title: Analysis of prognostic factors in patients with newly diagnosed diffuse large B-cell lymphoma and skeletal involvement
creator: Lehners, Nicola
creator: Krämer, Isabelle
creator: Saadati, Maral
creator: Benner, Axel
creator: Ho, Anthony D.
creator: Witzens-Harig, Mathias
subject: ddc-610
subject: 610 Medical sciences Medicine
description: Background: Skeletal involvement (SI) is observed at low prevalence in patients with diffuse large B-cell lymphoma (DLBCL). Due to the rareness of this particular condition, prospective trials for these patients are scarce.   Methods: We analyzed clinical characteristics and outcome of 75 patients with DLBCL and SI in order to identify factors with prognostic impact towards progression-free survival (PFS) and overall survival (OS).   Results: Limited stage disease (Ann Arbor stage IE-IIE) was present in 34 patients (45%), 41 patients (55%) had advanced stage disease (Ann Arbor stage IIIE-IVE). Outcome was generally favorable for patients with DLBCL and SI with 3-year OS of 83%. The international prognostic index (IPI) was able to distinguish between different risk groups within this specific entity. Additionally, hypercalcemia showed to be a factor significantly associated with inferior survival. In regard to first-line treatment modalities, consolidative radiotherapy was positively associated with prolonged PFS and OS while intensification of chemotherapy had no significant impact.   Conclusions: In our cohort of patients with DLBCL and SI, high-risk IPI as well as presence of hypercalcemia were associated with inferior outcome. Consolidative radiotherapy had a positive impact on survival.
publisher: BioMed Central; Springer
date: 2017
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/22661/1/12885_2017_Article_3113.pdf
identifier: DOI:
identifier: urn:nbn:de:bsz:16-heidok-226610
identifier:   Lehners, Nicola ; Krämer, Isabelle ; Saadati, Maral ; Benner, Axel ; Ho, Anthony D. ; Witzens-Harig, Mathias  (2017) Analysis of prognostic factors in patients with newly diagnosed diffuse large B-cell lymphoma and skeletal involvement.  BMC Cancer, 17 (128).  pp. 1-7.  ISSN 1471-2407     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/22661/
rights: info:eu-repo/semantics/openAccess
rights: Please see front page of the work (Sorry, Dublin Core plugin does not recognise license id)
language: eng