eprintid: 22661
rev_number: 12
eprint_status: archive
userid: 1589
dir: disk0/00/02/26/61
datestamp: 2017-02-14 13:35:56
lastmod: 2024-03-10 23:42:08
status_changed: 2017-02-14 13:35:56
type: article
metadata_visibility: show
creators_name: Lehners, Nicola
creators_name: Krämer, Isabelle
creators_name: Saadati, Maral
creators_name: Benner, Axel
creators_name: Ho, Anthony D.
creators_name: Witzens-Harig, Mathias
title: Analysis of prognostic factors in patients with newly diagnosed diffuse large B-cell lymphoma and skeletal involvement
subjects: ddc-610
divisions: i-850300
divisions: i-910100
abstract: Background: Skeletal involvement (SI) is observed at low prevalence in patients with diffuse large B-cell lymphoma (DLBCL). Due to the rareness of this particular condition, prospective trials for these patients are scarce.   Methods: We analyzed clinical characteristics and outcome of 75 patients with DLBCL and SI in order to identify factors with prognostic impact towards progression-free survival (PFS) and overall survival (OS).   Results: Limited stage disease (Ann Arbor stage IE-IIE) was present in 34 patients (45%), 41 patients (55%) had advanced stage disease (Ann Arbor stage IIIE-IVE). Outcome was generally favorable for patients with DLBCL and SI with 3-year OS of 83%. The international prognostic index (IPI) was able to distinguish between different risk groups within this specific entity. Additionally, hypercalcemia showed to be a factor significantly associated with inferior survival. In regard to first-line treatment modalities, consolidative radiotherapy was positively associated with prolonged PFS and OS while intensification of chemotherapy had no significant impact.   Conclusions: In our cohort of patients with DLBCL and SI, high-risk IPI as well as presence of hypercalcemia were associated with inferior outcome. Consolidative radiotherapy had a positive impact on survival.
date: 2017
publisher: BioMed Central; Springer
id_scheme: DOI
ppn_swb: 1656612909
own_urn: urn:nbn:de:bsz:16-heidok-226610
language: eng
bibsort: LEHNERSNICANALYSISOF2017
full_text_status: public
publication: BMC Cancer
volume: 17
number: 128
place_of_pub: London; Berlin; Heidelberg
pagerange: 1-7
issn: 1471-2407
citation:   Lehners, Nicola ; Krämer, Isabelle ; Saadati, Maral ; Benner, Axel ; Ho, Anthony D. ; Witzens-Harig, Mathias  (2017) Analysis of prognostic factors in patients with newly diagnosed diffuse large B-cell lymphoma and skeletal involvement.  BMC Cancer, 17 (128).  pp. 1-7.  ISSN 1471-2407     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/22661/1/12885_2017_Article_3113.pdf