<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Time-cumulated blood pressure exposure and incident impairment of glucose tolerance and diabetes mellitus"^^ . "Background: With the marked increase in the prevalence of diabetes mellitus, it was the purpose of our study to assess a potential association of time-cumulated exposure to systolic (CumSBP) and of diastolic blood pressure (CumDBP) with onset of impaired glucose tolerance and diabetes mellitus. Methods: The prospective investigation included participants of the longitudinal Kailuan Study with three baseline examinations in 2006–2007, 2008–2009 and 2010–2011, re-examination in 2012–2013, and no diabetes mellitus at baseline. Cumulative blood pressure (BP) was calculated as cumBP = [(BP1 + BP2)/2 × time1–2] + [(BP2 + BP3)/2 × time2–3]. Based on cumSBP, the study population was stratified into four groups (cumSBP < 480mmHgxyear;n = 15,339; 480mmHgxyear ≤ cumSBP < 520mmHgxyear;n = 7214; 520mmHgxyears ≤ cumSBP < 560mmHgxyears;n = 5675; and cumSBP ≥ 560mmHgxyears;n = 10,576). Results: After adjusting for demographic, anthropomorphic, biochemical, socioeconomic and lifestyle parameters and as compared with the first group, the second, third and fourth group showed a significantly higher incidence of diabetes (P-trend < 0.001;hazard ratio (HR);95% confidence interval (CI):1.28(1.08,1.51),1.54(1.29,1.84), and 2.33(1.98,2.73), respectively), higher incidence of impairment of glucose tolerance (P-trend < 0.001;HR;95% CI1.17(1.02,1.33), 1.43(1.25,1.64), and 2.09(1.85,2.37), respectively), and higher incidence of diabetes developing out of an impairment of glucose tolerance (P-trend < 0.001;HR;95% CI:1.22(0.97,1.54),1.47(1.16,1.86), and 2.01(1.62,2.50), respectively). An increase in cumSBP by 10 mmHg/year or an increase in cumDBP by 5 mmHg/year was associated with a hazard ratio of incident diabetes of 1.04 (95% CI:1.03,1.04) and 1.02(1.02,1.03), respectively, with a hazard ratio of incident impairment of glucose tolerance of 1.04(95% CI:1.03,1.04) and 1.03(95% CI:1.02,1.03), respectively, and with a hazard ratio of incident diabetes developing from impairment of glucose tolerance of 1.04(95% CI:1.03,1.04) and 1.03(95% CI:1.02,1.03), respectively. Conclusions: Time-cumulated exposure to elevated blood pressure was significantly associated with an elevated incidence of impaired glucose tolerance and diabetes."^^ . "2017" . . "17" . "106" . . "BioMed Central"^^ . . . "BMC Cardiovascular Disorders"^^ . . . "14712261" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Wen Y."^^ . "Gao"^^ . "Wen Y. Gao"^^ . . "Jost B."^^ . "Jonas"^^ . "Jost B. Jonas"^^ . . "Chun Y."^^ . "Ruan"^^ . "Chun Y. Ruan"^^ . . "Xiao M."^^ . "Zheng"^^ . "Xiao M. Zheng"^^ . . "Shuo H."^^ . "Chen"^^ . "Shuo H. Chen"^^ . . "Xiao X."^^ . "Liu"^^ . "Xiao X. Liu"^^ . . "Yun T."^^ . "Wu"^^ . "Yun T. Wu"^^ . . "Lu"^^ . "Song"^^ . "Lu Song"^^ . . "Hai Y."^^ . "Zhao"^^ . "Hai Y. Zhao"^^ . . "Shou L."^^ . "Wu"^^ . "Shou L. Wu"^^ . . "Jing S."^^ . "Gao"^^ . "Jing S. Gao"^^ . . . . . . "Time-cumulated blood pressure exposure and incident impairment of glucose tolerance and diabetes mellitus (PDF)"^^ . . . "12872_2017_Article_537.pdf"^^ . . . "Time-cumulated blood pressure exposure and incident impairment of glucose tolerance and diabetes mellitus (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Time-cumulated blood pressure exposure and incident impairment of glucose tolerance and diabetes mellitus (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Time-cumulated blood pressure exposure and incident impairment of glucose tolerance and diabetes mellitus (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Time-cumulated blood pressure exposure and incident impairment of glucose tolerance and diabetes mellitus (Other)"^^ . . . . . . "small.jpg"^^ . . . "Time-cumulated blood pressure exposure and incident impairment of glucose tolerance and diabetes mellitus (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #22915 \n\nTime-cumulated blood pressure exposure and incident impairment of glucose tolerance and diabetes mellitus\n\n" . "text/html" . . . "610 Medizin"@de . "610 Medical sciences Medicine"@en . .