eprintid: 22915
rev_number: 11
eprint_status: archive
userid: 1589
dir: disk0/00/02/29/15
datestamp: 2017-05-09 08:54:59
lastmod: 2024-03-12 04:11:03
status_changed: 2017-05-09 08:54:59
type: article
metadata_visibility: show
creators_name: Wu, Yun T.
creators_name: Song, Lu
creators_name: Liu, Xiao X.
creators_name: Gao, Jing S.
creators_name: Zheng, Xiao M.
creators_name: Ruan, Chun Y.
creators_name: Zhao, Hai Y.
creators_name: Chen, Shuo H.
creators_name: Gao, Wen Y.
creators_name: Jonas, Jost B.
creators_name: Wu, Shou L.
title: Time-cumulated blood pressure exposure and incident impairment of glucose tolerance and diabetes mellitus
subjects: 610
divisions: 61100
abstract: Background: With the marked increase in the prevalence of diabetes mellitus, it was the purpose of our study to assess a potential association of time-cumulated exposure to systolic (CumSBP) and of diastolic blood pressure (CumDBP) with onset of impaired glucose tolerance and diabetes mellitus.   Methods: The prospective investigation included participants of the longitudinal Kailuan Study with three baseline examinations in 2006–2007, 2008–2009 and 2010–2011, re-examination in 2012–2013, and no diabetes mellitus at baseline. Cumulative blood pressure (BP) was calculated as cumBP = [(BP1 + BP2)/2 × time1–2] + [(BP2 + BP3)/2 × time2–3]. Based on cumSBP, the study population was stratified into four groups (cumSBP < 480mmHgxyear;n = 15,339; 480mmHgxyear ≤ cumSBP < 520mmHgxyear;n = 7214; 520mmHgxyears ≤ cumSBP < 560mmHgxyears;n = 5675; and cumSBP ≥ 560mmHgxyears;n = 10,576).   Results: After adjusting for demographic, anthropomorphic, biochemical, socioeconomic and lifestyle parameters and as compared with the first group, the second, third and fourth group showed a significantly higher incidence of diabetes (P-trend < 0.001;hazard ratio (HR);95% confidence interval (CI):1.28(1.08,1.51),1.54(1.29,1.84), and 2.33(1.98,2.73), respectively), higher incidence of impairment of glucose tolerance (P-trend < 0.001;HR;95% CI1.17(1.02,1.33), 1.43(1.25,1.64), and 2.09(1.85,2.37), respectively), and higher incidence of diabetes developing out of an impairment of glucose tolerance (P-trend < 0.001;HR;95% CI:1.22(0.97,1.54),1.47(1.16,1.86), and 2.01(1.62,2.50), respectively). An increase in cumSBP by 10 mmHg/year or an increase in cumDBP by 5 mmHg/year was associated with a hazard ratio of incident diabetes of 1.04 (95% CI:1.03,1.04) and 1.02(1.02,1.03), respectively, with a hazard ratio of incident impairment of glucose tolerance of 1.04(95% CI:1.03,1.04) and 1.03(95% CI:1.02,1.03), respectively, and with a hazard ratio of incident diabetes developing from impairment of glucose tolerance of 1.04(95% CI:1.03,1.04) and 1.03(95% CI:1.02,1.03), respectively.   Conclusions: Time-cumulated exposure to elevated blood pressure was significantly associated with an elevated incidence of impaired glucose tolerance and diabetes.
date: 2017
publisher: BioMed Central
id_scheme: DOI
ppn_swb: 1659043190
own_urn: urn:nbn:de:bsz:16-heidok-229153
language: eng
bibsort: WUYUNTTIMECUMULA2017
full_text_status: public
publication: BMC Cardiovascular Disorders
volume: 17
number: 106
place_of_pub: London
pagerange: 1-10
issn: 1471-2261
citation:   Wu, Yun T. ; Song, Lu ; Liu, Xiao X. ; Gao, Jing S. ; Zheng, Xiao M. ; Ruan, Chun Y. ; Zhao, Hai Y. ; Chen, Shuo H. ; Gao, Wen Y. ; Jonas, Jost B. ; Wu, Shou L.  (2017) Time-cumulated blood pressure exposure and incident impairment of glucose tolerance and diabetes mellitus.  BMC Cardiovascular Disorders, 17 (106).  pp. 1-10.  ISSN 1471-2261     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/22915/1/12872_2017_Article_537.pdf