificity, influence of disease activity, long-term course, association with AQP4-IgG, and origin (Other)"^^ . . . . . . "preview.jpg"^^ . . . "MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 1: Frequency, syndrome specificity, influence of disease activity, long-term course, association with AQP4-IgG, and origin (Other)"^^ . . . . . . "medium.jpg"^^ . . . "MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 1: Frequency, syndrome specificity, influence of disease activity, long-term course, association with AQP4-IgG, and origin (Other)"^^ . . . . . . "small.jpg"^^ . . . "MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 1: Frequency, syndrome specificity, influence of disease activity, long-term course, association with AQP4-IgG, and origin (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #22059 \n\nMOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 1: Frequency, syndrome specificity, influence of disease activity, long-term course, association with AQP4-IgG, and origin\n\n" . "text/html" . . . "610 Medizin"@de . "610 Medical sciences Medicine"@en . .