title: Prognosis and longitudinal changes of physical activity in idiopathic pulmonary fibrosis
creator: Bahmer, Thomas
creator: Kirsten, Anne-Marie
creator: Waschki, Benjamin
creator: Rabe, Klaus F.
creator: Magnussen, Helgo
creator: Kirsten, Detlef
creator: Gramm, Marco
creator: Hummler, Simone
creator: Brunnemer, Eva
creator: Kreuter, Michael
creator: Watz, Henrik
subject: 610
subject: 610 Medical sciences Medicine
description: Background: Physical activity (PA) is associated with disease severity in idiopathic pulmonary fibrosis (IPF), but longitudinal studies evaluating its prognostic value and changes over time are lacking.   Methods: We measured PA (steps per day, SPD) in a cohort of 46 IPF-patients (mean age, 67 years; mean FVC, 76.1%pred.) by accelerometry at baseline, recorded survival status during 3 years follow-up and repeated measurements in survivors. We compared the prognostic value of PA to established mortality predictors including lung function (FVC, DLCO) and 6-min walking-distance (6MWD).   Results: During follow-up (median 34 months) 20 patients (43%) died. SPD and FVC best identified non-survivors (AUROC-curve 0.79, p < 0.01). After adjustment for confounders (sex, age, therapy), a standardized increase (i.e. one SD) in SPD, FVC%pred. or DLCO%pred. was associated with a more than halved risk of death (HR < 0.50; p < 0.01). Compared to baseline, SPD, FVC, and 6MWD annually declined in survivors by 973 SPD, 130 ml and 9 m, resulting in relative declines of 48.3% (p < 0.001), 13.3% (p < 0.001) and 7.8% (p = 0.055), respectively.   Conclusion: While PA predicts mortality of IPF patients similar to established functional measures, longitudinal decline of PA seems to be disproportionally large. Our data suggest that the clinical impact of disease progression could be underestimated by established functional measures.
publisher: BioMed Central
date: 2017
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/23282/1/12890_2017_Article_444.pdf
identifier: DOI:
identifier: urn:nbn:de:bsz:16-heidok-232824
identifier:   Bahmer, Thomas ; Kirsten, Anne-Marie ; Waschki, Benjamin ; Rabe, Klaus F. ; Magnussen, Helgo ; Kirsten, Detlef ; Gramm, Marco ; Hummler, Simone ; Brunnemer, Eva ; Kreuter, Michael ; Watz, Henrik  (2017) Prognosis and longitudinal changes of physical activity in idiopathic pulmonary fibrosis.  BMC Pulmonary Medicine, 17 (104).  pp. 1-8.  ISSN 1471-2466     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/23282/
rights: info:eu-repo/semantics/openAccess
rights: Please see front page of the work (Sorry, Dublin Core plugin does not recognise license id)
language: eng