TY  - JOUR
EP  - 7
PB  - BioMed Central; Springer
A1  - Lehners, Nicola
A1  - Krämer, Isabelle
A1  - Saadati, Maral
A1  - Benner, Axel
A1  - Ho, Anthony D.
A1  - Witzens-Harig, Mathias
UR  - https://archiv.ub.uni-heidelberg.de/volltextserver/22661/
CY  - London; Berlin; Heidelberg
IS  - 128
ID  - heidok22661
JF  - BMC Cancer
VL  - 17
SN  - 1471-2407
AV  - public
Y1  - 2017///
TI  - Analysis of prognostic factors in patients with newly diagnosed diffuse large B-cell lymphoma and skeletal involvement
N2  - Background: Skeletal involvement (SI) is observed at low prevalence in patients with diffuse large B-cell lymphoma (DLBCL). Due to the rareness of this particular condition, prospective trials for these patients are scarce.   Methods: We analyzed clinical characteristics and outcome of 75 patients with DLBCL and SI in order to identify factors with prognostic impact towards progression-free survival (PFS) and overall survival (OS).   Results: Limited stage disease (Ann Arbor stage IE-IIE) was present in 34 patients (45%), 41 patients (55%) had advanced stage disease (Ann Arbor stage IIIE-IVE). Outcome was generally favorable for patients with DLBCL and SI with 3-year OS of 83%. The international prognostic index (IPI) was able to distinguish between different risk groups within this specific entity. Additionally, hypercalcemia showed to be a factor significantly associated with inferior survival. In regard to first-line treatment modalities, consolidative radiotherapy was positively associated with prolonged PFS and OS while intensification of chemotherapy had no significant impact.   Conclusions: In our cohort of patients with DLBCL and SI, high-risk IPI as well as presence of hypercalcemia were associated with inferior outcome. Consolidative radiotherapy had a positive impact on survival.
SP  - 1
ER  -