<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Next-generation sequencing facilitates detection of the classic E13-A20 EML4-ALK fusion in an ALK-FISH/IHC inconclusive biopsy of a stage IV lung cancer patient: a case report"^^ . "Background: Inhibition of the oncogenic fusion-gene EML4-ALK is a current first-line approach for patients with stage IV non-small cell lung cancer. While FISH was established as the gold standard for identifying these patients, there is accumulating evidence that other methods of detection, i.e., immunohistochemistry and next-generation sequencing (NGS), exist that may be equally successful. However, the concordance of these methods is under investigation. Case presentation: Adding to the current literature, we here report a 56 year old female never-smoker with stage IV lung adenocarcinoma whose biopsy was IHC and FISH inconclusive but positive in NGS. Retroactive profiling of the resection specimen corroborated fusion reads obtained by NGS, FISH-positivity and showed weak ALK-positivity by IHC. Consequently, we diagnosed the case as ALK-positive rendering the patient eligible to crizotinib treatment. Conclusions: With IHC on biopsy material only, this case would have been overlooked withholding effective therapy."^^ . "2016" . . "11" . "133" . . "BioMed Central"^^ . . . "Diagnostic Pathology"^^ . . . "17461596" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Jonas"^^ . "Leichsenring"^^ . "Jonas Leichsenring"^^ . . "Farastuk"^^ . "Bozorgmehr"^^ . "Farastuk Bozorgmehr"^^ . . "Roland"^^ . "Penzel"^^ . "Roland Penzel"^^ . . "Carlota"^^ . "Porcel"^^ . "Carlota Porcel"^^ . . "Peter"^^ . "Schirmacher"^^ . "Peter Schirmacher"^^ . . "Albrecht"^^ . "Stenzinger"^^ . "Albrecht Stenzinger"^^ . . "Anna-Lena"^^ . "Volckmar"^^ . "Anna-Lena Volckmar"^^ . . "Michael"^^ . "Thomas"^^ . "Michael Thomas"^^ . . "Arne"^^ . "Warth"^^ . "Arne Warth"^^ . . "Martina"^^ . "Kirchner"^^ . "Martina Kirchner"^^ . . "Clemens"^^ . "Lier"^^ . "Clemens Lier"^^ . . "Volker"^^ . "Endris"^^ . "Volker Endris"^^ . . . . . . "Next-generation sequencing facilitates detection of the classic E13-A20 EML4-ALK fusion in an ALK-FISH/IHC inconclusive biopsy of a stage IV lung cancer patient: a case report (PDF)"^^ . . . "13000_2016_Article_581.pdf"^^ . . . "Next-generation sequencing facilitates detection of the classic E13-A20 EML4-ALK fusion in an ALK-FISH/IHC inconclusive biopsy of a stage IV lung cancer patient: a case report (Other)"^^ . . . . . . "indexcodes.txt"^^ . . . "Next-generation sequencing facilitates detection of the classic E13-A20 EML4-ALK fusion in an ALK-FISH/IHC inconclusive biopsy of a stage IV lung cancer patient: a case report (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Next-generation sequencing facilitates detection of the classic E13-A20 EML4-ALK fusion in an ALK-FISH/IHC inconclusive biopsy of a stage IV lung cancer patient: a case report (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Next-generation sequencing facilitates detection of the classic E13-A20 EML4-ALK fusion in an ALK-FISH/IHC inconclusive biopsy of a stage IV lung cancer patient: a case report (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Next-generation sequencing facilitates detection of the classic E13-A20 EML4-ALK fusion in an ALK-FISH/IHC inconclusive biopsy of a stage IV lung cancer patient: a case report (Other)"^^ . . . . . . "small.jpg"^^ . . "HTML Summary of #22203 \n\nNext-generation sequencing facilitates detection of the classic E13-A20 EML4-ALK fusion in an ALK-FISH/IHC inconclusive biopsy of a stage IV lung cancer patient: a case report\n\n" . "text/html" . . . "610 Medizin"@de . "610 Medical sciences Medicine"@en . .