<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Pregnancy rates of day 4 and day 5 embryos after culture in an integrated time-lapse incubator"^^ . "Background: The aim of this study was to compare pregnancy rates in patients undergoing IVF/ICSI with embryo transfer after 4 and 5 days of culture in a closed incubation system with integrated time-lapse imaging. Methods: Out of n = 2207 in vitro fertilization (IVF)/ intracytoplasmic sperm injection (ICSI) cycles performed between January 2011 and April 2016 at a tertiary referral university hospital, a total of n = 599 IVF/ICSI cycles with prolonged embryo culture in an integrated time-lapse system (EmbryoScope© (Vitrolife)) until day 4 or 5 were retrospectively analyzed with regard to embryo morphology and pregnancy rates. Results: A transfer on day 5 compared to a transfer on day 4 did not result in higher implantation and clinical pregnancy rates (IR 29.4% on day 4 versus 33.0% on day 5, p = 0.310; CPR 45.2% on day 4 versus 45.7% on day 5, p = 1.0). The percentage of ideal embryos transferred on day 4 was comparable to the rate of ideal embryos transferred on day 5 (41.6% versus 44.1%, p = 0.508). However, on day 4 a significantly higher number of embryos was transferred (1.92 on day 4 versus 1.84 on day 5, p = 0.023), which did not result in higher rates of multiple pregnancies. Conclusions: Pregnancy rates in IVF/ICSI cycles with integrated time-lapse incubation and transfer on day 4 and 5 are comparable. This finding provides the clinician, IVF laboratory and patient with more flexibility. Trial registration: This study was retrospectively registered by the local ethics committee of the University of Heidelberg on December 19, 2016 (registration number S-649/2016)."^^ . "2017" . . "15" . "37" . . "BioMed Central"^^ . . . "Reproductive Biology and Endocrinology"^^ . . . "14777827" . . . . . . . . . . . . . . . . . . . . . . . "Markus"^^ . "Montag"^^ . "Markus Montag"^^ . . "Jens Erik"^^ . "Dietrich"^^ . "Jens Erik Dietrich"^^ . . "Thomas"^^ . "Strowitzki"^^ . "Thomas Strowitzki"^^ . . "Verena"^^ . "Holschbach"^^ . "Verena Holschbach"^^ . . "Sabine"^^ . "Rösner"^^ . "Sabine Rösner"^^ . . "Bettina"^^ . "Toth"^^ . "Bettina Toth"^^ . . "Julia"^^ . "Weigert"^^ . "Julia Weigert"^^ . . . . . . "Pregnancy rates of day 4 and day 5 embryos after culture in an integrated time-lapse incubator (PDF)"^^ . . . "12958_2017_Article_253.pdf"^^ . . . "Pregnancy rates of day 4 and day 5 embryos after culture in an integrated time-lapse incubator (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Pregnancy rates of day 4 and day 5 embryos after culture in an integrated time-lapse incubator (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Pregnancy rates of day 4 and day 5 embryos after culture in an integrated time-lapse incubator (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Pregnancy rates of day 4 and day 5 embryos after culture in an integrated time-lapse incubator (Other)"^^ . . . . . . "small.jpg"^^ . . . "Pregnancy rates of day 4 and day 5 embryos after culture in an integrated time-lapse incubator (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #22936 \n\nPregnancy rates of day 4 and day 5 embryos after culture in an integrated time-lapse incubator\n\n" . "text/html" . . . "610 Medizin"@de . "610 Medical sciences Medicine"@en . .