eprintid: 22936
rev_number: 11
eprint_status: archive
userid: 1589
dir: disk0/00/02/29/36
datestamp: 2017-05-10 08:07:38
lastmod: 2024-03-09 13:53:29
status_changed: 2017-05-10 08:07:38
type: article
metadata_visibility: show
creators_name: Holschbach, Verena
creators_name: Weigert, Julia
creators_name: Dietrich, Jens Erik
creators_name: Rösner, Sabine
creators_name: Montag, Markus
creators_name: Strowitzki, Thomas
creators_name: Toth, Bettina
title: Pregnancy rates of day 4 and day 5 embryos after culture in an integrated time-lapse incubator
subjects: ddc-610
divisions: i-910400
abstract: Background: The aim of this study was to compare pregnancy rates in patients undergoing IVF/ICSI with embryo transfer after 4 and 5 days of culture in a closed incubation system with integrated time-lapse imaging.   Methods: Out of n = 2207 in vitro fertilization (IVF)/ intracytoplasmic sperm injection (ICSI) cycles performed between January 2011 and April 2016 at a tertiary referral university hospital, a total of n = 599 IVF/ICSI cycles with prolonged embryo culture in an integrated time-lapse system (EmbryoScope© (Vitrolife)) until day 4 or 5 were retrospectively analyzed with regard to embryo morphology and pregnancy rates.   Results: A transfer on day 5 compared to a transfer on day 4 did not result in higher implantation and clinical pregnancy rates (IR 29.4% on day 4 versus 33.0% on day 5, p = 0.310; CPR 45.2% on day 4 versus 45.7% on day 5, p = 1.0). The percentage of ideal embryos transferred on day 4 was comparable to the rate of ideal embryos transferred on day 5 (41.6% versus 44.1%, p = 0.508). However, on day 4 a significantly higher number of embryos was transferred (1.92 on day 4 versus 1.84 on day 5, p = 0.023), which did not result in higher rates of multiple pregnancies.   Conclusions: Pregnancy rates in IVF/ICSI cycles with integrated time-lapse incubation and transfer on day 4 and 5 are comparable. This finding provides the clinician, IVF laboratory and patient with more flexibility.   Trial registration: This study was retrospectively registered by the local ethics committee of the University of Heidelberg on December 19, 2016 (registration number S-649/2016).
date: 2017
publisher: BioMed Central
id_scheme: DOI
ppn_swb: 1659043883
own_urn: urn:nbn:de:bsz:16-heidok-229365
language: eng
bibsort: HOLSCHBACHPREGNANCYR2017
full_text_status: public
publication: Reproductive Biology and Endocrinology
volume: 15
number: 37
place_of_pub: London
pagerange: 1-8
issn: 1477-7827
citation:   Holschbach, Verena ; Weigert, Julia ; Dietrich, Jens Erik ; Rösner, Sabine ; Montag, Markus ; Strowitzki, Thomas ; Toth, Bettina  (2017) Pregnancy rates of day 4 and day 5 embryos after culture in an integrated time-lapse incubator.  Reproductive Biology and Endocrinology, 15 (37).  pp. 1-8.  ISSN 1477-7827     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/22936/1/12958_2017_Article_253.pdf