title: Development and implementation of 3D-dosimetric end-to-end tests in adaptive radiation therapy of moving tumors
creator: Mann, Philipp
subject: ddc-530
subject: 530 Physics
subject: ddc-600
subject: 600 Technology (Applied sciences)
description: Clinical implementation of novel advanced treatment techniques in adaptive radiation therapy requires proper workflow verification. However, this subject is not satisfactorily solved yet as current experimental validation techniques do not reflect the complexity of real patient treatments. In this thesis, several methods for patient-specific end-to-end tests were developed and applied to clinical workflows especially including treatments of moving tumors. End-to-end-tests were performed with geometrically well-defined phantoms as well as with an anthropomorphic dynamic ex-vivo porcine lung phantom in combination with a 3-dimensional (3D) polymer gel dosimeter (PGD). Different experimental settings of increasing complexity were tested in terms of (i) accuracy, (ii) feasibility of clinical workflows testing, (iii) validation of clinical concepts for motion-compensated treatments, (iv) additional integration of real-time markerless fluoroscopic imaging, and (v) validation of 4D dose calculation algorithms. Phantom irradiations were performed under static and dynamic conditions with and without beam gating. PGD evaluation revealed good tumor coverage for all treatment concepts and beam gating significantly reduced normal tissue exposure. In all cases, good agreement with the calculated dose distribution was obtained. As a conclusion, the established experimental workflow provides a versatile and valuable tool for geometrical and dosimetrical validation of advanced motion-compensated treatment techniques in adaptive radiation therapy.
date: 2017
type: Dissertation
type: info:eu-repo/semantics/doctoralThesis
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/22913/1/MannPhilipp_PhDThesis.pdf
identifier: DOI:10.11588/heidok.00022913
identifier: urn:nbn:de:bsz:16-heidok-229133
identifier:   Mann, Philipp  (2017) Development and implementation of 3D-dosimetric end-to-end tests in adaptive radiation therapy of moving tumors.  [Dissertation]     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/22913/
rights: info:eu-repo/semantics/openAccess
rights: http://archiv.ub.uni-heidelberg.de/volltextserver/help/license_urhg.html
language: eng