title: Two new cases of anti-Ca (anti-ARHGAP26/GRAF) autoantibody-associated cerebellar ataxia
creator: Jarius, Sven
creator: Martínez-García, Pedro
creator: Hernandez, Adelaida León
creator: Brase, Jan Christoph
creator: Borowski, Kathrin
creator: Regula, Jens Ulrich
creator: Meinck, Hans Michael
creator: Stöcker, Winfried
creator: Wildemann, Brigitte
creator: Wandinger, Klaus-Peter
subject: ddc-610
subject: 610 Medical sciences Medicine
description: Recently, we discovered a novel serum and cerebrospinal fluid (CSF) autoantibody (anti-Ca) to Purkinje cells in a patient with autoimmune cerebellar ataxia (ACA) and identified the RhoGTPase-activating protein 26 (ARHGAP26; alternative designations include GTPase regulator associated with focal adhesion kinase pp125, GRAF, and oligophrenin-1-like protein, OPHN1L) as the target antigen. Here, we report on two new cases of ARHGAP26 autoantibody-positive ACA that were first diagnosed after publication of the index case study. While the index patient developed ACA following an episode of respiratory infection with still no evidence for malignancy 52 months after onset, neurological symptoms heralded ovarian cancer in one of the patients described here. Our finding of anti-Ca/anti-ARHGAP26 antibodies in two additional patients supports a role of autoimmunity against ARHGAP26 in the pathogenesis of ACA. Moreover, the finding of ovarian cancer in one of our patients suggests that anti-Ca/anti-ARHGAP26-positive ACA might be of paraneoplastic aetiology in some cases. In conclusion, testing for anti-Ca/anti-ARHGAP26 should be included in the diagnostic work-up of patients with ACA, and an underlying tumour should be considered in patients presenting with anti-Ca/ARHGAP26 antibody-positive ACA.
publisher: BioMed Central
date: 2013
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/22564/1/12974_2012_Article_769.pdf
identifier: DOI:
identifier: urn:nbn:de:bsz:16-heidok-225645
identifier:   Jarius, Sven ; Martínez-García, Pedro ; Hernandez, Adelaida León ; Brase, Jan Christoph ; Borowski, Kathrin ; Regula, Jens Ulrich ; Meinck, Hans Michael ; Stöcker, Winfried ; Wildemann, Brigitte ; Wandinger, Klaus-Peter  (2013) Two new cases of anti-Ca (anti-ARHGAP26/GRAF) autoantibody-associated cerebellar ataxia.  Journal of Neuroinflammation, 10 (7).  pp. 1-6.  ISSN 1742-2094     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/22564/
rights: info:eu-repo/semantics/openAccess
rights: Please see front page of the work (Sorry, Dublin Core plugin does not recognise license id)
language: eng