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primary topic: https://archiv.ub.uni-heidelberg.de/volltextserver/id/eprint/22707

https://archiv.ub.uni-heidelberg.de/volltextserver/id/eprint/22707
type: AcademicArticle
type: Article
title: Radiation-induced toxicity after image-guided and intensity-modulated radiotherapy versus external beam radiotherapy for patients with spinal bone metastases (IRON-1): a study protocol for a randomized controlled pilot trial
abstract: Background: Radiation therapy (RT) of bone metastases provides an important treatment approach in palliative care treatment concepts. As a consequence of treatment, the extent of radiation-induced toxicity is a crucial feature with consequences to a patient’s quality of life. In this context this study aims at reducing the extent of radiation-induced side effects and toxicity by assuming a better sparing of normal tissue with the use of intensity-modulated instead of conventionally delivered external beam radiotherapy. Methods/design: In this prospective, randomized, single-center trial for patients with spinal bone metastases, RT is performed as either image-guided intensity-modulated radiotherapy (10x3Gy) or conventionally fractionated external beam radiotherapy (10x3Gy). Afterwards radiation-induced toxicity will be assessed and compared 3 and 6 months after the end of radiation. Discussion: The aim of this pilot study is the evaluation of achievable benefits, with reduced radiation toxicity being the primary endpoint in the comparison of intensity-modulated radiotherapy versus conventional radiotherapy for patients with spinal bone metastases. Secondarily, bone re-calcification, quality of life, pain relief, spinal instability, and local control will be measured and compared between the two treatment groups. Trial registration: ClinicalTrials.gov, NCT02832830. Registered on 12 July 2016.
date: 2017
volume: 18
issue: 98
is part of: Trials
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: https://archiv.ub.uni-heidelberg.de/volltextserver/id/document/196658
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subject: 610 Medizin

https://archiv.ub.uni-heidelberg.de/volltextserver/id/document/196658
type: Document
label: Radiation-induced toxicity after image-guided and intensity-modulated radiotherapy versus external beam radiotherapy for patients with spinal bone metastases (IRON-1): a study protocol for a randomized controlled pilot trial (PDF)
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BioMed Central
type: Organization

Trials
type: Collection
issn: 14686694

Thomas Bruckner
type: Person
given name: Thomas
family name: Bruckner

Nils H. Nicolay
type: Person
given name: Nils H.
family name: Nicolay

Ingmar Schlampp
type: Person
given name: Ingmar
family name: Schlampp

Robert Förster
type: Person
given name: Robert
family name: Förster

Eva Meyerhof
type: Person
given name: Eva
family name: Meyerhof

Stefan Ezechiel Welte
type: Person
given name: Stefan Ezechiel
family name: Welte

Jürgen Debus
type: Person
given name: Jürgen
family name: Debus

Harald Rief
type: Person
given name: Harald
family name: Rief

Tilman Bostel
type: Person
given name: Tilman
family name: Bostel

Tanja Sprave
type: Person
given name: Tanja
family name: Sprave

https://archiv.ub.uni-heidelberg.de/volltextserver/id/document/196660
type: Document
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label: Radiation-induced toxicity after image-guided and intensity-modulated radiotherapy versus external beam radiotherapy for patients with spinal bone metastases (IRON-1): a study protocol for a randomized controlled pilot trial (Other)
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https://archiv.ub.uni-heidelberg.de/volltextserver/22707/
title: HTML Summary of #22707 Radiation-induced toxicity after image-guided and intensity-modulated radiotherapy versus external beam radiotherapy for patients with spinal bone metastases (IRON-1): a study protocol for a randomized controlled pilot trial
format: text/html
primary topic: https://archiv.ub.uni-heidelberg.de/volltextserver/id/eprint/22707

610 Medizin
type: Concept
preferred label: 610 Medical sciences Medicine @en