eprintid: 23056
rev_number: 12
eprint_status: archive
userid: 1589
dir: disk0/00/02/30/56
datestamp: 2017-06-13 13:00:48
lastmod: 2024-03-30 13:21:22
status_changed: 2017-06-13 13:00:48
type: article
metadata_visibility: show
creators_name: Whitehorn, James
creators_name: Kien, Duong Thi Hue
creators_name: Quyen, Nguyen Than Ha
creators_name: Wills, Bridget
creators_name: Chau, Nguyen Van Vinh
creators_name: Tam, Dong Thi Hoai
creators_name: Tuan, Nguyen Minh
creators_name: Jänisch, Thomas
creators_name: Hibberd, Martin
creators_name: Khor, Chiea Chuen
creators_name: Simmons, Cameron P.
title: Genetic variants of MICB and PLCE1 and associations with the laboratory features of dengue
subjects: ddc-610
divisions: i-911700
abstract: Background: A previous genome-wide association study identified 2 susceptibility loci for severe dengue at MICB rs3132468 and PLCE1 rs3740360 and further work showed these mutations to be also associated with less severe clinical presentations. The aim of this study was to determine if these specific loci were associated with laboratory features of dengue that correlate with clinical severity with the aim of elucidating the functional basis of these genetic variants.   Methods: This was a case-only analysis of laboratory-confirmed dengue patients obtained from 2 prospective cohort studies and 1 randomised clinical trial in Vietnam (Trial registration: ISRCTN ISRCTN03147572. Registered 24th July 2012). 2742 dengue cases were successfully genotyped at MICB rs3132468 and PLCE1 rs3740360. Laboratory variables were compared between genotypes and stratified by DENV serotype.   Results: The analysis showed no association between MICB and PLCE1 genotype and early viraemia level, platelet nadir, white cell count nadir, or maximum haematocrit in both overall analysis and in analysis stratified by serotype.   Discussion: The lack of an association between genotype and viremia level may reflect the sampling procedures within the included studies. The study findings mean that the functional basis of these mutations remains unclear. Trial registration: ISRCTN ISRCTN03147572. Registered 24th July 2012.
date: 2017
publisher: BioMed Central; Springer
id_scheme: DOI
ppn_swb: 1659252776
own_urn: urn:nbn:de:bsz:16-heidok-230566
language: eng
bibsort: WHITEHORNJGENETICVAR2017
full_text_status: public
publication: BMC Infectious Diseases
volume: 17
number: 412
place_of_pub: London; Berlin; Heidelberg
pagerange: 1-6
issn: 1471-2334
citation:   Whitehorn, James ; Kien, Duong Thi Hue ; Quyen, Nguyen Than Ha ; Wills, Bridget ; Chau, Nguyen Van Vinh ; Tam, Dong Thi Hoai ; Tuan, Nguyen Minh ; Jänisch, Thomas ; Hibberd, Martin ; Khor, Chiea Chuen ; Simmons, Cameron P.  (2017) Genetic variants of MICB and PLCE1 and associations with the laboratory features of dengue.  BMC Infectious Diseases, 17 (412).  pp. 1-6.  ISSN 1471-2334     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/23056/1/12879_2017_Article_2514.pdf