<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Bacopa monnieri extract increases rat coronary flow and protects against myocardial ischemia/reperfusion injury"^^ . "Background: This study explored Bacopa monnieri, a medicinal Ayurvedic herb, as a cardioprotectant against ischemia/reperfusion injury using cardiac function and coronary flow as end-points. Methods: In normal isolated rat hearts, coronary flow, left ventricular developed pressure, heart rate, and functional recovery were measured using the Langendorff preparation. Hearts were perfused with either (i) Krebs-Henseleit (normal) solution, (control), or with 30, 100 μg/ml B. monnieri ethanolic extract (30 min), or (ii) with normal solution or extract for 10 min preceding no-perfusion ischemia (30 min) followed by reperfusion (30 min) with normal solution. Infarct volumes were measured by triphenyltetrazolium staining. L-type Ca2+-currents (ICa, L) were measured by whole-cell patching in HL-1 cells, a mouse atrial cardiomyocyte cell line. Cytotoxicity of B. monnieri was assessed in rat isolated ventricular myocytes by trypan blue exclusion. Results: In normally perfused hearts, B. monnieri increased coronary flow by 63 ± 13% (30 μg/ml) and 216 ± 21% (100 μg/ml), compared to control (5 ± 3%) (n = 8–10, p < 0.001). B. monnieri treatment preceding ischemia/reperfusion improved left ventricular developed pressure by 84 ± 10% (30 μg/ml), 82 ± 10% (100 μg/ml) and 52 ± 6% (control) compared to pre- ischemia/reperfusion. Similarly, functional recovery showed a sustained increase. Moreover, B. monnieri (100 μg/ml) reduced the percentage of infarct size from 51 ± 2% (control) to 25 ± 2% (n = 6-8, p < 0.0001). B. monnieri (100 μg/ml) reduced ICa, L by 63 ± 4% in HL-1 cells. Ventricular myocyte survival decreased at higher concentrations (50–1000 μg/ml) B. monnieri. Conclusions: B. monnieri improves myocardial function following ischemia/reperfusion injury through recovery of coronary blood flow, contractile force and decrease in infarct size. Thus this may lead to a novel cardioprotectant strategy."^^ . "2017" . . "17" . "117" . . "BioMed Central"^^ . . . "BMC Complementary and Alternative Medicine"^^ . . . "14726882" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Sylvie"^^ . "Devaux"^^ . "Sylvie Devaux"^^ . . "Nina D."^^ . "Ullrich"^^ . "Nina D. Ullrich"^^ . . "Celine"^^ . "Demougeot"^^ . "Celine Demougeot"^^ . . "Krongkarn"^^ . "Chootip"^^ . "Krongkarn Chootip"^^ . . "Sarawut"^^ . "Kumphune"^^ . "Sarawut Kumphune"^^ . . "Sompol"^^ . "Tapechum"^^ . "Sompol Tapechum"^^ . . "C. Norman"^^ . "Scholfield"^^ . "C. Norman Scholfield"^^ . . "Ernst"^^ . "Niggli"^^ . "Ernst Niggli"^^ . . "Kornkanok"^^ . "Ingkaninan"^^ . "Kornkanok Ingkaninan"^^ . . "Sirintorn"^^ . "Srimachai"^^ . "Sirintorn Srimachai"^^ . . "Natakorn"^^ . "Kamkaew"^^ . "Natakorn Kamkaew"^^ . . . . . . "Bacopa monnieri extract increases rat coronary flow and protects against myocardial ischemia/reperfusion injury (PDF)"^^ . . . "12906_2017_Article_1637.pdf"^^ . . . "Bacopa monnieri extract increases rat coronary flow and protects against myocardial ischemia/reperfusion injury (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Bacopa monnieri extract increases rat coronary flow and protects against myocardial ischemia/reperfusion injury (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Bacopa monnieri extract increases rat coronary flow and protects against myocardial ischemia/reperfusion injury (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Bacopa monnieri extract increases rat coronary flow and protects against myocardial ischemia/reperfusion injury (Other)"^^ . . . . . . "small.jpg"^^ . . . "Bacopa monnieri extract increases rat coronary flow and protects against myocardial ischemia/reperfusion injury (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #22691 \n\nBacopa monnieri extract increases rat coronary flow and protects against myocardial ischemia/reperfusion injury\n\n" . "text/html" . . . "610 Medizin"@de . "610 Medical sciences Medicine"@en . .