eprintid: 22991
rev_number: 11
eprint_status: archive
userid: 1589
dir: disk0/00/02/29/91
datestamp: 2017-05-29 09:09:56
lastmod: 2024-06-28 04:04:58
status_changed: 2017-05-29 09:09:56
type: article
metadata_visibility: show
creators_name: Luik, Armin
creators_name: Kunzmann, Kevin
creators_name: Hörmann, Patrick
creators_name: Schmidt, Kerstin
creators_name: Radzewitz, Andrea
creators_name: Bramlage, Peter
creators_name: Schenk, Thomas
creators_name: Schymik, Gerhard
creators_name: Merkel, Matthias
creators_name: Kieser, Meinhard
creators_name: Schmitt, Claus
title: Cryoballoon vs. open irrigated radiofrequency ablation for paroxysmal atrial fibrillation: long-term FreezeAF outcomes
subjects: ddc-610
divisions: i-911800
abstract: Background: Effective treatment of paroxysmal atrial fibrillation (AF) is essential for reducing the risk of stroke and heart failure. Cryoballoon (CB) ablation has been developed as an alternative to the use of radiofrequency (RF) energy for electrical isolation of the pulmonary veins. Herein, we provide long-term data regarding the efficacy of CB ablation in comparison to RF.   Methods: FreezeAF was a randomised non-inferiority study comparing CB ablation with RF ablation for the treatment of patients with drug-refractory paroxysmal AF. Procedural success for the long-term follow-up (30 months) was defined as freedom from AF with an absence of persistent complications.   Results: Of the 315 patients that were randomised and received catheter ablation, 292 (92.7%) completed the 30-month follow-up (147 in the RF group and 145 in the CB group). The baseline characteristics of the RF and CB groups were similar. Single-procedure success was achieved by 40% of patients in the RF group and 42% of the CB group (p < 0.001 for non-inferiority). When including re-do procedures in the analysis, the multiple procedure success rate was 72% in the RF group and 76% in the CB group.   Conclusion: The data provide long-term evidence that CB ablation is non-inferior to RF ablation, with high proportions of patients reporting freedom from AF 30 months after the index procedure.   Trial registration: ClinicalTrials.gov Identifier: NCT00774566; first registered October 16, 2008; first patient included October 20, 2008.
date: 2017
publisher: BioMed Central
id_scheme: DOI
ppn_swb: 165920478X
own_urn: urn:nbn:de:bsz:16-heidok-229913
language: eng
bibsort: LUIKARMINCRYOBALLOO2017
full_text_status: public
publication: BMC Cardiovascular Disorders
volume: 17
number: 135
place_of_pub: London
pagerange: 1-8
issn: 1471-2261
citation:   Luik, Armin ; Kunzmann, Kevin ; Hörmann, Patrick ; Schmidt, Kerstin ; Radzewitz, Andrea ; Bramlage, Peter ; Schenk, Thomas ; Schymik, Gerhard ; Merkel, Matthias ; Kieser, Meinhard ; Schmitt, Claus  (2017) Cryoballoon vs. open irrigated radiofrequency ablation for paroxysmal atrial fibrillation: long-term FreezeAF outcomes.  BMC Cardiovascular Disorders, 17 (135).  pp. 1-8.  ISSN 1471-2261     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/22991/1/12872_2017_Article_566.pdf