eprintid: 22239 rev_number: 13 eprint_status: archive userid: 2850 dir: disk0/00/02/22/39 datestamp: 2016-11-28 07:31:58 lastmod: 2017-01-26 12:04:38 status_changed: 2016-11-28 07:31:58 type: doctoralThesis metadata_visibility: show creators_name: Sacco, Ilaria title: Development of highly integrated PET/MR detector modules subjects: 530 subjects: 600 divisions: 130001 adv_faculty: af-13 abstract: In the last 20 years, PET imaging has become a very valuable technique for clinical diagnosis. It gives functional information on glucose metabolism and cancerous cell growth and, if coupled with precise anatomical information from MRT scans, can lead to very accurate results. The aim of the present work is the design of highly performing PET detector modules, to be used for both clinical and pre-clinical applications and compatible with operations inside MR scanner. A single-layer ceramic module, hosting both sensors and readout electronics, efficiently thermally decoupled thanks to an integrated liquid cooling channel, has been designed, fabricated and tested. Novel single-ended front-end architecture, studied for low input impedance and good timing resolution, has been designed and integrated on PETA ASIC for SiPM readout. SiPM dies for maximum light collection and identification of sub-millimeter scintillating crystals have been designed and characterized. The assembly is very compact, with an area of 32mm x 32mm, about 8mm thick without crystals, with up to 144 readout channels. It has proved excellent ToF resolution of about 230 ps CRT at FWHM for detectors in coincidence. The same module has been able to identify sub-millimeter scintillating crystals. date: 2016 id_scheme: DOI id_number: 10.11588/heidok.00022239 ppn_swb: 1655698737 own_urn: urn:nbn:de:bsz:16-heidok-222391 date_accepted: 2016-11-09 advisor: HASH(0x556120a90ed8) language: eng bibsort: SACCOILARIDEVELOPMEN2016 full_text_status: public citation: Sacco, Ilaria (2016) Development of highly integrated PET/MR detector modules. [Dissertation] document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/22239/1/main.pdf