title: Pregnancy rates of day 4 and day 5 embryos after culture in an integrated time-lapse incubator
creator: Holschbach, Verena
creator: Weigert, Julia
creator: Dietrich, Jens Erik
creator: Rösner, Sabine
creator: Montag, Markus
creator: Strowitzki, Thomas
creator: Toth, Bettina
subject: ddc-610
subject: 610 Medical sciences Medicine
description: Background: The aim of this study was to compare pregnancy rates in patients undergoing IVF/ICSI with embryo transfer after 4 and 5 days of culture in a closed incubation system with integrated time-lapse imaging.   Methods: Out of n = 2207 in vitro fertilization (IVF)/ intracytoplasmic sperm injection (ICSI) cycles performed between January 2011 and April 2016 at a tertiary referral university hospital, a total of n = 599 IVF/ICSI cycles with prolonged embryo culture in an integrated time-lapse system (EmbryoScope© (Vitrolife)) until day 4 or 5 were retrospectively analyzed with regard to embryo morphology and pregnancy rates.   Results: A transfer on day 5 compared to a transfer on day 4 did not result in higher implantation and clinical pregnancy rates (IR 29.4% on day 4 versus 33.0% on day 5, p = 0.310; CPR 45.2% on day 4 versus 45.7% on day 5, p = 1.0). The percentage of ideal embryos transferred on day 4 was comparable to the rate of ideal embryos transferred on day 5 (41.6% versus 44.1%, p = 0.508). However, on day 4 a significantly higher number of embryos was transferred (1.92 on day 4 versus 1.84 on day 5, p = 0.023), which did not result in higher rates of multiple pregnancies.   Conclusions: Pregnancy rates in IVF/ICSI cycles with integrated time-lapse incubation and transfer on day 4 and 5 are comparable. This finding provides the clinician, IVF laboratory and patient with more flexibility.   Trial registration: This study was retrospectively registered by the local ethics committee of the University of Heidelberg on December 19, 2016 (registration number S-649/2016).
publisher: BioMed Central
date: 2017
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/22936/1/12958_2017_Article_253.pdf
identifier: DOI:
identifier: urn:nbn:de:bsz:16-heidok-229365
identifier:   Holschbach, Verena ; Weigert, Julia ; Dietrich, Jens Erik ; Rösner, Sabine ; Montag, Markus ; Strowitzki, Thomas ; Toth, Bettina  (2017) Pregnancy rates of day 4 and day 5 embryos after culture in an integrated time-lapse incubator.  Reproductive Biology and Endocrinology, 15 (37).  pp. 1-8.  ISSN 1477-7827     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/22936/
rights: info:eu-repo/semantics/openAccess
rights: Please see front page of the work (Sorry, Dublin Core plugin does not recognise license id)
language: eng