eprintid: 22175
rev_number: 12
eprint_status: archive
userid: 1589
dir: disk0/00/02/21/75
datestamp: 2016-11-16 14:06:19
lastmod: 2024-03-26 05:44:12
status_changed: 2016-11-16 14:06:19
type: article
metadata_visibility: show
creators_name: Häfner, Matthias F.
creators_name: Sterzing, Florian
creators_name: Krug, David
creators_name: Körber, Stefan A.
creators_name: Jäkel, Oliver
creators_name: Debus, Jürgen
creators_name: Härtig, Martin M.
title: Intrafractional dose variation and beam configuration in carbon ion radiotherapy for esophageal cancer
subjects: 610
divisions: 850300
divisions: 911400
abstract: Background: In carbon ion radiotherapy (CIR) for esophageal cancer, organ and target motion is a major challenge for treatment planning due to potential range deviations. This study intends to analyze the impact of intrafractional variations on dosimetric parameters and to identify favourable settings for robust treatment plans.   Methods: We contoured esophageal boost volumes in different organ localizations for four patients and calculated CIR-plans with 13 different beam geometries on a free-breathing CT. Forward calculation of these plans was performed on 4D-CT datasets representing seven different phases of the breathing cycle. Plan quality was assessed for each patient and beam configuration.   Results: Target volume coverage was adequate for all settings in the baseline CIR-plans (V95 > 98% for two-beam geometries, > 94% for one-beam geometries), but reduced on 4D-CT plans (V95 range 50–95%). Sparing of the organs at risk (OAR) was adequate, but range deviations during the breathing cycle partly caused critical, maximum doses to spinal cord up to 3.5x higher than expected. There was at least one beam configuration for each patient with appropriate plan quality.   Conclusions: Despite intrafractional motion, CIR for esophageal cancer is possible with robust treatment plans when an individually optimized beam setup is selected depending on tumor size and localization.
date: 2016
publisher: BioMed Central
id_scheme: DOI
ppn_swb: 1654462047
own_urn: urn:nbn:de:bsz:16-heidok-221758
language: eng
bibsort: HAFNERMATTINTRAFRACT2016
full_text_status: public
publication: Radiation Oncology
volume: 11
number: 150
place_of_pub: London
pagerange: 1-9
issn: 1748-717X
citation:   Häfner, Matthias F. ; Sterzing, Florian ; Krug, David ; Körber, Stefan A. ; Jäkel, Oliver ; Debus, Jürgen ; Härtig, Martin M.  (2016) Intrafractional dose variation and beam configuration in carbon ion radiotherapy for esophageal cancer.  Radiation Oncology, 11 (150).  pp. 1-9.  ISSN 1748-717X     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/22175/1/13014_2016_Article_727.pdf