<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Radiation-induced toxicity after image-guided and intensity-modulated radiotherapy versus external beam radiotherapy for patients with spinal bone metastases (IRON-1): a study protocol for a randomized controlled pilot trial"^^ . "Background: Radiation therapy (RT) of bone metastases provides an important treatment approach in palliative care treatment concepts. As a consequence of treatment, the extent of radiation-induced toxicity is a crucial feature with consequences to a patient’s quality of life. In this context this study aims at reducing the extent of radiation-induced side effects and toxicity by assuming a better sparing of normal tissue with the use of intensity-modulated instead of conventionally delivered external beam radiotherapy. Methods/design: In this prospective, randomized, single-center trial for patients with spinal bone metastases, RT is performed as either image-guided intensity-modulated radiotherapy (10x3Gy) or conventionally fractionated external beam radiotherapy (10x3Gy). Afterwards radiation-induced toxicity will be assessed and compared 3 and 6 months after the end of radiation. Discussion: The aim of this pilot study is the evaluation of achievable benefits, with reduced radiation toxicity being the primary endpoint in the comparison of intensity-modulated radiotherapy versus conventional radiotherapy for patients with spinal bone metastases. Secondarily, bone re-calcification, quality of life, pain relief, spinal instability, and local control will be measured and compared between the two treatment groups. Trial registration: ClinicalTrials.gov, NCT02832830. Registered on 12 July 2016."^^ . "2017" . . "18" . "98" . . "BioMed Central"^^ . . . "Trials"^^ . . . "14686694" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Tanja"^^ . "Sprave"^^ . "Tanja Sprave"^^ . . "Ingmar"^^ . "Schlampp"^^ . "Ingmar Schlampp"^^ . . "Robert"^^ . "Förster"^^ . "Robert Förster"^^ . . "Nils H."^^ . "Nicolay"^^ . "Nils H. Nicolay"^^ . . "Jürgen"^^ . "Debus"^^ . "Jürgen Debus"^^ . . "Stefan Ezechiel"^^ . "Welte"^^ . "Stefan Ezechiel Welte"^^ . . "Tilman"^^ . "Bostel"^^ . "Tilman Bostel"^^ . . "Thomas"^^ . "Bruckner"^^ . "Thomas Bruckner"^^ . . "Eva"^^ . "Meyerhof"^^ . "Eva Meyerhof"^^ . . "Harald"^^ . "Rief"^^ . "Harald Rief"^^ . . . . . . "Radiation-induced toxicity after image-guided and intensity-modulated radiotherapy versus external beam radiotherapy for patients with spinal bone metastases (IRON-1): a study protocol for a randomized controlled pilot trial (PDF)"^^ . . . "13063_2017_Article_1847.pdf"^^ . . . "Radiation-induced toxicity after image-guided and intensity-modulated radiotherapy versus external beam radiotherapy for patients with spinal bone metastases (IRON-1): a study protocol for a randomized controlled pilot trial (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Radiation-induced toxicity after image-guided and intensity-modulated radiotherapy versus external beam radiotherapy for patients with spinal bone metastases (IRON-1): a study protocol for a randomized controlled pilot trial (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Radiation-induced toxicity after image-guided and intensity-modulated radiotherapy versus external beam radiotherapy for patients with spinal bone metastases (IRON-1): a study protocol for a randomized controlled pilot trial (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Radiation-induced toxicity after image-guided and intensity-modulated radiotherapy versus external beam radiotherapy for patients with spinal bone metastases (IRON-1): a study protocol for a randomized controlled pilot trial (Other)"^^ . . . . . . "small.jpg"^^ . . . "Radiation-induced toxicity after image-guided and intensity-modulated radiotherapy versus external beam radiotherapy for patients with spinal bone metastases (IRON-1): a study protocol for a randomized controlled pilot trial (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #22707 \n\nRadiation-induced toxicity after image-guided and intensity-modulated radiotherapy versus external beam radiotherapy for patients with spinal bone metastases (IRON-1): a study protocol for a randomized controlled pilot trial\n\n" . "text/html" . . . "610 Medizin"@de . "610 Medical sciences Medicine"@en . .