title: Genetic variants of MICB and PLCE1 and associations with the laboratory features of dengue
creator: Whitehorn, James
creator: Kien, Duong Thi Hue
creator: Quyen, Nguyen Than Ha
creator: Wills, Bridget
creator: Chau, Nguyen Van Vinh
creator: Tam, Dong Thi Hoai
creator: Tuan, Nguyen Minh
creator: Jänisch, Thomas
creator: Hibberd, Martin
creator: Khor, Chiea Chuen
creator: Simmons, Cameron P.
subject: ddc-610
subject: 610 Medical sciences Medicine
description: Background: A previous genome-wide association study identified 2 susceptibility loci for severe dengue at MICB rs3132468 and PLCE1 rs3740360 and further work showed these mutations to be also associated with less severe clinical presentations. The aim of this study was to determine if these specific loci were associated with laboratory features of dengue that correlate with clinical severity with the aim of elucidating the functional basis of these genetic variants.   Methods: This was a case-only analysis of laboratory-confirmed dengue patients obtained from 2 prospective cohort studies and 1 randomised clinical trial in Vietnam (Trial registration: ISRCTN ISRCTN03147572. Registered 24th July 2012). 2742 dengue cases were successfully genotyped at MICB rs3132468 and PLCE1 rs3740360. Laboratory variables were compared between genotypes and stratified by DENV serotype.   Results: The analysis showed no association between MICB and PLCE1 genotype and early viraemia level, platelet nadir, white cell count nadir, or maximum haematocrit in both overall analysis and in analysis stratified by serotype.   Discussion: The lack of an association between genotype and viremia level may reflect the sampling procedures within the included studies. The study findings mean that the functional basis of these mutations remains unclear. Trial registration: ISRCTN ISRCTN03147572. Registered 24th July 2012.
publisher: BioMed Central; Springer
date: 2017
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/23056/1/12879_2017_Article_2514.pdf
identifier: DOI:
identifier: urn:nbn:de:bsz:16-heidok-230566
identifier:   Whitehorn, James ; Kien, Duong Thi Hue ; Quyen, Nguyen Than Ha ; Wills, Bridget ; Chau, Nguyen Van Vinh ; Tam, Dong Thi Hoai ; Tuan, Nguyen Minh ; Jänisch, Thomas ; Hibberd, Martin ; Khor, Chiea Chuen ; Simmons, Cameron P.  (2017) Genetic variants of MICB and PLCE1 and associations with the laboratory features of dengue.  BMC Infectious Diseases, 17 (412).  pp. 1-6.  ISSN 1471-2334     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/23056/
rights: info:eu-repo/semantics/openAccess
rights: Please see front page of the work (Sorry, Dublin Core plugin does not recognise license id)
language: eng