TY  - GEN
UR  - https://archiv.ub.uni-heidelberg.de/volltextserver/22535/
ID  - heidok22535
AV  - public
KW  - Unsicherheiten
KW  -  Tomotherapy
KW  -  RapidArc
KW  -  VMAT
TI  - Uncertainties in modern radiotherapy: Tomotherapy and RapidArc
N2  - This work is dedicated to study the uncertainties occurring along the course of external
beam radiation therapy.
At first it was tested and assessed whether the quality of the detector systems used to
analyze uncertainties, as well as the rationale to decide if a plan is acceptable or not, is
sufficient. The angular dependency was investigated for the selected detector system and a
compensation method is proposed. The capability of selected TPS to create reproducible
treatment plans in clinical conditions was examined as well by applying multiple definitions
of complexity metrics.
A major part of this thesis was dedicated to introduce two new complementary software
tools to be used with TomoTherapy units. These tools allow users to identify the leading
causes for treatment failures using the built-in detector systems.
Furthermore, we illustrate how these tools can be implemented in an adaptive radiotherapy
framework by using their information to assess machine output and anatomical changes
together with their dosimetry influence on the therapy outcome of a single fraction or
cumulatively.
Such methodical studies of the occurring uncertainties and their implications contribute
substantially to the quality of treatments in radio-oncology centers.
Y1  - 2017///
A1  - Wessels, Claas
ER  -