<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Analysis of prognostic factors in patients with newly diagnosed diffuse large B-cell lymphoma and skeletal involvement"^^ . "Background: Skeletal involvement (SI) is observed at low prevalence in patients with diffuse large B-cell lymphoma (DLBCL). Due to the rareness of this particular condition, prospective trials for these patients are scarce. Methods: We analyzed clinical characteristics and outcome of 75 patients with DLBCL and SI in order to identify factors with prognostic impact towards progression-free survival (PFS) and overall survival (OS). Results: Limited stage disease (Ann Arbor stage IE-IIE) was present in 34 patients (45%), 41 patients (55%) had advanced stage disease (Ann Arbor stage IIIE-IVE). Outcome was generally favorable for patients with DLBCL and SI with 3-year OS of 83%. The international prognostic index (IPI) was able to distinguish between different risk groups within this specific entity. Additionally, hypercalcemia showed to be a factor significantly associated with inferior survival. In regard to first-line treatment modalities, consolidative radiotherapy was positively associated with prolonged PFS and OS while intensification of chemotherapy had no significant impact. Conclusions: In our cohort of patients with DLBCL and SI, high-risk IPI as well as presence of hypercalcemia were associated with inferior outcome. Consolidative radiotherapy had a positive impact on survival."^^ . "2017" . . "17" . "128" . . "BioMed Central; Springer"^^ . . . "BMC Cancer"^^ . . . "14712407" . . . . . . . . . . . . . . . . . . . . "Isabelle"^^ . "Krämer"^^ . "Isabelle Krämer"^^ . . "Axel"^^ . "Benner"^^ . "Axel Benner"^^ . . "Maral"^^ . "Saadati"^^ . "Maral Saadati"^^ . . "Nicola"^^ . "Lehners"^^ . "Nicola Lehners"^^ . . "Anthony D."^^ . "Ho"^^ . "Anthony D. Ho"^^ . . "Mathias"^^ . "Witzens-Harig"^^ . "Mathias Witzens-Harig"^^ . . . . . . "Analysis of prognostic factors in patients with newly diagnosed diffuse large B-cell lymphoma and skeletal involvement (PDF)"^^ . . . "12885_2017_Article_3113.pdf"^^ . . . "Analysis of prognostic factors in patients with newly diagnosed diffuse large B-cell lymphoma and skeletal involvement (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Analysis of prognostic factors in patients with newly diagnosed diffuse large B-cell lymphoma and skeletal involvement (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Analysis of prognostic factors in patients with newly diagnosed diffuse large B-cell lymphoma and skeletal involvement (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Analysis of prognostic factors in patients with newly diagnosed diffuse large B-cell lymphoma and skeletal involvement (Other)"^^ . . . . . . "small.jpg"^^ . . . "Analysis of prognostic factors in patients with newly diagnosed diffuse large B-cell lymphoma and skeletal involvement (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #22661 \n\nAnalysis of prognostic factors in patients with newly diagnosed diffuse large B-cell lymphoma and skeletal involvement\n\n" . "text/html" . . . "610 Medizin"@de . "610 Medical sciences Medicine"@en . .