eprintid: 23282
rev_number: 11
eprint_status: archive
userid: 1589
dir: disk0/00/02/32/82
datestamp: 2017-08-03 09:01:54
lastmod: 2017-09-26 15:46:40
status_changed: 2017-08-03 09:01:54
type: article
metadata_visibility: show
creators_name: Bahmer, Thomas
creators_name: Kirsten, Anne-Marie
creators_name: Waschki, Benjamin
creators_name: Rabe, Klaus F.
creators_name: Magnussen, Helgo
creators_name: Kirsten, Detlef
creators_name: Gramm, Marco
creators_name: Hummler, Simone
creators_name: Brunnemer, Eva
creators_name: Kreuter, Michael
creators_name: Watz, Henrik
title: Prognosis and longitudinal changes of physical activity in idiopathic pulmonary fibrosis
subjects: 610
divisions: 942000
abstract: Background: Physical activity (PA) is associated with disease severity in idiopathic pulmonary fibrosis (IPF), but longitudinal studies evaluating its prognostic value and changes over time are lacking.   Methods: We measured PA (steps per day, SPD) in a cohort of 46 IPF-patients (mean age, 67 years; mean FVC, 76.1%pred.) by accelerometry at baseline, recorded survival status during 3 years follow-up and repeated measurements in survivors. We compared the prognostic value of PA to established mortality predictors including lung function (FVC, DLCO) and 6-min walking-distance (6MWD).   Results: During follow-up (median 34 months) 20 patients (43%) died. SPD and FVC best identified non-survivors (AUROC-curve 0.79, p < 0.01). After adjustment for confounders (sex, age, therapy), a standardized increase (i.e. one SD) in SPD, FVC%pred. or DLCO%pred. was associated with a more than halved risk of death (HR < 0.50; p < 0.01). Compared to baseline, SPD, FVC, and 6MWD annually declined in survivors by 973 SPD, 130 ml and 9 m, resulting in relative declines of 48.3% (p < 0.001), 13.3% (p < 0.001) and 7.8% (p = 0.055), respectively.   Conclusion: While PA predicts mortality of IPF patients similar to established functional measures, longitudinal decline of PA seems to be disproportionally large. Our data suggest that the clinical impact of disease progression could be underestimated by established functional measures.
date: 2017
publisher: BioMed Central
id_scheme: DOI
id_number: http://dx.doi.org/10.1186/s12890-017-0444-0
ppn_swb: 1655666479
own_urn: urn:nbn:de:bsz:16-heidok-232824
language: eng
bibsort: BAHMERTHOMPROGNOSISA2017
full_text_status: public
publication: BMC Pulmonary Medicine
volume: 17
number: 104
place_of_pub: London
pagerange: 1-8
issn: 1471-2466
citation:   Bahmer, Thomas ; Kirsten, Anne-Marie ; Waschki, Benjamin ; Rabe, Klaus F. ; Magnussen, Helgo ; Kirsten, Detlef ; Gramm, Marco ; Hummler, Simone ; Brunnemer, Eva ; Kreuter, Michael ; Watz, Henrik  (2017) Prognosis and longitudinal changes of physical activity in idiopathic pulmonary fibrosis.  BMC Pulmonary Medicine, 17 (104).  pp. 1-8.  ISSN 1471-2466     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/23282/1/12890_2017_Article_444.pdf